anti-Mouse (Murine) IL2 Receptor beta antibody for Functional Studies

Recommended IL2 Receptor beta Antibody (supplied by: Log in to see )

Antigen
Interleukin 2 Receptor, beta (IL2RB) Antibodies
  • IL2RB
  • il-2rb
  • CD122
  • IL15RB
  • P70-75
  • IL2RBC
  • IL-15Rbeta
  • IL15Rbeta
  • Il-2/15Rbeta
  • Il-2Rbeta
  • p70
  • interleukin 2 receptor subunit beta
  • interleukin-2 receptor subunit beta
  • interleukin 2 receptor, beta
  • interleukin 2 receptor, beta chain
  • IL2RB
  • LOC510185
  • il2rb
  • Il2rb
Reactivity
Mouse (Murine)
216
171
92
29
6
1
1
Host
Rat
135
129
89
Clonality
Monoclonal
Conjugate
This IL2 Receptor beta antibody is un-conjugated
33
31
22
14
9
8
6
6
6
6
6
5
4
4
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
Application
Functional Studies (Func), Flow Cytometry (FACS), Immunoprecipitation (IP)
218
108
58
51
34
26
15
11
9
7
6
5
4
3
3
2
1
1
1
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Catalog No. ABIN120200
$ 687.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2478329 Func FACS IP Rat IgG2b Log in to see TM-BETA 1 3
1 ABIN594132 Func FACS IP Rat IgG2b Log in to see 0
1 ABIN217736 Func FACS IP Rat IgG2b Log in to see 0
1 ABIN642454 Func FACS IP Rat Log in to see 0

General

Antigen Interleukin 2 Receptor, beta (IL2RB) Antibodies
Reactivity Mouse (Murine)
(216), (171), (92), (29), (6), (1), (1)
Host Rat
(135), (129), (89)
Clonality (Clone)
Monoclonal   ( )
Conjugate This IL2 Receptor beta antibody is un-conjugated
(33), (31), (22), (14), (9), (8), (6), (6), (6), (6), (6), (5), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Application Functional Studies (Func), Flow Cytometry (FACS), Immunoprecipitation (IP)
(218), (108), (58), (51), (34), (26), (15), (11), (9), (7), (6), (5), (4), (3), (3), (2), (1), (1), (1)
Pubmed 1 reference available
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Product Details anti-IL2 Receptor beta Antibody

Target Details IL2 Receptor beta Application Details Handling References for anti-IL2 Receptor beta antibody (ABIN120200) Images
Specificity This antibody recognises the CD122 cell surface glycoprotein. Clone TM-beta 1 is reported to block IL-2 high affinity binding to the IL-2R beta receptor. We recommend the use of SM2224LE for this purpose.
Purification Affinity chromatography on Protein G
Endotoxin Level Low Endotoxin
Immunogen Cells from murine IL-2RB+ transformant TART-mBeta. Lymph node (cells from immunised Sprague Dawley rats were fused with cells of the mouse PA1 myeloma cell line.
Clone TM-BETA1
Isotype IgG2b

Target Details IL2 Receptor beta

Product Details anti-IL2 Receptor beta Antibody Application Details Handling References for anti-IL2 Receptor beta antibody (ABIN120200) Images back to top
Antigen
Alternative Name CD122 / IL2RB (IL2RB Antibody Abstract)
Background CD122 is a 75-85kD molecule also known as interleukin-2 receptor (IL-2R) beta chain. In mouse, CD122 is primarily expressed on natural killer (NK) cells and at lower levels on lymphocyte subsets, monocytes and macrophages. CD122 can associate with the IL-2R alpha chain (CD25) and CD132 to form a functional high affinity receptor complex that binds IL-2. CD132/CD122 heterodimers can also be formed which bind IL-2 with intermediate affinity. IL-2 binding to the IL-2R is important in the generation and differentiation of T lymphocytes and NK cells.Synonyms: IL-2 receptor subunit beta, IL2 Receptor beta, Interleukin-2 receptor subunit beta, P70-75
Gene ID 16185
NCBI Accession NP_032394
UniProt P16297
Pathways JAK-STAT Signaling, Growth Factor Binding

Application Details

Product Details anti-IL2 Receptor beta Antibody Target Details IL2 Receptor beta Handling References for anti-IL2 Receptor beta antibody (ABIN120200) Images back to top
Application Notes Flow Cytometry: 1/10 - 1/50, Use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL. Immunoprecipitation. Functional Assays.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-IL2 Receptor beta Antibody Target Details IL2 Receptor beta Application Details References for anti-IL2 Receptor beta antibody (ABIN120200) Images back to top
Concentration 1.0 mg/mL
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody at -20 °C to -70 °C.

References for anti-IL2 Receptor beta antibody (ABIN120200)

Product Details anti-IL2 Receptor beta Antibody Target Details IL2 Receptor beta Application Details Handling Images back to top
Background publications

Tanaka, Tsudo, Karasuyama, Kitamura, Kono, Hatakeyama, Taniguchi, Miyasaka: "A novel monoclonal antibody against murine IL-2 receptor beta-chain. Characterization of receptor expression in normal lymphoid cells and EL-4 cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 147, Issue 7, pp. 2222-8, 1991