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Ca(v)2.3 Ca2 (show CA2 Proteins)+ channel interacts with the G1-subunit of V-ATPase (show ATP6V1H Proteins).
This study identified a polymorphism in exon 20 of the CACNA1E gene (Asp859Glu - rs35737760) that is more prevalent in hemiplegic and brain stem aura (show AURKA Proteins) migraine.
Data suggest that, in vascular smooth muscle cells, increase in cytosolic endothelin-1 (EDN1 (show EDN1 Proteins)) induces sustained increase in nuclear Ca2 (show CA2 Proteins)+ via stimulation of R-type calcium channel (CACNA1E) present at the nuclear membrane.
CACNA1E gene single nucleotide polymorphisms may be involved in fentanyl sensitivity.
The C-terminus of human Ca(v)2.3 voltage-gated calcium channel interacts with alternatively spliced calmodulin-2 expressed in two human cell lines
quartet of leucine residues in the guanylate kinase (show GUK1 Proteins) domain of CaVbeta determines the plasma membrane density of the CaV2.3 channel.
CACNA1E variants affect beta cell function in patients with newly diagnosed type 2 diabetes.
the II-III loop of the Ca(v)2.3 calcium channel binds APLP1 (show APLP1 Proteins) and that this binding promotes internalization of the channel
Lack of high-voltage activated Cav2.3 channels results in a marked decrease in the sensitivity of transgenic animals to gamma-butyrolactone-induced absence epilepsy.
Swapping the I-II intracellular linker between L-type CaV1.2 (show CACNA1C Proteins) and R-type CaV2.3 high-voltage gated calcium channels exchanges activation attributes.
The results of this study showed that Cav2.3 is a novel mechanistic target for a key pronociceptive miRNA, miR (show MLXIP Proteins)-34c-5p.
Data show that apamin boosts evoked excitatory postsynaptic potentials (EPSPs) in CaV2.3 R-Type Ca2 (show CA2 Proteins)+ Channel knockout (CaV2.3-/-) mice.
under conditions of Zn2+ deficiency, ablation or dysfunction of Cav2.3 channels may lead to severe disturbances in glucose homeostasis.
Cav2.1 (show CACNA1A Proteins)-2.3 have unique contributions to the dynamics at the Schaffer collateral synapse that are engaged by the complex patterns of afferent activity seen in vivo
Low-voltage activated CaV2.3 R-type Ca(2 (show CA2 Proteins)+) channels in the thalamocortical loop and extra-thalamocortical circuitries substantially regulate rodent sleep architecture and represent a novel potential target for pharmacological treatment of sleep disorders
Cacna1e expression (and Cacna1h (show CACNA1H Proteins)) is essential for paraventricular hypothalamic neuronal activity and preventing hyperphagia.
Cav2.3 does not only contribute to the cardiac autonomous nervous system but also to intrinsic rhythm propagation.
Cav2.3 voltage-gated divalent calcium channels (VGCC) are an important factor in septohippocampal synchronization associated with theta; oscillation.
stimulation with exogenous PACAP (show ADCYAP1 Proteins) and native neuronal stress stimulation both lead to a PKC-mediated phosphodependent recruitment of a T-type Ca(v)3.2 Ca(2 (show CA2 Proteins)+) influx, which in turn evokes catecholamine release during the acute sympathetic stress response
Both high-affinity Ni(2 (show VMP1 Proteins)+)-sensitive Ca(2 (show CA2 Proteins)+) channels contribute to transretinal signalling.
Inhibition of CaV2.3 channels by NK1 (show B3GAT1 Proteins) receptors is sensitive to membrane cholesterol but insensitive to caveolin-1 (show CAV1 Proteins).
Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels, which belong to the 'high-voltage activated' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
voltage-dependent R-type calcium channel subunit alpha-1E
, voltage-gated calcium channel alpha 1E subunit
, calcium channel, voltage-dependent, R type, alpha 1E subunit
, brain calcium channel II
, calcium channel, L type, alpha-1 polypeptide
, calcium channel, R type, alpha-1 polypeptide
, calcium channel, voltage-dependent, alpha 1E subunit
, voltage-dependent calcium channel alpha 1E subunit
, voltage-gated calcium channel alpha subunit Cav2.3
, voltage-gated calcium channel subunit alpha Cav2.3
, calcium channel, voltage-dependent, L type, alpha 1E subunit
, voltage gated calcium channel alpha1E subunit
, voltage-dependent calcium channel alpha1-E subunit
, brain calcium channel BII-1
, brain calcium channel BII-2