(FIG4 Homolog, SAC1 Lipid Phosphatase Domain Containing (FIG4))
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Latest Publications for our FIG4 products: "Loss of Fig4 in both Schwann cells and motor neurons contributes to CMT4J neuropathy." in: Human molecular genetics, Vol. 24, Issue 2, pp. 383-96, (2014) (PubMed).
: "Characterization of a de novo SCN8A mutation in a patient with epileptic encephalopathy." in: Epilepsy research, Vol. 108, Issue 9, pp. 1511-8, (2014) (PubMed).
: "Murine Fig4 is dispensable for muscle development but required for muscle function." in: Skeletal muscle, Vol. 3, Issue 1, pp. 21, (2013) (PubMed).
: "Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B." in: Journal of medicinal chemistry, Vol. 55, Issue 21, pp. 9312-30, (2012) (PubMed).
: "In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 43, pp. 17472-7, (2012) (PubMed).
: "Pathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4J." in: PLoS genetics, Vol. 7, Issue 6, pp. e1002104, (2011) (PubMed).
: "Trauma does not accelerate neuronal degeneration in Fig4 insufficient mice." in: Journal of the neurological sciences, Vol. 312, Issue 1-2, pp. 102-7, (2011) (PubMed).
: "Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathies." in: PLoS genetics, Vol. 7, Issue 10, pp. e1002319, (2011) (PubMed).
Synonyms and alternative names related to FIG4FIG4 phosphoinositide 5-phosphatase (Fig4), FIG4 phosphoinositide 5-phosphatase (FIG4), A530089I17Rik, AI326867, ALS11, CMT4J, dJ249I4.1, KIAA0274, Kiaa0274, RGD1311375, Sac3, SAC3, YVS
Protein level used designations for FIG4
- SAC domain-containing protein 3
- Sac domain-containing inositol phosphatase 3
- phosphatidylinositol 3,5-bisphosphate 5-phosphatase
- polyphosphoinositide phosphatase
- FIG4 homolog, SAC domain containing lipid phosphatase
- FIG4 homolog, SAC1 domain containing lipid phosphatase
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