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anti-Human FOXC1 Antibodies:
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Human Polyclonal FOXC1 Primary Antibody for ChIP, ELISA - ABIN249940
Dagenais, Hartsough, Erickson, Witte, Butler, Glover: Foxc2 is expressed in developing lymphatic vessels and other tissues associated with lymphedema-distichiasis syndrome. in Gene expression patterns : GEP 2004
Show all 10 Pubmed References
Human Polyclonal FOXC1 Primary Antibody for ICC, IF - ABIN4312329
DeGraff, Grabowska, Case, Yu, Herrick, Hayward, Strand, Cates, Hayward, Gao, Walter, Buttyan, Yi, Kaestner, Matusik: FOXA1 deletion in luminal epithelium causes prostatic hyperplasia and alteration of differentiated phenotype. in Laboratory investigation; a journal of technical methods and pathology 2014
Knockdown of FOXC1 markedly suppressed cell migration and invasion in vitro, and resulted in downregulation of phosphorylatedRACalpha serine/threonineprotein kinase, protooncogene cMyc (show MYC Antibodies) and Bcell lymphoma 2.
Results provide evidence that FOXC1 is not required for initiation of EMT (show ITK Antibodies) events but rather participates in the specification of mesenchymal cell phenotype through regulation of FGF receptor (show FGFR2 Antibodies) switching from FGFR2 (show FGFR2 Antibodies)-IIIb to FGFR1 (show FGFR1 Antibodies)-IIIc in response to TGFb1 (show TGFB1 Antibodies)-induced EMT (show ITK Antibodies).
In regulating cervical cancers metastasis by targeting FOXC1.
Forkhead box C1 protein (FOXC1) promotes melanoma cell function by regulating macrophage stimulating 1 receptor (MST1R (show MST1R Antibodies)) and activating MST1R (show MST1R Antibodies)/PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) pathway.
expression of FOXC1 in BRCA1 mutant cell lines correlates with sensitivity to olaparib. Whether this is due to rates of proliferation or another mechanism is yet to be explored, but this, and the specificity of FOXC1 in BRCA1-mutant tumors, suggests a possible role for FOXC1 as a marker for targeted therapy.
novel EGFR (show EGFR Antibodies)-NF-kappaB (show NFKB1 Antibodies)-FOXC1 signaling axis that is critical for BLBC cell function
Taken together, these data indicate that FOXC1 is a novel hypoxia-induced transcription factor and plays a critical role in tumor microenvironment-promoted lung cancer progression.
Genomic analysis of blood and excised valve tissue showed down-regulation of FOXC1 but also FOXC2 (show FOXC2 Antibodies) expression in the diseased aortic valve. This allows us to speculate on the potential role of FOXC1 in aortic valve anomalies.
Results showed a significant higher FOXC1 expression in estrogen receptor (show ESR1 Antibodies)-negative breast cancer than that in estrogen receptor (show ESR1 Antibodies)-positive. Its overexpression reduced expression of ERalpha (show ESR1 Antibodies) and cellular responses to tamoxifen suggesting that FOXC1 regulated expression of ERalpha (show ESR1 Antibodies) and affected sensitivity of tamoxifen treatment in breast cancer
present work reveals that FOXC1 is an important regulator of exocytosis and establishes a new link between FOXC1 and MYOC (show MYOC Antibodies)-associated glaucoma
Lineage tracing experiments in Foxc1 mutant mouse cerebella indicate that aberrant migration of granule cell progenitors destined to form the posterior-most lobule causes this cerebellar malformation phenotype.
Foxc1 regulates both early cardiomyogenesis and the functional properties of embryonic stem cell-derived cardiomyocytes.
FOXC1 and FOXC2 (show FOXC2 Antibodies) are essential regulators of lymphangiogenesis and may have roles in lymphatic-associated diseases
These data indicate that Foxc1 expression is regulated by BMP4 (show BMP4 Antibodies) and FOXC1 functions in the commitment of progenitor cells to the osteoblast fate and its expression is reduced when differentiation proceeds.
Foxc1 regulates sweat duct luminal cell differentiation and mimic apocrine miliaria.
Compound, NC-specific Foxc1; Foxc2 (show FOXC2 Antibodies) homozygous mutant mice have more severe defects in structures of the ocular surface, such as the cornea and eyelids, accompanied by significant declines in the expression of another key developmental factor, Pitx2 (show PITX2 Antibodies), and its downstream effector Dkk2 (show DKK2 Antibodies), which antagonizes canonical Wnt (show WNT2 Antibodies) signaling.
These findings offer the first evidence for a role of the meninges in brain vascular development and provide new insight into potential causes of cerebrovascular defects in patients with FOXC1 mutations.
Foxc1 and Foxc2 (show FOXC2 Antibodies) maintain glomerular podocyte integrity by regulating the gene expression.
Foxc1 and Foxc2 (show FOXC2 Antibodies) have a role in kidney and axial skeleton development.
FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential.FOXC1 is necessary to establish a multiple-bulge hair follicle architecture.
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined\; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly.
forkhead box protein C1
, forkhead box C1
, Forkhead box protein C1
, forkhead, drosophila, homolog-like 7
, forkhead-related activator 3
, forkhead-related protein FKHL7
, forkhead-related transcription factor 3
, forkhead/winged helix-like transcription factor 7
, myeloid factor-delta
, congenital hydrocephalus
, mesoderm/mesenchyme forkhead 1
, transcription factor FKH-1
, forkhead box protein C1-B
, winged helix protein CWH-6
, winged-helix transcription factor