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Galanin, acting via the GAL1 (show LGALS1 Proteins) receptor and Gi -coupled signalling in L and K cells, is a potent inhibitor of GLP-1 (show GCG Proteins) and GIP (show GIP Proteins) secretion
Galanin released by cancer induces neuritogenesis, facilitating perineural invasion.
Study shows that LIF (show LIF Proteins)-treated postmitotic oligodendrocytes secrete a number of neuropeptides, in particular galanin, at the mRNA and peptide level, and galanin itself was shown to be a survival factor for oligodendrocytes
Results suggest that GAL is a regulator of myelination, as demonstrated by MBP (show MBP Proteins) synthesis, and may be one of the myelination promoters
Oleuropein protects mice from gh-fat diet induced adiposity by upregulation of genes involved in WNT10b (show WNT10B Proteins)-mediated signaling and downregulation of genes involved in galanin-mediated signaling cascades.
medial preoptic area galanin neurons emerge as an essential regulatory node of male and female parenting behaviour and other social responses
Analysis of the gene proximal region using EMSA and ChIP assays showed that CREB (show CREB1 Proteins) protein interacts with the galanin promoter both in vitro and in vivo. Additional EMSA analysis revealed that an SP1 (show SP1 Proteins) consensus site mediated protein-DNA complex formation.
The expression of mRNA galanin is increased following chronic restraint stress.
These results suggest that sertraline-related galanin induction in ventral dentate gyrus may play an important role in therapeutic mechanisms for depression.
extended perifornical area galanin-LepRb (show LEPR Proteins) neurons galanin acts inhibitory rather than orexigenic
Data show that PKA and PKC pathways are involved in the differential regulation of production of the neuropeptides (Met)enkephalin, galanin, somatostatin (show SST Proteins), NPY (show NPY Proteins), and VIP (show Vip Proteins).
Higher serum galanin levels were determined in patients with impaired glucose tolerance.
Serum galanin (GAL) levels are significantly higher in the obese group compared with lean subjects during an oral glucose tolerance test (OGTT).
Galanin per se did not affect the dynamic mass redistribution of natural killer (NK) cells, but significantly enhanced the response of NK cells to IL-18 (show IL18 Proteins)
majority of intrinsic choroidal neurons were GAL-positive
ultraviolet irradiation upregulated galanin mRNA and protein expression in keratinocytes in vitro and in human skin in vivo
GAL and its receptor GALR3 are differentially methylated and expressed in brains of major depressive disorder subjects in a region- and sex-specific manner.
Study found dramatic reduction in von Willebrand factor (show VWF Proteins) extrusion and multimer expression by the neuropeptide galanin in cultured endocardial endothelial cells from heart failure patients. Results suggest that a combination of beta-blockers and galanin therapy may be one therapeutic option for improving endocardial endothelial anticoagulant function.
The analyses revealed that the presence of the galanin gene minor allele (G) increased susceptibility to multiple sclerosis in men (OR = 2.49, P = 0.008) but not in women.
Study provides evidence that GAL and GALR1/2 genes were identified as aberrantly methylated in head and neck squamous cell carcinoma.
Our results identified FGL2 (show FGL2 Proteins), GAL, SEMA4D (show SEMA4D Proteins), SEMA7A (show SEMA7A Proteins), and IDO1 (show IDO1 Proteins) as new candidate genes that could be involved in MSCs-mediated immunomodulation. FGL2 (show FGL2 Proteins), GAL, SEMA4D (show SEMA4D Proteins), SEMA7A (show SEMA7A Proteins), and IDO1 (show IDO1 Proteins) genes appeared to be differentially transcribed in the different MSC (show MSC Proteins) populations. Moreover, these genes were not similarly modulated following MSCs-exposure to inflammatory signals
Real-Time PCR revealed the increased expression of mRNA encoding Gal and GalR1 receptor in the pyloric wall tissue of the experimental animals, while the expression(s) of GalR2 and GalR3 were not significantly changed.
Localization of galanin, in the nerve fibers of porcine cystic ovaries
Galanin is small neuropeptide that functions as a cellular messenger within the central and peripheral nervous systems, modulating diverse physiologic functions (Mechenthaler, 2008
galanin prepropeptide, gene 2
, galanin peptides
, galanin prepropeptide
, galanin-message-associated peptide
, galanin-related peptide