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anti-Human HEYL Antibodies:
anti-Mouse (Murine) HEYL Antibodies:
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Human Monoclonal HEYL Primary Antibody for IF, ELISA - ABIN525730
Kuo, Jian, Li, Wan, Weng, Fang, Wu, Cheng: Epigenetic inactivation of transforming growth factor-?1 target gene HEYL, a novel tumor suppressor, is involved in the P53-induced apoptotic pathway in hepatocellular carcinoma. in Hepatology research : the official journal of the Japan Society of Hepatology 2014
Human Monoclonal HEYL Primary Antibody for IF, IHC (p) - ABIN525732
Lavery, Villaronga, Walker, Patel, Belandia, Bevan: Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectors. in The Journal of biological chemistry 2011
Human Monoclonal HEYL Primary Antibody for IF, ELISA - ABIN525731
Gomi, Arbelaez, Crystal, Walters: Activation of NOTCH1 or NOTCH3 signaling skews human airway basal cell differentiation toward a secretory pathway. in PLoS ONE 2015
Cow (Bovine) Polyclonal HEYL Primary Antibody for WB - ABIN2777466
Nakagawa, McFadden, Nakagawa, Yanagisawa, Hu, Srivastava, Olson: Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. in Proceedings of the National Academy of Sciences of the United States of America 2000
Show all 2 Pubmed References
HEYL rs784621 AA genotype is associated with poor response to therapy in Non-small Cell Lung Cancer.
LSD1 (show KDM1A Antibodies) directly associates with the promoter of the HEYL gene.
repression of TGFbeta (show TGFB1 Antibodies) signaling by Notch (show NOTCH1 Antibodies) acting through HEYL may promote initiation of breast cancer
Repression of androgen receptor (show AR Antibodies) activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch (show NOTCH1 Antibodies) effectors.
In this study, we analyzed the effects of HESR1 (show HEY1 Antibodies), -2, and -3 on DAT1 expression in human neuroblastoma (show ARHGEF16 Antibodies) SH-SY5Y cells
HeyL null mice do not exhibit an obvious skeletal phenotype demonstrating that HeyL is dispensable for skeletal homeostasis.
These results indicate that Hesr1 (show HEY1 Antibodies) and Hesr3 are essential for the generation of adult satellite cells and for the maintenance of skeletal muscle homeostasis.
This study demonistrated that HeyL promotes neuronal differentiation of neural progenitor cells by activating proneural genes and by inhibiting the actions of other Hes (show ATCAY Antibodies) and Hey family members.
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.
, class B basic helix-loop-helix protein 33
, hairy-related transcription factor 3
, hairy/enhancer-of-split related with YRPW motif 3
, hairy/enhancer-of-split related with YRPW motif-like protein
, hairy and enhance of split related 3
, hairy and enhancer of split-related protein 3
, basic helix-loop-helix transcription factor heyL