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Neuronal pentraxin 1 accumulates on the postsynaptic terminal forming functional synapses.
work highlights a potential role for synaptic proteins, such as NP1 and glutamate (show GRIN1 Antibodies) receptors in lysosomal storage diseases.
Results demonstrate a novel mechanism of neuronal death and predict that inhibition of NP1 expression is a promising strategy to prevent hypoxic-ischemic injury in immature brain
results demonstrate that extracellular release of NP1 promote hypoxic-ischemic neuronal death possibly via surface clustering with GluR1 (show GRIA1 Antibodies) at synaptic sites and that NP1, not its family member NP2 (show NRP2 Antibodies), is involved in the neuronal death mechanisms
Genetic deletion of NP1 prevents hypoxic-ischemic neuronal death by reducing synaptic clustering of GluR1 (show GRIA1 Antibodies).
These findings suggest that Narp (show NPTX2 Antibodies) in the mPFC mediates the extinction of morphine conditioned place preference.
our findings demonstrate a novel mechanism by which NP1 regulates mitochondria-driven hippocampal cell death
NP1 facilitates the accumulation of BCL2-associated X protein (BAX (show BAX Antibodies)) in mitochondria and regulates mitochondrial dynamics during apoptosis in mouse cerebellar granule neurons in culture.
Neuronal pentraxin 1 induction in hypoxic-ischemic neuronal death is regulated via a glycogen synthase kinase-3alpha/beta dependent mechanism
data indicate that the loss of NP1/2 disrupts several aspects of retinogeniculate development including the initial establishment of AMPAR transmission and the subsequent elimination of inappropriate circuit connections
Results show that Nrp1 (show NELL1 Antibodies) plays a critical role in balancing responsiveness to VEGF-A (show VEGFA Antibodies) versus TGFbeta (show TGFB1 Antibodies) to regulate glioblastoma growth, progression, and recurrence after anti-vascular therapy.
Data provide evidence that NRP1 (show NELL1 Antibodies) functions to enhance the metastatic potential of prostate tumors.
NRP1 (show NELL1 Antibodies) is an important niche component
our data suggest a novel molecular mechanism by which tMUC1 may modulate NRP1 (show NELL1 Antibodies)-dependent VEGFR (show KDR Antibodies) signaling in PDA cells.
Our findings identify aberrant active integrin b1-driven Src (show SRC Antibodies)-Akt (show AKT1 Antibodies) hyperactivation as a primary resistance mechanism to cetuximab in PDAC cells and offer an effective therapeutic strategy to overcome this resistance using an EGFR (show EGFR Antibodies) and NRP1 (show NELL1 Antibodies) dual targeting antibody
VEGF-A (show VEGFA Antibodies) acts via interaction with NRP-1 (show NELL1 Antibodies) to trigger intracellular events leading to ECS cell survival and formation of aggressive, invasive and highly vascularized tumors.
These data identify a new molecular mechanism of brain microvascular endothelial inflammatory response through NRP1 (show NELL1 Antibodies)-IFNgamma crosstalk.
This study indicates that capsaicin application results in significant loss of epidermal NRP-1 (show NELL1 Antibodies) receptor expression, whereas diabetic subjects presenting small fiber neuropathy show full epidermal NRP-1 (show NELL1 Antibodies) expression in contrast to the basal expression pattern seen in healthy controls
Study show that a high percentage of intratumoral NRP1 (show NELL1 Antibodies)(+) Tregs correlates with poor prognosis in melanoma and head and neck squamous cell carcinoma.
Study revels the structural description of the neuropilin-1 (show NRP1 Antibodies) ectopic region by reporting the crystal structure of its MAM (show ATF7IP Antibodies) domain. The domain adopts a jellyroll fold that is stabilized by a Ca2 (show CA2 Antibodies)+ ion while forming a molecular surface that is distinct from its structural homologs.
NPTX1 is a member of the neuronal pentraxin gene family. Neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a binding protein for the snake venom toxin taipoxin. Human NPTX1 mRNA is exclusively localized to the nervous system.
47 kDa taipoxin-binding protein
, neuronal pentraxin 1
, neuronal pentraxin-1
, neuronal pentraxin I
, neuronal pentraxin 1 L homeolog