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we demonstrate redistribution of intestinal MRP2 between plasma membrane and intracellular membrane in rat jejunum and in Caco-2 cells in response to db-cAMP and estradiol-17beta-D-glucuronide
The findings of the present study suggest that ABCC2 polymorphisms influence VPA concentrations in patients with epilepsy on VPA monotherapy.
Promoter ABCC2 -24C>T SNP affects both triglyceride levels and the TG/HDL-C ratio after short-term low-dose atorvastatin treatment in male but not female hypercholesterolaemic individuals.
genetic variability in the ABCC2 gene influences the in vitro expression, trafficking, and transport activity of MRP2
Polymorphisms of GSTP1 rs1695 and ABCC2 rs717620 can be used to predict the outcomes of Uygur patients with advanced NSCLC who have received platinum-based chemotherapy. Kaplan-Meier survival analysis indicated that survival with GSTP1 AG+ GG was significantly longer than in patients with AA gene (P<0.05), and survival with ABCC2 CT + TT was significantly longer than in patients with CC gene.
Results show that the response to treatment depended of the variability in genes engaged in drugs' transport ABCC2 c.-24C>T and ABCB1 p.Ser893Ala/Thr and in DNA repair machinery ERCC2 p.Lys751Gln.
Self-inhibition of the MRP2-dependent secretion of MTX is a plausible explanation for the time-dependent PKs of this drug.
SMS regulates the expression and function of drug transporters P-gp and MRP2.
genetic association studies in a population in France: Data that SNPs in ABCC2 are associated with regulation of secretion of endogenous organic anions; the 3 SNPs investigated (-24C>T, exon 1, rs717620; c.3972C>T, exon 28, rs3740066; c.1249G>A, exon 10, rs2273697) are associated with differential excretion of 35 of the 108 metabolites analyzed.
BCRP and MRP2 can mediate elimination of ochratoxin A from cells, reducing OTA toxicity.
Four SNPs within the APOE cluster (rs7412, rs4420638), ABCC2 (rs2002042) and CELSR/SORT1/PSRC1 (rs646776), displayed a major impact on statin efficacy. The wGRS was significantly associated with lower LDL-C at age 75 and 80
We analyzed 150 SNPs in eight key genes involved in vincristine pharmacokinetics and in 13 miRNAs that regulate them. We studied their correlation with neurotoxicity during induction phase in 152 ALL patients treated with LAL/SHOP protocols. The strongest associations with neurotoxicity were observed for two SNPs in ABCC2.
In the present review we focus on the role of MRP2 in the apical membrane of the enterocytes, as an important component of this intestinal barrier, as well as on its regulation and provide a detailed compilation of significant contributions demonstrating that MRP2 expression and function vary under relevant physiological and pathophysiological conditions
ABCC2 polymorphisms were associated with hematological toxicity in non-small cell lung cancer patients.
Meta-analysis. The ABCC2 c.-24C>T polymorphism increases the risk of resistance to antiepileptic drugs.
we have investigated the role of ABCB1 rs1045642 and rs2032582 and ABCC2 rs2273697 and rs717620 in antiepileptic drug-resistance. Our study suggests that the ABCC2 rs717620 polymorphism is associated with resistance to antiepileptic drugs in Chinese patients with epilepsy.
A novel deletion in ABCC2 gene was identified in families with dual hereditary jaundice.
Resveratrol-3-O-sulfate reduced in both MRP2-overexpressing MDCKII-UGT1A1 cells and Human UGT1A9-overexpressing HeLa cells.
A thalassemia patient has been found to be a carrier of UGT1A1 and ABCC2 polymorphisms explaining a possible reduction of desferasirox metabolism together with a reduction of biliary elimination by MRP2 and causing a serious adverse reaction.
ABCC2 expression in PBMCs may be, in part, influenced by gender, and that at least two endogenous control genes should be utilized.
The authors conclude that MRP1 assists in depression of polymorphonuclear cell (PMN) migration by effluxing a molecule that inhibits the proinflammatory effects of MRP2 activity.
Circadian oscillation of Mrp2 protein expression was clearly observed in the mouse liver with levels down at the light phase and up at the dark phase.
Biotinylation and streptavidin pull-down assays confirmed that CAL dramatically reduces the expression level of total and cell surface Mrp2 in Huh-7 cells. Our findings suggest that CAL interacts with Mrp2 and is a negative regulator of Mrp2 expression.
Deficiency in Mrp2 lowers platinum excretion and increases susceptibility to kidney injury, which can be rescued by the human MRP2 ortholog.
In Bcrp1;Mrp2;Mrp3(-/-), but not Bcrp1;Mdr1a/b;Mrp(-/-) mice.
Cd or H(2)O(2) exposure increased the expression of key transport genes, Mrp1 and Mrp2, in WT cells but not in metallothionein-null cells.
hepatic transporters Ntcp and Mrp2 are downregulated in rodent models of necrotizing enterocolitis
Both Abcc2 and Abcc3 significantly influenced the PK properties of MTX.
hyperosmotic cholestasis is triggered by a NADPH oxidase-driven reactive oxygen species formation that mediates Fyn-dependent retrieval of the Mrp2 and Bsep from the canalicular membrane, which may involve an increased cortactin phosphorylation.
Strain- and sex-dependent circadian patterns in abcc2 expressions displayed robust relations with the chronotolerance of ileum mucosa for irinotecan
In ABCC2-deficient mice impaired ABCC2 function is associated with a significant increase in erythromycin metabolism.
Membrane vesicles prepared from human erythrocytes, which express the MRP2 have important implications for the Selenium-dependent and -independent disposition of Arasenic.
NHERF-1 binds to Mrp2, and plays a critical role in the canalicular expression of Mrp2 and its function as a determinant of glutathione-dependent, bile acid-independent bile flow
Mrp2 mediates the adenosine triphosphate-dependent transport of N-acetyl-S-(1,2-dichlorovinyl)-l-cysteine but not S-(1,2-dichlorovinyl)-l-cysteine (DCVC) and may be involved in renal secretion of Ac-DCVC.
Data show that Abcc2, Abcc3, and Abcg2 together mediate the rapid elimination of MTX and 7OH-MTX.
Mrp2 transcription is down-regulated by Y-box protein 1.
mutation in the canalicular mdr2 is an important factor during the development of progressive familial cholestasis
nuclear factor, erythroid derived 2, like 2 appears to regulate Mrp2 gene expression via an antioxidant-response element element located at the proximal region of its promoter in response to exposure to xenobiotics
Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 are reviewed.
Mrp2 and Mrp3 provide alternative routes for the excretion of a glucuronidated substrate from the liver in vivo.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine\; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.
ATP-binding cassette sub-family C member 2
, canalicular multidrug resistance protein
, canalicular multispecific organic anion transporter 1
, multidrug resistance-associated protein 2
, multidrug resistance protein 2
, ATP-binding cassette, sub-family C (CFTR/MRP), member 2
, calicular multispecific organic anion transporter
, multidrug resistance associated protein 2