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Results demonstrate the existence of crosstalk between beta-catenin signaling and HGS in two different types of cancer (hepatoblastoma and colorectal).
ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM (show STAM Antibodies)) and the complex formation with STAM (show STAM Antibodies) promotes its endosomal dissociation.
we identified an interaction between EsxH, which is secreted by the Esx-3 TSSS, and human hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs/Hrs), a component of the endosomal sorting complex required for transport (ESCRT).
the role for tumoral c-Met expression or sMet/HGF (show HGF Antibodies) levels as upfront selection criterion or predictive biomarkers deserve further study in this emerging area of therapeutic focus in RCC (show XRCC1 Antibodies)
Hrs tyrosine phosphorylation detected upon EGF (show EGF Antibodies)-stimulation.
Hrs inhibits HIV-1 production by inhibiting citron kinase (show CIT Antibodies)-mediated exocytosis.
ESCRT-0 component HRS is required for HIV-1 Vpu-mediated BST-2/tetherin (show BST2 Antibodies) down-regulation.
Plasma hepatocyte growth factor (show HGF Antibodies) is associated with periampullary cancer.
hSpry2 binds to the endocytic regulatory protein, hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) and blocks intracellular signal propagation.
The HRS domain required for merlin (show NF2 Antibodies) binding is narrowed to a region (residues 470-497) containing the predicted coiled-coil domain whereas the major domain responsible for HRS growth suppression is distinct (residues 498-550).
Findings find that Hrs is indispensable for the autophagic clearance of neurodegeneration-related proteins and for the survival of hippocampal neurons in mammals. In particular, the work provides the novel insight that the loss of Hrs results in insufficient autophagic clearance and enhanced ER stress, thereby triggering JNK (show MAPK8 Antibodies) activation and subsequent apoptotic and necroptotic neuronal cell death.
HGS expression in the nervous system is developmentally regulated.HGS is required for motor neuron function.
Smooth Muscle Hgs Deficiency Leads to Impaired Esophageal Motility.
A new mechanism to modify BMP signaling by Hgs during early mouse development.
Hrs is a master molecule that controls in part the degradation of STAM1 (show STAM Antibodies) and the accumulation of ubiquitinated proteins
Data suggest that Hrs regulates the KGFR (show FGFR2 Antibodies) degradative pathway, but not its juxtanuclear recycling transport, and that Hrs recruitment to the receptor, but not its ligand-induced phosphorylation, could be required for its function.
Nedd4-2 (show NEDD4L Antibodies) induces binding of ENaC (show SCNN1A Antibodies) to Hrs, which mediates the sorting decision between ENaC (show SCNN1A Antibodies) degradation and recycling.
Peptidergic versus nonpeptidergic specification depends on a balance between HGF (show HGF Antibodies)-Met signaling and Runx1 (show RUNX1 Antibodies) extinction/maintenance in primary nociceptive neurons.
Src (show SRC Antibodies) phosphorylates Hrs in vitro & in vivo. Hrs is phosphorylated in Src (show SRC Antibodies)-, Yes- & Fyn (show FYN Antibodies)-negative cells. 10-20% is phosphorylated after EGF (show EGF Antibodies) stimulation at multiple tyrosines in different parts of Hrs by several kinases downstream of the EGF receptor (show EGFR Antibodies).
The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation.
, HGF/SF receptor
, SF receptor
, hepatocyte growth factor receptor
, met proto-oncogene tyrosine kinase
, proto-oncogene c-Met
, scatter factor receptor
, tyrosine-protein kinase Met
, hepatoCyte growth factor receptor
, met proto-oncogene
, Hepatocyte growth factor receptor
, hepatocyte growth factor receptor-like
, Proto-oncogene c-Met
, Scatter factor receptor
, Tyrosine-protein kinase Met
, human growth factor-regulated tyrosine kinase substrate
, protein pp110
, HGF-regulated tyrosine kinase substrate
, SNAP-25-interacting protein Hrs-2
, hepatocyte growth factor-regulated tyrosine kinase substrate