PDGFRB antibody

Catalog No. ABIN969346

Product Details anti-PDGFRB Antibody

Target: PDGFRB (Platelet Derived Growth Factor Receptor beta (PDGFRB))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This PDGFRB antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: purified

Immunogen: Purified recombinant fragment of human PDGFRbeta expressed in E. coli.

Clone: 1A2

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

References for anti-PDGFRB antibody (ABIN969346)

Gredmark, Strååt, Homman-Loudiyi, Kannisto, Söderberg-Nauclér: "Human cytomegalovirus downregulates expression of receptors for platelet-derived growth factor by smooth muscle cells." in: Journal of virology, Vol. 81, Issue 10, pp. 5112-20, (2007) (PubMed).

Wilczynski, Chen, Chen, Howell, Shively, Alberts: "Expression and mutational analysis of tyrosine kinase receptors c-kit, PDGFRalpha, and PDGFRbeta in ovarian cancers." in: Human pathology, Vol. 36, Issue 3, pp. 242-9, (2005) (PubMed).

Hansen, Rönnstrand, Rorsman, Hellman, Heldin: "Association of coatomer proteins with the beta-receptor for platelet-derived growth factor." in: Biochemical and biophysical research communications, Vol. 235, Issue 3, pp. 455-60, (1997) (PubMed).

Target Details for PDGFRB

Target: PDGFRB (Platelet Derived Growth Factor Receptor beta (PDGFRB))

Alternative Name: PDGFRbeta (PDGFRB Products)

Synonyms: AI528809 antibody, CD140b antibody, PDGFR-1 antibody, Pdgfr antibody, CD140B antibody, IBGC4 antibody, JTK12 antibody, PDGFR antibody, PDGFR1 antibody, platelet derived growth factor receptor, beta polypeptide antibody, platelet derived growth factor receptor beta antibody, Pdgfrb antibody, PDGFRB antibody

Background:

Description: Platelet-derived growth factor receptor, beta polypeptide, also known as PDGFRB, PDGFRβ or CD140B. It is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. This family exist as several disulphide-bonded, dimeric isoforms (PDGF AA, PDGF AB, PDGF BB, PDGF CC and PDGF DD) that bind in a specific pattern to two closely related receptor tyrosine kinases, PDGF receptor α (PDGFRα) and PDGF receptor β (PDGFRβ). These growth factors are mitogens for cells of mesenchymal origin. PDGFRB is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor, all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

Aliases: JTK12, PDGFR, CD140B, PDGFR1, PDGFRB

Molecular Weight: 190 kDa

Gene ID: 5159

HGNC: 5159

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling