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Our findings directly associate the AR/NCOA1 complex with PRKD1 (show PRKD1 Proteins) regulation and cellular migration and support the concept of therapeutic inhibition of NCOA1 in prostate cancer.
SRC-1 (show SRC Proteins) can impact osteoblast function in an estrogen receptor (show ESR1 Proteins)-independent manner.
The pregnane X receptor (show NR1I2 Proteins) down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 (show SRC Proteins) coactivator.
miR (show MLXIP Proteins)-4443 acts in a tumor-suppressive manner by down-regulating TRAF4 (show TRAF4 Proteins) and NCOA1 downstream of MEK (show MAP2K1 Proteins)-C/EBP (show CEBPA Proteins)-mediated leptin (show LEP Proteins) and insulin (show INS Proteins) signaling, and that insulin (show INS Proteins) and/or leptin (show LEP Proteins) resistance (e.g. in obesity) may suppress this pathway and increase the risk of metastatic CRC (show CALR Proteins).
Results provide the first evidence that NCOA1 is a direct target of miR (show MLXIP Proteins)-105-1 suggesting that NCOA1 and miR (show MLXIP Proteins)-105-1 may have potential prognostic value and may be useful as tumor biomarkers for the diagnosis of HCC (show FAM126A Proteins) patients.
Data suggest that steroid receptor (show ESR2 Proteins) coactivators (NCOA1, NCOA2 (show NCOA2 Proteins), NCOA3 (show NCOA3 Proteins)) are over-expressed in a number of hormone-dependent cancers where they promote tumor growth, invasion, metastasis, and chemo-resistance; with their multiple roles in cancer, steroid receptor (show ESR2 Proteins) coactivators are promising targets for development of antineoplastic agents that can interfere with their function. [REVIEW]
The mechanism of IL-6-induced AR activation is mediated through enhancing AR-SRC-1 interaction and inhibiting AR-SMRT interaction.
IL-6-mediated AR antagonism induced by cypermethrin is related to repress the recruitment of co-regulators SRC-1 and SMRT to the AR in a ligand-independent manner
NCOA1 potentiates breast cancer angiogenesis through upregulating HIF1alpha (show HIF1A Proteins) and AP-1 (show FOSB Proteins)-mediated VEGFa (show VEGFA Proteins) expression
miR (show MLXIP Proteins)-137 has a role in targeting p160 (show MSH6 Proteins) steroid receptor (show ESR2 Proteins) coactivators SRC1 (show SRC Proteins), SRC2 (show NCOA2 Proteins), and SRC3 (show NCOA3 Proteins) and inhibits cell proliferation
Although the SRC-1 expression in female mice was lower than that in males under normal conditions, its expression in females was more dominant after spinal cord injury. The expression of Profilin-1 (show PFN1 Proteins) in both sexes increased first, and then decreased at 3 days after injury. However, there was a second increase in females at 7 days after injury.
SRC-1 can impact osteoblast function in an estrogen receptor (show ESR1 Proteins)-independent manner.
The results suggest that biochanin A activates RORgamma-dependent IL-17 (show IL17A Proteins) transcription through the enhancement of STAT3 (show STAT3 Proteins) phosphorylation and STAT3 (show STAT3 Proteins)-mediated recruitment of NCOA1 to RORgamma.
ubiquitination of K446 limits RORgammat-mediated Th17 differentiation by inhibiting the recruitment of coactivator SRC1
Loss of SRC-1 is associated with high Blood Pressure and Aortic Stiffness.
local E2 inhibition could induce aberrant actin polymerization and also showed an important role of SRC-1 in the mediation of local E2 action on hippocampal synaptic plasticity by regulation of actin cytoskeleton dynamics
SRC-1/3 are required for cardiomyocyte proliferation and differentiation at earlier developmental stages, and their dysfunction causes NCC (show SLC12A3 Proteins)-like abnormalities in the hearts of newborn and adult mice.
While hippocampal SRC-1 was significantly downregulated by orchidectomy (ORX), its expression was rescued by treatment with testosterone in a dose-dependent manner. Testosterone regulates synaptic proteins involves AR, estrogen receptors and SRC-1.
fetal lungs produce signals to initiate labor when mature, and SRC-1/-2-dependent production of SP-A (show SFTPA1 Proteins) and PAF (show PAF Proteins) is crucial for this process
Consequently, SRC-1 null mice displayed low TAT (show TAT Proteins) expression and presented with hypertyrosinemia and corneal alterations, 2 clinical features observed in the human syndrome of TAT (show TAT Proteins) deficiency.
we cloned and sequenced full length cDNA of NCOA-1 gene in pig. The putative protein includes 1440 amino acids. Sequences alignment showed that pig NCOA-1 gene cDNA sequence has identity of 93.73% with human and mouse.
The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified.
, PAX3/NCOA1 fusion protein
, class E basic helix-loop-helix protein 74
, renal carcinoma antigen NY-REN-52
, steroid receptor coactivator-1
, nuclear receptor coactivator 1
, steroid receptor coactivator 1
, nuclear receptor coactivator protein 1