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anti-Mouse (Murine) GNAI1 Antibodies:
anti-Human GNAI1 Antibodies:
anti-Rat (Rattus) GNAI1 Antibodies:
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Human Polyclonal GNAI1 Primary Antibody for ELISA, WB - ABIN561067
Sasaki, Yamasaki, Omotuyi, Mishina, Ueda: Age-dependent dystonia in striatal G?7 deficient mice is reversed by the dopamine D2 receptor agonist pramipexole. in Journal of neurochemistry 2013
Human Polyclonal GNAI1 Primary Antibody for WB - ABIN4890045
Hurst, Henkel, Brown, Hooks: Endogenous RGS proteins attenuate Galpha(i)-mediated lysophosphatidic acid signaling pathways in ovarian cancer cells. in Cellular signalling 2008
Human Polyclonal GNAI1 Primary Antibody for IHC, IHC (p) - ABIN441599
Matsumura, Kojidani, Kamioka, Uchida, Haraguchi, Kimura, Toyoshima: Interphase adhesion geometry is transmitted to an internal regulator for spindle orientation via caveolin-1. in Nature communications 2016
Gnai1 function is impaired in the spinal cord of Ews/Ewsr1 (show EWSR1 Antibodies) KO mice
LGN (show GPSM2 Antibodies) and Galphai participate in a long-inferred signal that originates outside the bundle to model its staircase-like architecture, a property that is essential for direction sensitivity to mechanical deflection and hearing.
stimulation of GPR17 (show GPR17 Antibodies) by the small molecule agonist MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid) decreases myelin basic protein (show MBP Antibodies) expression levels mainly by triggering the Galphai/o signaling pathway.
Gnai1 missense mutation is responsible of hyperpigmentation in mouse model.
acidosis in inflamed tissues may be a decisive factor to regulate switching of PKA and PKCepsilon dependence via proton-sensing G-protein-coupled receptors.
Data show that guanine nucleotide-binding protein G(i) subunit alpha-1 and alpha-3 (Galphai1/3) can interact with CD14 antigen/Grb2-associated binding protein Gab1, which modulates macrophage polarization in vitro and in vivo.
By using mice deficient in individual Galphai/o G-protein subunits, authors demonstrate that Galphai1 and Galphai3 are the critical in vivo targets of ADP-ribosylation underlying vasoactive amine sensitization elicited by pertussis toxin exposure.
leucine can directly facilitate insulin (show INS Antibodies) signaling through a Galphai protein-dependent intracellular signaling pathway
Inactive Galpha(i1)-GDP enhances the affinity of RGS14 for H-Ras-GTP in live cells, resulting in a ternary signaling complex that is further regulated by G protein-coupled receptors.
Mice with mutations of Gnai1 or Gnai2 (show GNAI2 Antibodies) have neither fusions of ribs nor lumbar vertebrae, but loss of both Gnai3 (show GNAI3 Antibodies) and one of the other two genes increases the number and severity of rib fusions without affecting the lumbar fusions.
GIV (show CCDC88A Antibodies) is a bifunctional modulator of G proteins; it serves as a guanine nucleotide dissociation inhibitor (GDI) for Galphas (show GNAS Antibodies) using the same motif that allows it to serve as a guanine-nucleotide exchange factor (show RASGRF1 Antibodies) for Galphai
The authors demonstrate that Glu53, Glu60, and Glu118 of human Ngb (show GTPBP4 Antibodies) are crucial for both the neuroprotective activity and interaction with Gi. Moreover, they show that Lys46, Lys70, Arg208, Lys209, and Lys210 residues of Gi are important for binding to human Ngb (show GTPBP4 Antibodies).
GTP (show AK3 Antibodies) analogs leads to a rigid and closed arrangement of the Galphai1, whereas the apo (show C9orf3 Antibodies) and GDP-bound forms are considerably more open and dynamic.
The results show ZIP9 (show SLC39A9 Antibodies) is a specific Gi coupled-membrane AR mediating testosterone-induced MAP kinase (show MAPK1 Antibodies) and zinc signaling in PC3 (show PCSK1 Antibodies)-ZIP9 (show SLC39A9 Antibodies) cells.
These data indicate that, unlike in taste cells, TAS2Rs couple to the prevalent G proteins, Galphai1, Galphai2 (show GNAI2 Antibodies), and Galphai3 (show GNAI3 Antibodies), with no evidence for functional coupling to Galphagust.
testosterone rapidly increased whole-cell HCAEC SKCa and BKCa (show KCNMA1 Antibodies) currents via a surface androgen receptor (show AR Antibodies), Gi/o protein, and protein kinase A
These findings suggest that Gi1 interacts only with active GPCRs and that the well known high speed of GPCR signal transduction does not require preassembly between G proteins and GPCRs.
CGRP (show S100A12 Antibodies) family of receptors displays both ligand- and RAMP-dependent signaling bias among the Galphas (show GNAS Antibodies), Galphai, and Galphaq (show GNAQ Antibodies)/11 pathways.
biochemical and computational data indicate that the interactions between alpha5, alpha1, and beta2-beta3 are not only vital for GDP release during G protein activation, but they are also necessary for proper GTP binding (show RND2 Antibodies) (or GDP rebinding).
Data indicate that hydroxyurea (HU) induces SAR1 (show IQGAP1 Antibodies) protein expression, which in turn activates gamma-globin (show HBG1 Antibodies) expression, predominantly through the Gialpha/JNK (show MAPK8 Antibodies)/Jun (show JUN Antibodies) pathway.
Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded protein is part of a complex that responds to beta-adrenergic signals by inhibiting adenylate cyclase. Two transcript variants encoding different isoforms have been found for this gene.
adenylate cyclase-inhibiting G alpha protein
, guanine nucleotide binding protein, alpha inhibiting 1
, guanine nucleotide-binding protein G(i) subunit alpha-1
, Gi1 protein alpha-subunit
, alpha-subunit of G-protein, type G-alpha-i-1
, guanine nucleotide-binding protein G(i), alpha-1 subunit
, Gi1 protein alpha subunit
, Gi-alpha-1 protein
, guanine nucleotide binding protein (G protein), alpha inhibiting 1
, Galpha i1a