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Su, Wu, Hong: Betanodavirus up-regulates chaperone GRP78 via ER stress: roles of GRP78 in viral replication and host mitochondria-mediated cell death. in Apoptosis : an international journal on programmed cell death 2011
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Okle, Stemmer, Deschl, Dietrich: L-BMAA induced ER stress and enhanced caspase 12 cleavage in human neuroblastoma SH-SY5Y cells at low nonexcitotoxic concentrations. in Toxicological sciences : an official journal of the Society of Toxicology 2013
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Human CASP12 ELISA Kit for Sandwich ELISA - ABIN367356
Du, Guo, Wu, Liu, Bi: Zinc chloride inhibits human lens epithelial cell migration and proliferation involved in TGF-β1 and TNF-α signaling pathways in HLE B-3 cells. in Biological trace element research 2014
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mice ablated for caspase-12 develop spontaneous obesity and insulin (show INS ELISA Kits) resistance.
Bnip3L (show BNIP3L ELISA Kits) and caspase-12 identified by the PCR arrays at both catagen stages were additionally localized using immunofluorescence and were reported in physiological hair development for the first time.
Caspase-12 plays a pivotal role in CCl4 (show CCL4 ELISA Kits)-induced hepatic apoptosis through the activation of the downstream effector caspase-3 (show CASP3 ELISA Kits) directly and/or indirectly via caspase-9 (show CASP9 ELISA Kits) activation.
We validated caspase-12 as a therapeutic target, ablation of which significantly protects T17M photoreceptors from deterioration.
Findings an increase in multiple unfolded protein response pathways in muscles of the dystrophin (show DMD ELISA Kits)-deficient mdx (show DMD ELISA Kits) mouse, the model for Duchenne muscular dystrophy (show DMD ELISA Kits).
Tauroursodeoxycholic acid intervention down-regulated GRP78 (show HSPA5 ELISA Kits) and CHOP (show DDIT3 ELISA Kits) expression and Caspase 12 activation.
Findings indicate that although caspase-12 deficiency results in enhanced pro-inflammatory and immunoregulatory cytokine levels in sera during P. yoelii 17XL infection, these responses are not essential for protection against lethal malaria infection.
caspase-12 competed with NEMO (show IKBKG ELISA Kits) for association with IkappaB kinase-alpha (show CHUK ELISA Kits)/beta, effectively preventing the formation of the IkappaB kinase (show CHUK ELISA Kits) complex and inhibiting downstream transcriptional activation by NF-kappaB (show NFKB1 ELISA Kits).
Caspase-12 was required for an effective antiviral immune response, especially for the production of type I interferons through the regulation of TRIM25 (show TRIM25 ELISA Kits)-mediated ubiquitination of RIG-I (show DDX58 ELISA Kits). .
Matrix metalloproteinase-3 (show MMP3 ELISA Kits) is increased and participates in neuronal apoptotic signaling downstream of caspase-12 during endoplasmic reticulum stress
cysteine-aspartic acid protease (caspase); involved with the terminal stage of apoptosis