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DNAJC3 p.H238N is likely to be a variant causing diabetes.
p58IPK is a general inhibitor of the eIF2alpha kinases in that it also interacts with GCN2. Thus forced overexpression of cytoplasmic p58 delays eIF2alpha phosphorylation, suppresses GCN2 phosphorylation and prolongs protein synthesis
Loss-of-function DNAJC3 mutations lead to a monogenic, recessive form of diabetes mellitus in humans.
p58 (show CDK11B Proteins)(IPK) suppresses coxsackievirus B3-induced apoptosis through selective activation of PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway that requires activation of ATF6a (show ATF6 Proteins) and subsequently upregulates mitofusin 2 (show MFN2 Proteins).
interplay between p38 (show CRK Proteins) phosphorylation and p58 (show CDK11B Proteins)(IPK) upregulation has key roles in modulating ERp29 (show ERP29 Proteins)-induced cell-growth arrest and survival
the crystal structure of human P58 (show CDK11B Proteins)(IPK)
Coxsackievirus B3 infection induces apoptosis through downregulation of p58IPK and activation of CHOP (show DDIT3 Proteins) and SREBP1 (show SREBF1 Proteins).
Spleen cells from transgenic mice overexpressing (Hu)PKR were studied and compared to those from wild-type mice after drug treatment. Dact-treated spleen cells were resistant to apoptosis; ConA-treated cells had decreased cell division.
P58 (show CDK11B Proteins)(IPK) is an important component of a negative feedback loop used by the cell to inhibit eIF2alpha (show EIF2A Proteins) signaling, and thus attenuate the unfolded protein response.
The study demonstrates that P58 (show CDK11B Proteins)(IPK) inhibits endoplasmic reticulum (ER) stress and plays an important role in maintaining balance and stability of the ER in human retinal capillary endothelial cells.
Cloning, prokaryotic expression of novel swine gene P58IPK and its polyclonal antibody preparation
Chaperone protein p58 (show CDK11B Proteins)(IPK) is expressed predominantly in retinal ganglion cells (RGC), inner retinal neurons, and the photoreceptor inner segments.
combined deletion of ATF6alpha (show ATF6 Proteins) and the ER cochaperone p58 (show CDK11B Proteins)(IPK) resulted in synthetic embryonic lethality.
Data present a working model for P58 (show CDK11B Proteins)(IPK) to act together with Bip (show HSPA5 Proteins) to prevent protein aggregations and promote protein foldings within ER.
mechanism by which P58 (show CDK11B Proteins)(IPK) functions to promote protein folding within the endoplasmic reticulum, determined from the crystal structure of P58 (show CDK11B Proteins)(IPK)
renal injury inflicted by expression of the folding mutants was markedly enhanced by haploinsufficiency of the endoplasmic reticulum cochaperone p58 (show CDK11B Proteins)(IPK).
The stress of unfolded proteins in the ER activates P58(IPK) transcription through an ER stress-response element in its promoter. P58(IPK) interacts with & inhibits PERK, which protects cells during the ER-stress response by reducing protein synthesis.
Insulin (show INS Proteins) deficiency associated with the absence of P58 (show CDK11B Proteins)(IPK) mimics beta-cell failure associated with type 1 and late-stage type 2 diabetes.
absence of P58 (show CDK11B Proteins)(IPK) led to an increase in eIF2alpha (show EIF2A Proteins) phosphorylation and decreased influenza virus mRNA translation
This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR).
dnaJ homolog subfamily C member 3
, endoplasmic reticulum DnaJ protein 6
, interferon-induced, double-stranded RNA-activated protein kinase inhibitor
, protein kinase inhibitor of 58 kDa
, protein kinase inhibitor p58
, protein-kinase, interferon-inducible double stranded RNA dependent inhibitor
, DnaJ (Hsp40) homolog, subfamily C, member 3
, Interferon-induced, double-stranded RNA-activated protein kinase inhibitor
, TPR repeat-containing protein
, DnaJ (Hsp40) homolog, subfamily C, member 3A
, DnaJ (Hsp40) homolog, subfamily C, member 3B
, protein kinase, interferon inducible double stranded RNA dependent inhibitor