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Cow (Bovine) Polyclonal RBM14 Primary Antibody for WB - ABIN2778973
Sui, Yang, Xiong, Zhang, Blanchard, Peiper, Dynan, Tuan, Ko: Gene amplification and associated loss of 5' regulatory sequences of CoAA in human cancers. in Oncogene 2007
RBM14 plays crucial role in regulation of non-homologous end joining upon DNA damage.
RBM14 connects key paraspeckle subcomplexes via interactions mediated by its prion (show PRNP Antibodies)-like domain.
This study identifies a cellular protein named RBM14 that is associated with XPO1 (CRM1 (show XPO1 Antibodies)), a nuclear protein (show RDBP Antibodies) that binds to the HIV-1 Rev protein and mediates nuclear export of incompletely spliced HIV-1 viral RNAs
upon RBM14 depletion, a part of the ectopic centriolar protein complexes in turn assemble into structures more akin to centrioles, presumably by incorporating HsSAS-6 (show SASS6 Antibodies), a cartwheel component, and cause multipolar spindle formation.
RBM14 promotes radio-resistance in glioblastoma by regulating DNA repair and cell differentiation.
CoAA is involved in the migration-enhancing action of PEA3 (show ETV4 Antibodies) on MCF7 metastatic human cancer cells.
SYT (show SS18 Antibodies) interacts with SYT-interacting protein/co-activator activator
The CoAA gene is amplified in human cancers
CoAA is a potential tumor suppressor in renal carcinoma (show TSC2 Antibodies) and CoAM is a counterbalancing splice isoform.
The alternative splicing imbalance of CoAA and RBM4 (show RBM4 Antibodies), because of loss of their common enhancer in cancer, may deregulate stem/progenitor cell differentiation
This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene.
RNA binding motif protein 14
, RNA-binding protein 14
, RRM-containing coactivator activator/modulator
, SYT-interacting protein
, paraspeckle protein 2
, synaptotagmin-interacting protein
, transmembrane protein 137
, RNA-binding motif protein 14
, synaptotagmin interacting protein
, coactivator activator