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Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage leads to the ubiquitination of PLK1, preventing entry into mitosis (By similarity).
fizzy-related protein homolog
, fizzy/cell division cycle 20 related 1 (Drosophila)
, fizzy-related protein FZR
, Fizzy-related protein-like protein
, fizzy/cell division cycle 20 related 1
, CDC20-like 1b
, CDC20-like protein 1
, cdh1/Hct1 homolog
, cell division cycle 20 related 1