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anti-Human SH2B2 Antibodies:
anti-Mouse (Murine) SH2B2 Antibodies:
anti-Rat (Rattus) SH2B2 Antibodies:
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Studies indicate that insulin receptor (IR (show INSR Antibodies)) and IGF Type 1 Receptor (IGFR) have been identified as important partners of Grb10 (show GRB10 Antibodies)/14 and SH2B1 (show SH2B1 Antibodies)/B2 adaptors.
We present here a novel stimulatory mechanism of Vav3 (show VAV3 Antibodies) in which APS directly relieves the autoinhibitory CH domain and furthermore enhances its tyrosine phosphorylation by Lck (show LCK Antibodies).
N-terminal residues distal to the phosphotyrosine directly contact residues of the four-helix bundle of the TKB domain of the adapter protein (show TOLLIP Antibodies) APS
Deletion of liver SH2B1 (show SH2B1 Antibodies) in SH2B2 null mice attenuated very low-density lipoprotein (VLDL) secretion.
APS facilitates c-Cbl (show CBL Antibodies) tyrosine phosphorylation and GLUT4 (show SLC2A4 Antibodies) translocation in response to insulin (show INS Antibodies) in 3T3-L1 adipocytes
Data show that the adapter protein (show GRB10 Antibodies) APS preferentially associates with phosphorylated Tyr (show TYR Antibodies)-568 and Tyr (show TYR Antibodies)-936 of the receptor for stem-cell factor (show KITLG Antibodies) (c-Kit (show KIT Antibodies)).
Lnk (show SH2B3 Antibodies), SH2-B (show SH2B1 Antibodies), and APS have roles in mast cell development, growth, and functions
APS might have a novel regulatory role in actin reorganization and control of B-1 cell compartment size.
Knockdown of the mouse APS gene abolished the insulin (show INS Antibodies)-stimulated phosphorylation of c-Cbl (show CBL Antibodies).
APS appears to play novel negative regulatory roles in BCR signaling, actin reorganization pathways, and control of compartment sizes of B-lineage cells
These results identify Enigma as a novel APS-binding protein and suggest that the APS/Enigma complex plays a critical role in actin cytoskeleton organisation.
SH2-B (show SH2B1 Antibodies), but not APS, is a key positive regulator of energy and glucose metabolism in mice
APS enhanced ligand-dependent multi-ubiquitination of the insulin receptor (IR (show INSR Antibodies)) in CHO (show COL11A1 Antibodies) cells.
Association between variations in the SH2B2 gene and growth traits in Chinese cattle.
The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway.
SH2 and PH domain-containing adapter protein APS
, SH2B adapter protein 2
, adapter protein with pleckstrin homology and Src homology 2 domains
, adaptor protein with pleckstrin homology and src homology 2 domains
, insulin receptor substrate 5
, SH2B adaptor protein 2
, SH2B adapter protein 2-like