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Cytosolic localization of NADH cytochrome b oxidoreductase
data provide first evidence for natural mutations in NCB5OR gene resulting in decreased protein levels and hence having potential implications in human pathology.
Mutation in cytochrome b5 reductase is associated with developmental delay and severe neurological problems.
Study of the individual cytochrome b5 and cytochrome b5 reductase domains of Ncb5or reveals a unique heme pocket and a possible role of the CS domain.
NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum
Variaation in the coding region is not a major contributor in the pathogenesis of nonautoimmune diabetes.
Our findings suggest an essential role for NCB5OR in maintaining both iron homeostasis and the proper functioning of various locomotor pathways in the mouse cerebellum and midbrain.
In livers of HRN mice Cyp1a1, cytochrome b5 and mEH can effectively activate BaP to DNA binding species, even in the presence of very low amounts of P450 oxidoreductase.
FFA accumulation and catabolism and oxidative stress are major consequences of Ncb5or deficiency in liver.
Onset of hyperglycemia in the Chop(-/-);Ncb5or(-/-) mice was delayed two weeks beyond that observed in Chop(+/+);Ncb5or(-/-) mice.
Data suggest that NCB5OR appears to play a critical role in protecting pancreatic beta cells against oxidant stress.
The data presented here identify and characterize the previously unknown promoter of Ncb5or, a reductase critical for beta-cell survival.
Data suggest that NCB5OR does not appear to be involved in ER stress, although it may be involved in maintaining or regulating the redox status in beta-cells.
Ncb5or loss results in impaired fatty acid desaturation, lipoatrophy, and diabetes
NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5A\; MIM 613218) and CYB5 reductase (CYB5R3\; MIM 613213) (Zhu et al., 1999
cytochrome b5 reductase 4
, N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein
, NADPH cytochrome B5 oxidoreductase
, cytochrome b-type NAD(P)H oxidoreductase
, flavohemoprotein b5+b5R
, flavohemoprotein b5/b5R