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Promoter ABCC2 -24C>T SNP affects both triglyceride levels and the TG/HDL (show HSD11B1 Proteins)-C ratio after short-term low-dose atorvastatin treatment in male but not female hypercholesterolaemic individuals.
genetic variability in the ABCC2 gene influences the in vitro expression, trafficking, and transport activity of MRP2
Polymorphisms of GSTP1 (show GSTP1 Proteins) rs1695 and ABCC2 rs717620 can be used to predict the outcomes of Uygur patients with advanced NSCLC who have received platinum-based chemotherapy. Kaplan-Meier survival analysis indicated that survival with GSTP1 (show GSTP1 Proteins) AG+ GG was significantly longer than in patients with AA gene (P<0.05), and survival with ABCC2 CT + TT was significantly longer than in patients with CC gene.
Results show that the response to treatment depended of the variability in genes engaged in drugs' transport ABCC2 c.-24C>T and ABCB1 (show ABCB1 Proteins) p.Ser893Ala/Thr (show TRH Proteins) and in DNA repair machinery ERCC2 (show ERCC2 Proteins) p.Lys751Gln.
Self-inhibition of the MRP2-dependent secretion of MTX (show MTX1 Proteins) is a plausible explanation for the time-dependent PKs of this drug.
SMS (show SMS Proteins) regulates the expression and function of drug transporters P-gp (show ABCB4 Proteins) and MRP2.
genetic association studies in a population in France: Data that SNPs in ABCC2 are associated with regulation of secretion of endogenous organic anions; the 3 SNPs investigated (-24C>T, exon 1, rs717620; c.3972C>T, exon 28, rs3740066; c.1249G>A, exon 10, rs2273697) are associated with differential excretion of 35 of the 108 metabolites analyzed.
BCRP and MRP2 can mediate elimination of ochratoxin A from cells, reducing OTA toxicity.
Four SNPs within the APOE (show APOE Proteins) cluster (rs7412, rs4420638), ABCC2 (rs2002042) and CELSR/SORT1 (show SORT1 Proteins)/PSRC1 (show PSRC1 Proteins) (rs646776), displayed a major impact on statin efficacy. The wGRS was significantly associated with lower LDL-C at age 75 and 80
We analyzed 150 SNPs in eight key genes involved in vincristine pharmacokinetics and in 13 miRNAs that regulate them. We studied their correlation with neurotoxicity during induction phase in 152 ALL patients treated with LAL (show LIPA Proteins)/SHOP protocols. The strongest associations with neurotoxicity were observed for two SNPs in ABCC2.
The authors conclude that MRP1 (show ABCC1 Proteins) assists in depression of polymorphonuclear cell (PMN (show TBCE Proteins)) migration by effluxing a molecule that inhibits the proinflammatory effects of MRP2 activity.
Circadian oscillation of Mrp2 protein expression was clearly observed in the mouse liver with levels down at the light phase and up at the dark phase.
Biotinylation and streptavidin pull-down assays confirmed that CAL (show S100A11 Proteins) dramatically reduces the expression level of total and cell surface Mrp2 in Huh-7 cells. Our findings suggest that CAL (show S100A11 Proteins) interacts with Mrp2 and is a negative regulator of Mrp2 expression.
Deficiency in Mrp2 lowers platinum excretion and increases susceptibility to kidney injury, which can be rescued by the human MRP2 ortholog.
In Bcrp1;Mrp2;Mrp3(-/-), but not Bcrp1;Mdr1a/b;Mrp(-/-) mice.
Cd or H(2)O(2) exposure increased the expression of key transport genes, Mrp1 (show ABCC1 Proteins) and Mrp2, in WT cells but not in metallothionein (show MT Proteins)-null cells.
hepatic transporters Ntcp (show SLC10A1 Proteins) and Mrp2 are downregulated in rodent models of necrotizing enterocolitis
Both Abcc2 and Abcc3 (show ABCC3 Proteins) significantly influenced the PK properties of MTX (show MTX1 Proteins).
hyperosmotic cholestasis is triggered by a NADPH oxidase (show NOX1 Proteins)-driven reactive oxygen species formation that mediates Fyn (show FYN Proteins)-dependent retrieval of the Mrp2 and Bsep (show ABCB11 Proteins) from the canalicular membrane, which may involve an increased cortactin (show CTTN Proteins) phosphorylation.
Strain- and sex-dependent circadian patterns in abcc2 expressions displayed robust relations with the chronotolerance of ileum mucosa for irinotecan
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine\; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.
ATP-binding cassette sub-family C member 2
, canalicular multidrug resistance protein
, canalicular multispecific organic anion transporter 1
, multidrug resistance-associated protein 2
, multidrug resistance protein 2
, ATP-binding cassette, sub-family C (CFTR/MRP), member 2
, calicular multispecific organic anion transporter
, multidrug resistance associated protein 2