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up-regulates GRP78 in the placenta
The identification of the miR (show MLXIP Proteins)-206/TWF1 (show TWF1 Proteins)/MKL1-SRF/IL11 signaling pathway sheds lights on the understanding of breast cancer initiation and progression, unveils new therapeutic targets, and facilitates innovative drug development to control cancer and block metastasis
Results indicate that hypoxia increases IL-11 secretion in anaplastic thyroid carcinoma (ATC) cells via HIF-1alpha induction and that IL-11 then induces epithelial-mesenchymal transition (EMT) in these cells via the PI3K/Akt/GSK3beta pathway.
In this review, we describe the basic biology of both cytokines and summarize the current knowledge how proteases control and shape the trans-signaling pathways of the two cytokines.We will further highlight how the underlying molecular mechanisms can be used to design specific inhibitors that block trans, but not classic signaling of IL-11 and IL-6 (show IL6 Proteins)
This review will discuss the available structural, functional, and bioinformatics knowledge concerning IL-11 and will summarize its relationship with several diseases
Authors found a significant correlation between NRF2 (show GABPA Proteins) and IL-11 status in breast cancer patients. Based on a recent report demonstrating that IL-11 is induced downstream of NRF2 (show GABPA Proteins), authors examined the significance of IL-11 in NRF2 (show GABPA Proteins)-driven tumorigenesis with a newly established NRF2 (show GABPA Proteins) addiction cancer model.
this study shows that recombinant IL-11 is effective with tolerable adverse effects in Chinese patients with autoimmune thrombocytopenic purpura
HMGA2 promoted colorectal cancer metastasis and epithelial-mesenchymal transition via activation of the FN1 (show FN1 Proteins) and IL11/STAT3 (show STAT3 Proteins) signaling pathways.
Together, these results suggest that the IL-11/STAT3 (show STAT3 Proteins) signaling pathway plays a critical role in human chronic atrophic gastritis , and may provide new targets to prevent and treat gastric cancer
Proteolysis of the IL-11R represents a molecular switch that controls the IL-11 trans-signaling pathway which is the target in intestinal tumorigenesis, lung carcinomas, and asthma.
activates PDIA4 in placenta
these findings suggest that classic signalling rather than trans-signalling is the mode by which IL-11 promotes gastric tumourigenesis.
Results indicate that iterleukin-11 (IL11) is causal of Preeclampsia (PE) features in a mouse model and likely in women, and suggest potential of IL11 inhibition to rescue PE symptoms in women.
IL-11-mediated STAT3 (show STAT3 Proteins) signaling not only reduces hepatocellular apoptosis, but also inhibits inflammatory responses.
IL-1 (show IL1A Proteins) signaling antagonizes IL-11/STAT3 (show STAT3 Proteins) mediated pathology and the genetic deletion of IL-1RT1 results in increased tumor burden.
PGF2alpha inhibits adipocyte differentiation by means of an IL-11 mediated autocrine negative feedback loop, that acts via gp130 (show LRPPRC Proteins) to block adipogenesis through the essential actions of the STAT1 (show STAT1 Proteins) transcription factor.
Data indicate that colonic inflammation was more severe in mice fed an iron-supplemented compared with a control diet one week post-DSS (show PMP22 Proteins) treatment, with enhanced colonic IL-6 (show IL6 Proteins) and IL-11 release and Stat3 (show STAT3 Proteins) phosphorylation.
IL-11 reduced the production of reactive oxygen species.
IL-11 therefore drives a pathway that enhances HSPC (show PSMA7 Proteins) radioresistance and radiation-induced B-cell malignancies, but is normally attenuated by the inhibitory adaptor Lnk (show SH2B3 Proteins).
IL-11 signaling may not play as significant a role in spinal cord injury as other glycoprotein gp130 cytokines.
The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
, adipogenesis inhibitory factor