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anti-Human Lamin B1 Antibodies:
anti-Mouse (Murine) Lamin B1 Antibodies:
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Human Polyclonal Lamin B1 Primary Antibody for ICC, IHC (fro) - ABIN3043687
Zhu, Liu, Li, Liu, Wang, Sun, Xiong, Jiang, Zheng, Hu: Protein tyrosine phosphatase receptor U (PTPRU) is required for glioma growth and motility. in Carcinogenesis 2014
Show all 18 Pubmed References
Human Polyclonal Lamin B1 Primary Antibody for IHC (p), WB - ABIN3042505
Liu, Ma, Wu, Li, Zhang, Han, Wang, Reindl, Wu, Ma: Arginine deiminase augments the chemosensitivity of argininosuccinate synthetase-deficient pancreatic cancer cells to gemcitabine via inhibition of NF-?B signaling. in BMC cancer 2014
Show all 15 Pubmed References
Cow (Bovine) Monoclonal Lamin B1 Primary Antibody for DB, ELISA - ABIN108542
Weaver, Carson, Walker, Chaly, Lach, Raymond, Brown, Sikorska: Degradation of nuclear matrix and DNA cleavage in apoptotic thymocytes. in Journal of cell science 1996
Show all 12 Pubmed References
Human Monoclonal Lamin B1 Primary Antibody for ICC, FACS - ABIN335391
Broers, Bronnenberg, Kuijpers, Schutte, Hutchison, Ramaekers: Partial cleavage of A-type lamins concurs with their total disintegration from the nuclear lamina during apoptosis. in European journal of cell biology 2003
Show all 9 Pubmed References
Human Polyclonal Lamin B1 Primary Antibody for WB - ABIN2668811
Yang, Fan, Camp, van Buren, Liu, Somcio, Gray, Cheng, Hoff, Ellis: Chronic oxaliplatin resistance induces epithelial-to-mesenchymal transition in colorectal cancer cell lines. in Clinical cancer research : an official journal of the American Association for Cancer Research 2006
Show all 3 Pubmed References
Human Polyclonal Lamin B1 Primary Antibody for WB - ABIN537491
Koenig, Mueller, Hasel, Adler, Menke: Collagen type I induces disruption of E-cadherin-mediated cell-cell contacts and promotes proliferation of pancreatic carcinoma cells. in Cancer research 2006
Polyclonal Lamin B1 Primary Antibody for IHC (fro), IF - ABIN540564
Pollard, Chan, Grant, Sullivan, Tan, Glass: In vitro posttranslational modification of lamin B cloned from a human T-cell line. in Molecular and cellular biology 1990
Show all 2 Pubmed References
Cow (Bovine) Polyclonal Lamin B1 Primary Antibody for WB - ABIN2782509
Lee, Seng, Sekine, Hinton, Fu, Avraham, Avraham: Vascular endothelial growth factor mediates intracrine survival in human breast carcinoma cells through internally expressed VEGFR1/FLT1. in PLoS medicine 2007
Lamin B counteracts the kinesin Eg5 (show KIF11 Antibodies) to restrain spindle pole separation during spindle assembly.
down-regulation of Lamin B1 and up-regulation of Nephroblastoma overexpressed (NOV (show NOV Antibodies)) are at least partially responsible for the inhibitory effect of Huaier on the proliferative and invasive capacity of SKHEP-1 cells
The aim of the present study was to elucidate the influence of LMNB1 upregulation on colon cancer cell line after treatment with 5-FU. The results indicate, that overexpression of LMNB1 induced dose-dependent cell death mainly by mitotic catastrophe pathway.
In this report we show that increased self-association propensity of mutant LA modulates the LA-LB1 (show CKAP2 Antibodies) interaction and precludes the formation of an otherwise uniform laminar network. Our results might highlight the role of homotypic and heterotypic interactions of LA in the pathogenesis of DCM and hence laminopathies in the broader sense.
These results suggest that the nuclear lamins and progerin have marginal roles in the activation of the antioxidant Nrf2 (show GABPA Antibodies) response to arsenic and cadmium.
We show that epithelial cells failing to undergo proliferation arrest during TGF-beta (show TGFB1 Antibodies)-induced EMT (show ITK Antibodies) sustain mitotic abnormalities due to failed cytokinesis, resulting in aneuploidy. This genomic instability is associated with the suppression of multiple nuclear envelope proteins implicated in mitotic regulation and is phenocopied by modulating the expression of LaminB1.
The primary response of cells to various stresses leading to senescence consists of the down-regulation of LBR (show LBR Antibodies) and LB1 (show CKAP2 Antibodies) to attain reversal of the chromatin architecture.
Data show that lamins A and B are differently processed in staurosporine and beta-Amyloid peptide (show APP Antibodies) fragments Abeta42-treated cells.
The tail domain of lamin B1 is more strongly modulated by divalent cations than lamin A (show LMNA Antibodies).
An upstream mutation alters LMNB1 gene expression in autosomal dominant adult-onset demyelinating leukodystrophy.
Deregulation of LMNB1 expression induces modified splicing of several genes, likely driven by raver-2 (show RAVER2 Antibodies) overexpression, and suggest that an alteration of mRNA processing could be a pathogenic mechanism in adult-onset autosomal dominant leukodystrophy.
The parts of chromatin interact with nuclear lamina proteins like Lamin B1 and, therefore, can be identified in a given cell type by chromatin profiling of these proteins.
While the distribution patterns of both lamins closely paralleled the respective stages of mitosis, Nup160 (show NUP160 Antibodies) localization in metaphase oocytes corresponded to that in mitotic prometaphase rather than metaphase.
Here we report that in primary mouse cortical neurons, LMNB1 overexpression reduces axonal outgrowth, whereas deficiency of endogenous Lmnb1 results in aberrant dendritic development.
Analysis of lamin B1 expression in different regions of the brain in wild-type animals showed that the level of Lmnb1 transcript decreased significantly in an age-dependent manner.
Lamin-B1 is required for organization of lamin-A/C (show LMNA Antibodies) and lamin-B2 (show LMNB2 Antibodies) in mouse embryonic stem cells and Lamin-B1 is required for organization of lamin-A/C (show LMNA Antibodies) and lamin-B2 (show LMNB2 Antibodies) in differentiated cells
farnesylation of lamin B1--but not lamin B2 (show LMNB2 Antibodies)--is crucial for brain development and for retaining chromatin within the bounds of the nuclear lamina during neuronal migration.
lamin B1 overexpression mediates oligodendrocyte cell-autonomous neuropathology in adult-onset autosomal-dominant leukodystrophy.
We conclude that lamin B1 is a modifier gene of major effect for Neural tube defects resulting from loss of Grhl3 (show GRHL3 Antibodies) function
Lamin B1 is lost from primary human and murine cell strains when they are induced to senesce.
Lamin B1 is essential for brain development and is required for the integrity of the nuclear lamina.
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD).