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Results show that a small subset of lymphoma cells surviving treatment with doxorubicin or phenylbutyrate showed stem cell-like properties and resistance to chemotherapeuty. The overexpression of FOXO4 was found in these surviving cells, and DLBCL patients with FOXO4-positive tumor cells had poor prognosis.
FOXO4 and FOXD3 (show FOXD3 Proteins) were shown independently predictive of overall survival in gastric cancer
FoxO1 (show FOXO1 Proteins) and FoxO4 antagonize Tat (show TAT Proteins)-mediated transactivation of HIV-1 promoter through the repression of Tat (show TAT Proteins) protein expression.
FOXO4 has an inhibitory effect in clearcell renal carcinoma cells, at least in part through inducing apoptosis via upregulation of Bim (show BCL2L11 Proteins) in the mitochondria-dependent pathway.
knockdown of Ku70 (show XRCC6 Proteins) inhibited cell proliferation accompanying an increase in p27(kip1 (show CDKN1B Proteins)) levels through interacting with FOXO4
miR (show MLXIP Proteins)-664 functions as an oncogene (show RAB1A Proteins) miRNA and has an important role in promoting human osteosarcoma cell proliferation by suppressing FOXO4 expression.
The data demonstrated that elevated miR (show MLXIP Proteins)-150 targets FOXO4 expression and therefore regulates multiple genes expression, resulting in cervical cancer cell growth and survival.
Porphyromonas gingivalis-induced reactive oxygen species activate FOXO (show FOXO3 Proteins) transcription factors through JNK (show MAPK8 Proteins) signalling, and that FOXO1 (show FOXO1 Proteins) controls oxidative stress responses, inflammatory cytokine production and cell survival.
Cox (show COX8A Proteins) regression analysis indicated FoxO4 to be an independent prognostic factor in non-small cell lung cancers and suggested that FoxO4 might inhibit the process of EMT (show ITK Proteins) in non-small cell lung cancers, and might therefore be a target for therapy.
FOXOs support the metabolic requirements of normal and tumor cells by promoting IDH1 (show IDH1 Proteins) expression.
Foxo1 (show FOXO1 Proteins), Foxo3a (show FOXO3 Proteins), and Foxo4 in chondrocytes regulate endochondral bone formation.
The effect of Sirt1 (show SIRT1 Proteins) stimulators on osteoclastogenesis was abrogated in cells lacking FoxO1 (show FOXO1 Proteins), FoxO3 (show FOXO3 Proteins), and FoxO4.
FoxO4 is collectively required to maintain MODYrelated gene networks, which in turn are required to enable a gene expression program that permits proper substrate selection (glucose versus fatty acids) for mitochondrial oxidative phosphorylation.
FoxO4 transcription factor is present during both oocyte and embryo in vivo maturation and FoxOs may regulate in vitro embryo development under stress conditions.
FoxO4 activates Arg1 (show ARG1 Proteins) transcription in endothelial cells in response to MI, leading to downregulation of nitric oxide and upregulation of neutrophil infiltration to the infarct area.
Foxo1, Foxo3, and Foxo4 transcriptional network regulates autophagy and the ubiquitin-proteasome system during muscle atrophy.
Liver-specific ablation of FoxO1 (show FOXO1 Proteins),FoxO3 (show FOXO3 Proteins) and FoxO4 prevents the induction of glucose-6-phosphatase (show G6PC Proteins) and the repression of glucokinase (show GCK Proteins) during fasting, thus increasing lipogenesis.
FOXO1 (show FOXO1 Proteins), FOXO3a (show FOXO3 Proteins) and FOXO4, are indispensable for SIRT1 (show SIRT1 Proteins)-dependent cell survival against oxidative stress.
FoxO1 (show FOXO1 Proteins)/3/4 transcription factors play important roles in hepatic glucose homeostasis.
Mice lacking Foxo1 (show FOXO1 Proteins), -3, and -4 in bipotential progenitors of osteoblast and adipocytes exhibit increased osteoblast number and high bone mass.
This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene.
similar to Putative fork head domain transcription factor AFX1 (Forkhead box protein O4)
, forkhead box O4
, forkhead box protein O4-like
, fork head domain transcription factor AFX1
, forkhead box protein O4
, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7
, forkhead protein
, myeloid/lymphoid or mixed lineage-leukemia translocation to 7 homolog
, forkhead box O1A