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Findings in the dorsolateral prefrontal cortex in schizophrenia provide evidence of altered proteins involved in synaptic function (FABP4 (show FABP4 Proteins)), cytoarchitecture organization (NEFH (show NEFH Proteins)), and circadian molecular clock signaling (CSNK1E), which may be contributing to the cognitive and/or negative symptoms in this disorder. FABP4 (show FABP4 Proteins), CSNK1E and NEFH (show NEFH Proteins) could become potentially useful biomarkers for schizophrenia.
low CK1epsilon expression is correlated with a low survival rate and CK1epsilon may play a role as a tumor suppressor in hepatocarcinogenesis.
Findings establish CK1varepsilon as a regulator of antiviral innate immune responses and indicate a novel mechanism of immunoregulation that involves CK1varepsilon-mediated phosphorylation of TRAF3 (show TRAF3 Proteins).
CSNK1E expression is associated with disease-free survival in breast cancer patients with wild-type p53 (show TP53 Proteins) or poor histological differentiation or in those without adjuvant chemotherapy.
a 4-locus CSNK1E haplotype encompassing the rs1534891 SNP (Z-score=2.685, permuted p=0.0076) and a 3-locus haplotype in ARNTL (show ARNTL Proteins) (Z-score=3.269, permuted p=0.0011) showed a significant association with Bipolar Disorder
site-specific phosphorylation of adiponectin, especially at sites targeted by CK1delta in vitro, provides an additional regulatory mechanism for modulating adiponectin complex formation and function.
The dynamical and conformational properties for each of three isoforms of CK1 (show CSNK1A1L Proteins) are explored through molecular dynamics (MD) simulations.
The results support our previous report of association of CSNK1E SNP rs1534891 with protection from heroin addiction. CSNK1E interacts with circadian rhythms and DARPP-32 (show PPP1R1B Proteins) and has been implicated in negative regulation of sensitivity to opioids in rodents.
CK1epsilon expression was higher in colorectal cancer tissues vs normal and was correlated with the Dukes staging and depth of invasion. Knockdown reduced cell proliferation and invasion and downregulated wnt3alpha, beta-catenin (show CTNNB1 Proteins), PCNA (show PCNA Proteins) and MMP-9 (show MMP9 Proteins).
Results indicate that changes in the expression levels of casein kinase 1 (show CSNK1A1 Proteins) isoforms CK1delta and DK1epsilon in colorectal tumors correlate with patients' survival.
Csnk1e deletion increased mu opioid receptor (show OPRM1 Proteins)-dependent behaviors.
Here, the authors identify another Wnt (show WNT2 Proteins) signaling amplifier, CKIepsilon, which is specifically upregulated in intestinal stem cells and is essential for intestinal stem cell maintenance, especially in the absence of its close isoform CKIdelta (show CSNK1D Proteins).
Linkage mapping, transcript covariance and pharmacological testing suggest that genetic variation affecting Csnk1e may contribute to individual differences in von Frey filament response.
mice bearing a short-period mutation in the enzyme casein kinase 1epsilon (tau mutation), which accelerates free-running circadian cycles, were investigated.
Data indicate period circadian proteins PER1 (show PER1 Proteins) and PER2 (show PER2 Proteins) as direct substrates of casein kinase 1epsilon (CK1epsilon).
Integrated genetic approaches identify the molecular mechanisms of Sox4 in early B-cell development: intricate roles for RAG1 (show RAG1 Proteins)/2 and CK1epsilon.
CK1 epsilon(tau), as a gain-of-function mutation, acts at a specific circadian phase to promote degradation of PERIOD proteins and thereby accelerate the mammalian clockwork in brain and periphery.
A narrow genetic locus containing Csnk1e is associated with differences in sensitivity to methamphetamine (MA) and fentanyl; variation at the Csnk1e locus can regulate the locomotor response to MA.
Identification of a novel Wnt5a-CK1varepsilon-Dvl2-Plk1-mediated primary cilia disassembly pathway.
Casein kinase 1epsilon activates minus-end-directed transport of membrane organelles along microtubules. CK1epsilon functions downstream of protein phosphatase PP2A in the pigment aggregation signaling pathway.
casein kinase I epsilon activity is regulated by Wnt (show WNT2 Proteins) signaling
results demonstrate that Bride of Doubletime (BDBT) interacts with doubletime(DBT (show DBT Proteins))in a manner requiring the DBT (show DBT Proteins) nuclear localization signal for nuclear localization and that the interaction is required to produce a fully functional circadian complex
we show that spag knock-down or reduced Dbt (show DBT Proteins) activity in circadian cells leads to longer circadian periods and expression of activated initiator caspase (show CASP3 Proteins) only during the middle of the day.
Responses of the clock to light via the regulated translation of DBT (show DBT Proteins).
Data show that the HSP-90 (show HSP90 Proteins) cochaperone spaghetti protein (SPAG) antagonizes casein kinase I epsilon DBT (show DBT Proteins) autophosphorylation in S2 cells
Data demonstrate that overall reduction of DBT (show DBT Proteins) causes long and arrhythmic behavior revealing an unexpected role in promoting synchrony of the circadian clock network.
kinetics of PER degradation with DBT (show DBT Proteins)(S) in cell culture resembles that with wild-type DBT (show DBT Proteins) and posits that, in flies DBT (show DBT Proteins)(S) likely does not modulate the clock by simply affecting PER degradation kinetics
The introduction of CKI-epsilon point mutation L39Q, found in human breast cancer, into the fly homolog dco causes an overgrowth phenotype in imaginal disc tissue. Adding S101R, modifies the mutant phenotype so that the affected tissue disintegrates.
expression of DBT in Drosophila S2 cells produced a CKI-7-sensitive kinase activity which was reduced by both the dbt(S) and dbt(L) mutations of circadian rhythm
doubletime and CKII (show CSNK2A1 Proteins) kinases collaborate to potentiate Drosophila PER transcriptional repressor activity
Dco coordinates tissue size by stimulating cell division/growth and blocking apoptosis via activation of DIAP1 (show DIAPH1 Proteins) expression.
The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene.
, casein kinase I isoform epsilon
, casein kinase 1 epsilon
, discs overgrown
, casein kinase I, epsilon
, CKI, epsilon
, KC1 epsilon
, casein kinase I epsilon
, casein kinase 1, epsilon
, casein kinase I isoform epsilon-like
, CG2048 gene product from transcript CG2048-RD
, Protein double-time
, casein kinase 1
, casein kinase iepsilon
, disc overgrown
, double time