Bcl-2 antibody

Catalog No. ABIN968975

Product Details anti-Bcl-2 Antibody

Target: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This Bcl-2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Immunogen: Synthetic peptide corresponding to residues surrounding BCL-2, conjugated to KLH.

Clone: 8-00E-12

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

References for anti-Bcl-2 antibody (ABIN968975)

Choi, Feng, Yoon: "FKBP38 protects Bcl-2 from caspase-dependent degradation." in: The Journal of biological chemistry, Vol. 285, Issue 13, pp. 9770-9, (2010) (PubMed).

Munda, Hajdinjak, Kavalar, Stiblar Martincic: "p53, Bcl-2 and AgNOR tissue markers: model approach in predicting prostate cancer characteristics." in: The Journal of international medical research, Vol. 37, Issue 6, pp. 1868-76, (2010) (PubMed).

Murphy, Green, Adams, Squire, Kuo, McKay: "Pharmacogenomics in the curricula of colleges and schools of pharmacy in the United States." in: American journal of pharmaceutical education, Vol. 74, Issue 1, pp. 7, (2010) (PubMed).

Target Details for Bcl-2

Target: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Alternative Name: BCL-2 (BCL2 Products)

Synonyms: Bcl-2 antibody, PPP1R50 antibody, bcl-2 antibody, AW986256 antibody, C430015F12Rik antibody, D630044D05Rik antibody, D830018M01Rik antibody, BCL-2 antibody, Bcl2 antibody, BCL2, apoptosis regulator antibody, B cell leukemia/lymphoma 2 antibody, B-cell CLL/lymphoma 2a antibody, B-cell CLL/lymphoma 2 protein antibody, BCL2 antibody, Bcl2 antibody, bcl2a antibody, BCL-2 antibody

Background:

Description: This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma.Tissue specificity: Expressed in a variety of tissues.

Aliases: Bcl-2, BCL2

Molecular Weight: 26 kDa

Gene ID: 596

HGNC: 596

Pathways: MAPK Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling