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Human Monoclonal Mesothelin Primary Antibody for FACS - ABIN4897254
Cherkassky, Morello, Villena-Vargas, Feng, Dimitrov, Jones, Sadelain, Adusumilli: Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition. in The Journal of clinical investigation 2016
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Human Monoclonal Mesothelin Primary Antibody for IHC (p), IHC - ABIN259911
Ho, Bera, Willingham, Onda, Hassan, FitzGerald, Pastan: Mesothelin expression in human lung cancer. in Clinical cancer research : an official journal of the American Association for Cancer Research 2007
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Human Polyclonal Mesothelin Primary Antibody for IHC, IHC (p) - ABIN4333902
Feng, Zhang, Anver, Hassan, Ho: In vivo imaging of human malignant mesothelioma grown orthotopically in the peritoneal cavity of nude mice. in Journal of Cancer 2011
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Chimpanzee Polyclonal Mesothelin Primary Antibody for ELISA, IF - ABIN1583503
Rinkevich, Mori, Sahoo, Xu, Bermingham, Weissman: Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells and fibroblasts for mammalian internal organs, and their vasculature. in Nature cell biology 2013
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Human Monoclonal Mesothelin Primary Antibody for IHC, WB - ABIN233753
Xiang, Phung, Feng, Nagashima, Zhang, Broaddus, Hassan, Fitzgerald, Ho: The Development and Characterization of a Human Mesothelioma In Vitro 3D Model to Investigate Immunotoxin Therapy. in PLoS ONE 2011
Human Polyclonal Mesothelin Primary Antibody for ELISA, WB - ABIN4333900
Cheng, Huang, Chang, Hu, Chiang, Chen, Hsieh, Chen: High mesothelin correlates with chemoresistance and poor survival in epithelial ovarian carcinoma. in British journal of cancer 2009
Human Monoclonal Mesothelin Primary Antibody for FACS - ABIN4897250
Servais, Suzuki, Colovos, Rodriguez, Sima, Fleisher, Rusch, Sadelain, Adusumilli: An in vivo platform for tumor biomarker assessment. in PLoS ONE 2011
Human Monoclonal Mesothelin Primary Antibody for FACS - ABIN4897252
Takenouchi, Hirai, Sakuragi, Yagita, Hamada, Kato: Epigenetic modulation enhances the therapeutic effect of anti-IL-13R(alpha)2 antibody in human mesothelioma xenografts. in Clinical cancer research : an official journal of the American Association for Cancer Research 2011
Our goal was to stimulate antitumor immunity by combining SS1P or LMB-100 with anti-CTLA-4 (show CTLA4 Antibodies). We constructed a BALB/c breast cancer cell line expressing human mesothelin (66C14-M), which was implanted in one or two locations. SS1P or LMB-100 was injected directly into established tumors and anti-CTLA-4 (show CTLA4 Antibodies) administered i.p. In mice with two tumors, one tumor was injected with immunotoxin and the other was not.
Mesothelin-targeted immunotoxin RG7787 increases pancreatic cancer cell sensitivity to taxane-mediated killing by increasing taxane-mediated microtubule stability and priming cells for apoptosis by decreasing levels of the pro-survival factor Mcl-1 (show MCL1 Antibodies).
RG7787 plus nab-paclitaxel is very active against primary human mesothelioma cells in vitro as well as in vivo, with serum mesothelin levels correlating with tumor response. These results indicate that this combination could be useful for treating patients with mesothelioma
Efficient growth suppression in pancreatic cancer PDX model by fully human anti-mesothelin CAR-T cells.
Mesothelin/mucin 16 (show MUC16 Antibodies) signaling in activated portal fibroblasts regulates cholestatic liver fibrosis.(
MiR (show MLXIP Antibodies)-21-5p is suggested as novel regulator of MSLN with a possible functional role in cellular growth.
we report herein that high tumor mesothelin expression predicts a shorter PFS and OS in EOC patients and demonstrates that serum mesothelin predicts local tumor mesothelin expression.
We provide new evidence for the role of MSLN in EMT (show ITK Antibodies) regulation, tumorigenesis and metastasis. Knockdown of MSLN led to mesenchymal to epithelial transition and less aggressive behavior of lung carcinoma and mesothelioma cells.
MSLN expression increases cell migration and invasion in vitro.
SMRP (show ABCC5 Antibodies) but not FBLN3 (show FBLN3 Antibodies) has a role in pleural effusions in in malignant pleural mesothelioma
our findings show that Sulf-1 (show SULF1 Antibodies) is an important tumor suppressor gene in hepatocellular carcinoma (HCC (show FAM126A Antibodies)), and its over expression downregulates Msln and results in a decrease in HCC (show FAM126A Antibodies) cell proliferation, migration, invasion, and lymphatic metastasis.
Results show that mouse mesothelin is similar to human mesothelin. Its stable overexpression in a pancreatic cancer cell line did not increase cell proliferation, suggesting that mesothelin is not necessarily a tumor progression factor.
MSLN has an important role in the growth of lung cancer cells in vivo raising the possibility that inactivation of MPF may be a useful treatment for lung and other MSLN expressing cancers.
The mesothelin expression promotes resistance to certain chemotherapy drugs such as TNF-alpha (show TNF Antibodies), paclitaxel, and a combination of platinum and cyclophosphamide.
Mesothelin overexpression promotes mesothelioma cell invasion and MMP-9 (show MMP9 Antibodies) secretion.
Data show that mesothelin is a potential target in reducing resistance to cytotoxic drugs, and mesothelin-treated cells revealed rapid tyrosine phosphorylation of the p85 (show ECM1 Antibodies) subunit of PI3K.
binding of membrane-bound mesothelin to ovarian cancer antigen CA125 (show MUC16 Antibodies) mediates heterotypic cell adhesion
This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.
, megakaryocyte potentiating factor
, pre-pro-megakaryocyte-potentiating factor
, soluble MPF mesothelin related protein
, protein expressed in renal carcinoma