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Imp13 forms a ring-like molecule encircling the Mago (show MAGOH Proteins)-Y14 (show RBM8A Proteins) cargo with a conserved interaction surface.
Imp13 is a novel factor that affects neurotransmitter release at the fly neuromuscular junction.
IPO13 influenced intracellular distribution of CTCF (show CTCF Proteins).
IPO13 may contribute to the pathogenesis of pterygium via modulation of K17 (show KRT17 Proteins) and c-Jun (show JUN Proteins).
Imp13 is able to bind and export eIF1A (show EIF1AX Proteins) in vivo and that its function is essential.
These results demonstrate an increased expression of IPO13 in endometriosis and endometrial carcinoma.
Data show that expression of IPO13, c-kit, telomerase, caspase3, and CD146 (show MCAM Proteins) are decreased in endometrial polyps; however, the expression of bcl-2 (show BCL2 Proteins) was increased in polyps compared to the normal endometrial tissue.
IPO13 is uniquely expressed by human limbal basal epithelial cells, and plays an important role in maintaining the phenotype, high proliferative potential, and less differentiation of corneal epithelial progenitor cells.
Imp13 functions in myopodin (show SYNPO2 Proteins) import and the regulation of this event is critical for normal and abnormal cellular differentiation.
Importin 13 mediates nuclear import of histone fold-containing chromatin accessibility complex heterodimers
IPO13 variation may improve nuclear bioavailability of endogenous glucocorticoids
Interactome of the inhibitory isoform of the nuclear transporter (show RPAIN Proteins) Importin 13 has been reported.
Imp13 contributes to the neural cell-specific cargo trafficking and potentially to other functions during brain development.
IPO13 has a stage-specific role in nuclear-cytoplasmic translocation of cargoes that accompanies meiotic differentiation of the mouse germ cells
This gene encodes a member of the importin-beta family of nuclear transport proteins. The encoded protein mediates the import of specific cargo proteins from the cytoplasm to the nucleus and is dependent on the Ras-related nuclear protein-GTPase system. The encoded protein is also involved in nuclear export of the eukaryotic translation initiation factor 1A.
, complementation group 5
, importin 13
, Ran binding protein 13
, karyopherin 13
, late gestation lung 2
, ran-binding protein 13
, late gestation lung 2 protein