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PP2B-Aalpha-Munc18c complex supports agonist-induced VWF (show VWF Proteins) secretion by HUVECs.
Data suggest MUNC18C is required for STX4 (show STX4 Proteins)-mediated invadopodium formation and tumor invasion of extracellular matrix; N-terminal STX4 (show STX4 Proteins) fragment binds to MUNC18C and inhibits interactions of STX4 (show STX4 Proteins) with synaptosome-associated protein 23 (SNAP23 (show SNAP23 Proteins)) and vesicle-associated membrane protein 2 (VAMP2 (show VAMP2 Proteins)). Fibrosarcoma/adenocarcinoma cell lines were used in these studies. (MUNC18C = syntaxin binding protein MUNC18C; STX4 (show STX4 Proteins) = syntaxin 4 (show STX4 Proteins))
In vitro interaction assays indicated that Doc2b (show DOC2B Proteins) is required to bridge the interaction between Munc18c and Munc18-1 (show STXBP1 Proteins) in the macromolecular complex; Munc18c and Munc18-1 (show STXBP1 Proteins) failed to associate in the absence of Doc2b (show DOC2B Proteins)
Munc18c gene expression in human adipose tissue is down-regulated in morbid obesity.
Western Blot data showed decreased expression (p < 0,05) of Munc18c and phospho-PKC Zeta (show PRKCZ Proteins) in polycystic ovary-insulin (show INS Proteins) resistant endometria (PCOSE-IR) with respect to the control.
The identify IR as the first known tyrosine kinase for Munc18c as part of a new insulin-signaling step in GLUT4 vesicle exocyto (show INS Proteins)sis.
Calpha (show PRKACA Proteins) activation and phosphorylation of syntaxin 4 (show STX4 Proteins) and Munc18c are required for the cell surface expression of P-selectin (show SELP Proteins) and the consequent binding of neutrophils to endothelial cells.
Munc18-2 (show STXBP2 Proteins) acts as a regulator of primary granule exocytosis, while Munc18-3 may preferentially regulate the fusion of secondary granules
These results indicate that insulin (show INS Proteins) induces dynamic associations between PKCzeta (show PRKCZ Proteins), 80K-H (show PRKCSH Proteins), and munc18c and that 80K-H (show PRKCSH Proteins) may act as a key signaling link between PKCzeta (show PRKCZ Proteins) and munc18c in live cells.
Investigated the use of Escherichia coli as an expression host for Munc18c. Three N-terminal His-tagged constructs were engineered, two with a tobacco etch virus (TEV) or thrombin (show F2 Proteins) protease cleavage site to enable removal of the fusion tag.
PTP1B (show PTPN1 Proteins) is the first known tyrosine phosphatase for Munc18c and a regulator of its phosphorylation and function in adipocytes.
Ectopic expression of syntaxin3 affects behaviors of B16 melanoma by controlling actin dynamics.
Munc18c provides stimulus-specific regulation of GLUT4 (show SLC2A4 Proteins) trafficking, but not FA transporter trafficking
The Using 3T3-L1 adipocytes subjected to small interfering ribonucleic acid reduction of Munc18c as a model of impaired insulin (show INS Proteins)-stimulated GLUT4 (show SLC2A4 Proteins) vesicle exocytosis.
Cellular munc18c levels can modulate glucose transport rate and GLUT4 (show SLC2A4 Proteins) translocation in 3T3L1 cells.
our data suggest that the mechanism by which glucosamine inhibits insulin (show INS Proteins)-stimulated GLUT4 (show SLC2A4 Proteins) translocation involves modification of Munc18c.
balance, more than absolute abundance, of Munc18c and Syn4 (show STX4 Proteins) proteins directly affects whole-body glucose homeostasis through alterations in insulin (show INS Proteins) secretion and insulin (show INS Proteins) action.
To define the molecular machinery required for platelet exocytosis, platelets from Munc18c heterozygous knockout mice were analyzed. These platelets show a decrease in Munc18c but no apparent reduction in other secretory machinery components
The interaction between syntaxin4 (show STX4 Proteins) and Munc18c in adipocytes results in enhancement of insulin (show INS Proteins)-stimulated GLUT4 (show SLC2A4 Proteins) externalization.
Might act as an inhibitor of spontaneous calcium carbonate precipitation.
platelet Sec1 protein
, protein unc-18 homolog 3
, protein unc-18 homolog C
, syntaxin 4 binding protein
, syntaxin-binding protein 3
, syntaxin binding protein 3
, syntaxin-binding protein 3-like
, mammalian homolog of Unc-18c
, unc-18 homolog 3