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Here, using zebrafish, murine, and human models, the authors show that erythropoietin (EPO (show EPO Proteins)) signaling, together with the GATA1 transcriptional target, AKAP10 (show AKAP10 Proteins), regulates heme biosynthesis during erythropoiesis at the outer mitochondrial membrane.
expression of GATA1 effectively rescued maturation of Primary myelofibrosis megakaryocytes.
GATA1 is an essential downstream target of SENP1 (show SENP1 Proteins) and that the differential expression and response of GATA1 and Bcl-xL (show BCL2L1 Proteins) are a key mechanism underlying chronic mountain sickness pathology.
we herein show a long-distance regulatory region with GATA1 binding sites as being a strong enhancer for NBEAL2 expression.
Single-nucleotide polymorphism in GATA1 gene is associated with non-Down syndrome transient proliferative megakaryoblastic disease.
These findings indicate that erythroid specific activator GATA-1 acts at CTCF (show CTCF Proteins) sites around the beta-globin (show HBB Proteins) locus to establish tissue-specific chromatin organization.
Results show that GATA1 recognizes a single GATA motif or a composite of adjacent GATA motifs and exerts its diversified bindings. These binding configurations serve as one of the critical determinants of specific transcriptional regulation.
Acquired and inherited GATA1 mutations contribute to Diamond-Blackfan anemia, acute megakaryoblastic leukemia, transient myeloproliferative disorder, and a group of related congenital dyserythropoietic anemias with thrombocytopenia.
Our results suggest that GATAl and miR (show MLXIP Proteins)-363 were involved in the regulation of hematopoiesis via the HIF-1alpha (show HIF1A Proteins) pathway in K562 cells under hypoxic condition.
analysis of GATA1 mutations in a cohort of Malaysian children with Down syndrome-associated myeloid disorder reveals distinctive genomic events
Gata1(low) mice are a bona fide model of MF, which recapitulates the hyperactivation of the TPO (show THPO Proteins)/MPL (show MPL Proteins)/JAK2 (show JAK2 Proteins) axis observed in megakaryocytes from myelofibrotic patients.
the Gata-1 gene was a T3-directly regulated gene and that TRa1PV could impair erythropoiesis via repression of the Gata-1 gene and its regulated genes. These results provide new insights into how TRa1 (show HSP90B1 Proteins) mutants acted to cause erythroid abnormalities in patients with mutations of the THRA (show THRA Proteins) gene.
Gain of function with GATA1 restores the common myeloid precursor differentiation into erythroblasts that was decreased by burn injury. There is a reciprocal relationship between myeloid-specific MafB (show MAFB Proteins) and erythroid-specific GATA1 in these cells. MafB (show MAFB Proteins) plays a role in dampening GATA1.
Gata1-KO(DC) DCs have reduced polysialic acid levels on their surface, which is a known determinant for the proper migration of DCs toward CCL21 (show CCL21 Proteins).
removal of the the Gata1 methylation-determining region -mediated silencing machinery is the molecular basis of the initial activation of the Gata1 gene and erythropoiesis.
deletion of P-sel disrupted megakaryocyte/neutrophil interactions in spleen, reduced TGF-beta (show TGFB1 Proteins) content, and corrected the hematopoietic stem cells distribution that in Gata1(low) mice, as in primary myelofibrosis patients, is abnormally expanded in spleen.
findings suggest that Gata1 & PU.1 transcription factors are only executing and reinforcing lineage choice once made. These results challenge the current prevailing model of early myeloid lineage choice
GATA1 and PU.1 bind in vitro and in vivo the proximal promoter region of the RPS19 (show RPS19 Proteins) gene which is frequently mutated in Diamond-Blackfan Anemia.
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia.
GATA-binding factor 1
, NF-E1 DNA-binding protein
, erythroid transcription factor
, erythroid transcription factor 1
, globin transcription factor 1
, nuclear factor, erythroid 1
, transcription factor GATA1
, GATA-binding protein 1
, GATA-binding protein 1 (globin transcription factor 1)
, GATA binding protein 1 (globin transcription factor 1)
, aspartyl/glutamyl-tRNA amidotransferase subunit A
, putative amidase
, glutamyl-tRNA amidotransferase subunit A
, hematopietic transcription factor GATA-1
, GATA 1 protein
, GATA binding protein 1
, GATA binding factor-1b
, GATA-binding factor 1-B
, transcription factor xGATA-1B
, LOW QUALITY PROTEIN: erythroid transcription factor-like
, erythroid-specific transcription factor eryf1