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HCST Products

(Hematopoietic Cell Signal Transducer (HCST))
This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

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Featured HCST Categories

HCST Antibodies

High quality antibodies with extensive validation data.

HCST ELISA Kits

Reliable ELISA kits for a wide range of species.

HCST Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended HCST Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Rat
Application WB, FACS, IF (cc), IF (p), ELISA, IHC (fro), IHC (p), ICC
Validations
  • (1)
Cat. No. ABIN2175291
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Rat
Application WB, ELISA, IHC (fro), IHC (p)
Validations
Cat. No. ABIN2175296
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Rat
Application WB, FACS, IF (cc), IF (p)
Validations
Cat. No. ABIN2175293
Quantity 100 μL
Datasheet Datasheet

Recommended HCST ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1136280
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1136281
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method
Validations
Cat. No. ABIN1136283
Quantity 96 tests
Datasheet Datasheet

Recommended HCST Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
Cat. No. ABIN7490759
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
Cat. No. ABIN3118830
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
Cat. No. ABIN3137344
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our HCST products

Fukasawa, Yoshizaki, Ebata, Yoshizaki-Ogawa, Asano, Enomoto, Miyagawa, Kazoe, Mawatari, Kitamori, Sato: "Single-cell-level protein analysis revealing the roles of autoantigen-reactive B lymphocytes in autoimmune disease and the murine model." in: eLife, Vol. 10, (2021) (PubMed).

Upshaw, Arneson, Schoon, Dick, Billadeau, Leibson: "NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells." in: Nature immunology, Vol. 7, Issue 5, pp. 524-32, (2006) (PubMed).

Synonyms and alternative names related to HCST

hematopoietic cell signal transducer (HCST), hematopoietic cell signal transducer (Hcst), hematopoietic cell signal transducer (hcst), hematopoietic cell signal transducer L homeolog (hcst.L), DAP10, Dap10, dap10, dap10-A, HCST, hcst, hcsta, KAP10, kap10, PIK3AP, pik3ap

Protein level used designations for HCST

  • DNAX-activation protein 10
  • kinase assoc pro of ~10kDa
  • kinase assoc protein
  • membrane protein DAP10
  • phosphoinositide-3-kinase adaptor protein
  • transmembrane adapter protein KAP10
  • immunoreceptor DAP10
  • hematopoietic cell signal transducer
  • putative membrane adaptor molecule
  • dap10
  • hematopoietic cell signal transducer A
  • hematopoietic cell signal transducer L homeolog
  • signal subunit, signaling transmembrane co-receptor
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