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|Antigen||Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This BRE antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-BRE AntibodyTarget Details BRE Application Details Handling Images
|Specificity||This antibody reacts to Brain And Reproductive Organ-expressed Protein (BRE).|
Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human.
|Plasmids, Primers & others|
Target Details BREProduct Details anti-BRE Antibody Application Details Handling Images back to top
|Alternative Name||BRE / BRCC45 (BRE Antibody Abstract)|
|Background||BRCC45 was initially suggested to be a housekeeping protein that is highly expressed in brain and reproductive organs. Later experiments indicated BRCC45 forms a complex with the breast and ovarian predisposition proteins BRCA1 and BRCA2 as well as RAD51 and BRCC36. This complex has a ubiquitin E3 ligase activity and is thought to enhance cellular survival following DNA damage. BRCC45 has also been suggested to function as a death receptor associated anti apoptotic protein by inhibiting the BID induced activation of the mitochondrial apoptotic pathway. Higher levels of BRCC45 were detected in the majority of hepatocellular carcinomas, suggesting that BRCC45 may promote tumorigenesis when overexpressed. At least three isoforms of BRCC45 are known to exist.Synonyms: BRCA1-A complex subunit BRE, BRCA1/BRCA2-containing complex subunit 45, BRCC45, BRE, Brain and reproductive organ-expressed protein|
|Pathways||Positive Regulation of Response to DNA Damage Stimulus|
Application DetailsProduct Details anti-BRE Antibody Target Details BRE Handling Images back to top
Immunohistochemistry on paraffin sections: 5 μg/mL. Western blot: 1 - 2 μg/mL. ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-BRE Antibody Target Details BRE Application Details Images back to top
|Buffer||PBS containing 0.02 % sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
ImagesProduct Details anti-BRE Antibody Target Details BRE Application Details Handling back to top