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anti-Human RNF4 Antibodies:
anti-Mouse (Murine) RNF4 Antibodies:
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Human Polyclonal RNF4 Primary Antibody for WB - ABIN1537658
Wang, Sang, Ren, Liu, Liu, Zhang, Wang, Wang, Orian, Yang, Yi: SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation. in Protein & cell 2015
RNF4-dependent ubiquitylation translates transient phosphorylation signal(s) into long-term protein stabilization, resulting in enhanced oncoprotein activation
These findings indicate that SUMOylation of NDRG2 (show NDRG2 Antibodies) is necessary for its tumor suppressor function in lung adenocarcinoma and that RNF4 increases the efficiency of this process.
post-translational modification of Nkx3.2 (show NKX3-2 Antibodies) employing HDAC9 (show HDAC9 Antibodies)-PIASy (show PIAS4 Antibodies)-RNF4 axis plays a crucial role in controlling chondrocyte viability and hypertrophic maturation during skeletal development in vertebrates.
These findings illustrate a novel strategy for viral interference with the SUMO pathway, and identify the EBV miR (show MLXIP Antibodies)-BHRF1-1 and the cellular RNF4 as regulators of the productive virus cycle.
These results point to an important role of the affinity between RNF4 and its cognate RAD6B (show UBE2B Antibodies) or UBCH5B (show UBE2D2 Antibodies) in governing the multiplicity of substrate ubiquitination.
the opposing activities of RNF4 and ataxin-3 (show ATXN3 Antibodies) consolidate robust MDC1 (show MDC1 Antibodies)-dependent signaling and repair ofDNA double-strand break.
Combined effect of dynamic recruitment of RNF4 to KAP1 regulates the relative occupancy of 53BP1 and BRCA1 at double-strand break sites to direct DNA repair in a cell cycle-dependent manner.
c-Myc (show MYC Antibodies) is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1 (show PIAS1 Antibodies), SENP7 (show SENP7 Antibodies) and RNF4
Data show that RNF4 is a SUMO-targeted ubiquitin ligase that targets TRF2 (show TERF2 Antibodies) for ubiquitination.
novel insight into cross-talk between ubiquitin and SUMO and uncover USP11 (show USP11 Antibodies) and RNF4 as a balanced SUMO-targeted ubiquitin ligase/protease pair with a role in the DDR (show DDR1 Antibodies).
These findings suggest that the UBC9/PML/RNF4 axis plays a critical role as an important SUMO pathway in cardiac fibrosis. Modulating the protein levels of the pathway provides an attractive therapeutic target for the treatment of cardiac fibrosis and heart failure.
This paper identifies a nucleosome-targeting motif within the RNF4 RING domain that can bind DNA and thereby enables RNF4 to selectively ubiquitinate nucleosomal histones.
fork collapse in Atr (show ATR Antibodies)-deleted cells is mediated through the combined effects the sumo targeted E3-ubiquitin ligase RNF4 and activation of the AURKA (show AURKA Antibodies)-PLK1 (show PLK1 Antibodies) pathway
Rnf4 controls protein localization at DNA damage sites by integrating SUMOylation and ubiquitylation events.
SUMO interacting motif is dispensable for PML (show PML Antibodies) SUMOylation and interaction with RNF4 but is required for efficient PML (show PML Antibodies) ubiquitination, recruitment of proteasome components within NBs (show NLRP2 Antibodies) and proteasome-dependent degradation of PML (show PML Antibodies) in response to AsO
Rnf4 deficiency is embryonic lethal with higher levels of methylation in genomic DNA. Mechanistic studies show that RNF4 interacts with and requires the base excision repair enzymes TDG (show TDG Antibodies) and APE1 (show APEX1 Antibodies) for active demethylation.
GC-rich (show RELB Antibodies) elements flanking the transcription start site govern activation
1.6- and 3.0-kb transcripts originate from the same promoter, encode for the same protein and differ in the 3' UTR (show UTS2R Antibodies).
RNF4 is a negative regulator of TRPS1 (show TRPS1 Antibodies) activity
results suggest a role for small nuclear ring finger protein(SNURF/RNF4) in fetal germ cell development as well as in oocyte and granulosa cell maturation in an estrogen- and gonadotropin-regulated fashion
The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.
E3 ubiquitin ligase RNF4
, E3 ubiquitin-protein ligase RNF4
, small nuclear RING finger protein
, gene trap ROSA b-geo 8
, small nuclear ring finger protein
, RING finger protein 4