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CHMP4B Products

(Charged Multivesicular Body Protein 4B (CHMP4B))

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This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.[provided by RefSeq, Oct 2009].

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Featured CHMP4B Categories

CHMP4B Antibodies

High quality antibodies with extensive validation data.

CHMP4B Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CHMP4B Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Rat
Application ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro)
Validations
  • (4)
Cat. No. ABIN872575
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, FACS, IHC (p)
Validations
  • (1)
  • (3)
Cat. No. ABIN653481
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (4)
Cat. No. ABIN6138549
Quantity 100 μL
Datasheet Datasheet

Recommended CHMP4B ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6228058
Quantity 96 tests
Datasheet Datasheet

Recommended CHMP4B Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2713984
Quantity 20 μg
Datasheet Datasheet
Reactivity Zebrafish (Danio rerio)
Source Yeast
Validations
Cat. No. ABIN1677542
Quantity 1 mg
Datasheet Datasheet
Reactivity Chicken
Source Yeast
Validations
Cat. No. ABIN1635181
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our CHMP4B products

Hu, Jiang, Chen, Wei, Zhang, Zhao, Ni, Lu, Wan: "High CHMP4B expression is associated with accelerated cell proliferation and resistance to doxorubicin in hepatocellular carcinoma." in: Tumour biology, Vol. 36, Issue 4, pp. 2569-81, (2015) (PubMed).

Bodon, Chassefeyre, Pernet-Gallay, Martinelli, Effantin, Hulsik, Belly, Goldberg, Chatellard-Causse, Blot, Schoehn, Weissenhorn, Sadoul: "Charged multivesicular body protein 2B (CHMP2B) of the endosomal sorting complex required for transport-III (ESCRT-III) polymerizes into helical structures deforming the plasma membrane." in: The Journal of biological chemistry, Vol. 286, Issue 46, pp. 40276-86, (2011) (PubMed).

Synonyms and alternative names related to CHMP4B

charged multivesicular body protein 4B (CHMP4B), charged multivesicular body protein 4B (Chmp4b), charged multivesicular body protein 4Ba (chmp4ba), charged multivesicular body protein 4B L homeolog (chmp4b.L), charged multivesicular body protein 4Bb (chmp4bb), 2010012F05Rik, C20orf178, c20orf178, C76846, CHMP4A, CHMP4b, chmp4b, chmp4b.S, CHMP4c, CTPP3, CTRCT31, dJ553F4.4, RGD1309846, RGD1565889, Shax1, SNF7, SNF7-2, Snf7-2, Vps32-2, VPS32B, wu:fc96b02, zgc:55566

Protein level used designations for CHMP4B

  • SNF7 homolog associated with Alix 1
  • Snf7 homologue associated with Alix 1
  • charged multivesicular body protein 4b
  • chromatin modifying protein 4B
  • chromatin-modifying protein 4b
  • hSnf7-2
  • hVps32-2
  • vacuolar protein sorting-associated protein 32-2
  • vacuolar protein-sorting-associated protein 32-2
  • CHMP4b
  • Chromatin-modifying protein 4b
  • charged multivesicular body protein 4B S homeolog
  • CHMP4c
  • Chromatin-modifying protein 4c
  • charged multivesicular body protein 4B
  • charged multivesicular body protein 4c
  • chromatin-modifying protein 4c
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