MAP2K4 antibody

Catalog No. ABIN966514

This Monoclonal antibody specifically detects MAP2K4 in WB, IHC and ELISA. It exhibits reactivity toward Human. It has been mentioned in 2+ publications

Quick Overview for MAP2K4 antibody (ABIN966514)

Target: MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4))

Reactivity: Human

Host: Please inquire

Clonality: Monoclonal

Conjugate: This MAP2K4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-MAP2K4 Antibody

Specificity: Ni-NTA purified truncated recombinant MAP2K4 expressed in E. Coli strain BL21 (DE3)

Purification: Antibodies are purified by protein A affinity chromatography

Isotype: IgM

Application Details

Application Notes: Western Blot: 1: 500- 1: 1,000
IHC(P): 1: 500- 1: 1,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Storage: -20 °C

References for anti-MAP2K4 antibody (ABIN966514)

Kim, Vander Griend, Yang, Benson, Dubauskas, Yoshida, Chekmareva, Ichikawa, Sokoloff, Zhan, Karrison, Lin, Stadler, Ichikawa, Rubin, Rinker-Schaeffer: "Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers." in: Cancer research, Vol. 61, Issue 7, pp. 2833-7, (2001) (PubMed).

Cuenda: "Mitogen-activated protein kinase kinase 4 (MKK4)." in: The international journal of biochemistry & cell biology, Vol. 32, Issue 6, pp. 581-7, (2000) (PubMed).

Target Details for MAP2K4

Target: MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4))

Alternative Name: MAP2K4

Background: MAP2K4(mitogen-activated protein kinase kinase 4), which is located on chromosome 17p11.2, with 399-amino acid protein (about 45 kDa), belongs to the family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. MEK-4 (also called MEK4/MKK4) activates both p38 and JNK MAP kinases. MKK4 is a central mediator in the stress activated protein kinase signaling pathway that responds to a number of cellular and environmental stressors. By phosphorylating MAP kinases such as JNK,MKK4 can ultimately transmit stress signals to nuclear transcription factors that mediate various processes including proliferation, apoptosis, and differentiation. Its distinct biological functions have been identified for MKK4 including a role in development, hepatogenesis, and metastasis suppression.

Gene ID: 6416

Pathways: MAPK Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, BCR Signaling