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Loss of SNX-1, RME-8, or the clathrin chaperone Hsc70/HSP-1 leads to over-accumulation of endosomal clathrin, reduced clathrin dynamics, and missorting of MIG-14 to the lysosome.
The development of transgenic zebrafish lines expressing CLTA fused to dsRed and CAV1 fused to GFP is reported.
Clathrin plays a crucial role in meiotic spindle function in maturing oocytes, possibly through spindle stabilization
Data indicate that clathrin-mediated endocytosis of proto-oncogene protein erbB-3 (ErbB3) is depending on epsin-1.
Upon receptor activation, prostate alpha1A-adrenoceptors bind clathrin LCA.
IGF1R internalization and co-localization with clathrin and CAV1 upon ligand binding, as well as the status of the IGF1R pathway, cellular proliferation, and the apoptosis of interfered and inhibited Ewing's sarcoma, were analyzed.
upon ligand activation, CysLT(1)R is tyrosine-phosphorylated and released from heterodimers with CysLT(2)R and, subsequently, internalizes from the plasma membrane to the nuclear membrane in a clathrin-, arrestin-3-, and Rab-5-dependent manner
Data show that MAD2B interacts with CLTA during the G2/M phase of the cell cycle and that depletion of MAD2B leads to a marked increase in the percentage of misaligned chromosomes and a redistribution of CLTA during mitosis.
Human Rhinovirus 2 uses clathrin-mediated endocytosis to infect cells
Data suggest that clathrin heavy chains bound to light chains (LC) a and b contribute to pit formation, but the affinity of LCa-free HC in pits is reduced, and the Ca(2+)- and ATP-mediated control of clathrin function is lost.
in mammalian cells CLCs function in intracellular membrane trafficking by acting as recruitment proteins for HIP1R, enabling HIP1R to regulate actin assembly on clathrin-coated structures
Structure of clathrin coat with bound Hsc70 and auxilin.
Based on circular dichroism data, mapping and mutagenesis, bovine LCa and LCb were represented as alpha-helices, aligned along the heavy chain. A structural model of the interaction was generated with new implications for LC control of clathrin assembly.
Binding of light chain increases the amount of detergent needed to induce detrimerization, suggesting light chains reinforced hub trimers.
Clathrin light chains' role in selective endocytosis influences antibody isotype switching.
Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12.
Clathrin LIght Chain family member (clic-1)
, clathrin, light chain (Lca)
, clathrin, light polypeptide A
, light chain (Lca)
, clathrin light chain A
, clathrin, light polypeptide (Lca)
, clathrin light chain
, Clathrin light chain
, clathrin, light chain A2
, clathryn light chain (LCA2)