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Cdc20 requires APC3 and APC8 to bind and activate the APC/C when the spindle assembly checkpoint is satisfied, but only APC8 when active, and APC10 is crucial for the destruction of cyclin B1 and securin, but not cyclin A
Substrates are recruited to the Anaphase-promoting complex by binding to a bipartite substrate receptor composed of Cdh1 and Doc1.
ANAPC10 was mainly expressed in the cytoplasm of spermatogonia and leptotene and pachytene spermatocytes.
Partial cDNA, intron 1 and 5'-flanking sequences of porcine APC10, were cloned and sequenced.
ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1\; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1\; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1\; MIM 116940) (summary by Wendt et al., 2001
anaphase-promoting complex subunit 10
, cyclosome subunit 10
, anaphase promoting complex subunit 10
, potential anaphase-promoting complex processivity factor Apc10
, hypothetical protein