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Human Polyclonal CCP110 Primary Antibody for ELISA, WB - ABIN4288914
DAngiolella, Donato, Vijayakumar, Saraf, Florens, Washburn, Dynlacht, Pagano: SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation. in Nature 2010
CP110 is required for anchoring of basal bodies to the membrane during cilia formation. CP110 loss resulted in an abnormal distribution of core components of subdistal appendages and of recycling endosomes, which may be associated with premature extension of axonemal microtubules. CP110 has unique context-dependent functions, acting as both a suppressor and a promoter of ciliogenesis.
miR-129-3p, a microRNA conserved in vertebrates, controls cilia biogenesis in cultured cells by concomitantly downregulating CP110 and repressing branched F-actin formation.
PLK4 specifically phosphorylates CP110 at the S98 position and is an essential step for centriole assembly.
This brief communication reports on a patient with an exceedingly rare "8p11 (eight-p-eleven) myeloproliferative syndrome" (EMS) with CEP110-FGFR1 rearrangement who responded to treatment with the multi-tyrosine kinase inhibitor (TKI) dasatinib
In tissues of prostate cancer patients, low CP110 and high miR-129-3p expression levels correlated with metastasi
We demonstrated that restoration of CP110 expression in MDA-MB-231 and MCF-7 cells by miR-129 overexpression rendered the cells sensitive to docetaxel.
Data show thata combining cyclin-dependent kinase 2 (CDK2) antagonism and ubiquitin thioesterase 33 (USP33) depletion augments anaphase catastrophe via changes in centrosomal protein of 110 kDa (CP110) protein expression.
CP110 plays a mechanistic role in response of lung cancer cells to CDK2 inhibition, especially in the presence of activated KRAS mutations.
Centrin2 regulates primary ciliogenesis through controlling CP110 levels.
Both protein and mRNA levels of ciliogenesis-associated markers CP110, Foxj1, TAp73 were significantly increased in patients with nasal polyps versus those seen in control subjects and were positively correlated with cilia length
using human cells, identification of a new mechanism for the regulation of centrosome duplication that requires USP33, a deubiquitinating enzyme that is able to regulate CP110 levels
Neurl4 counteracts accumulation of CP110, thereby maintaining normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centres
miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics.
Cp110 expression in mucosa from patients with chronic rhinosinusitis might contribute to the poor ciliation observed in these patients
Study found that loss of Kif24 leads to the disappearance of CP110 from mother centrioles in cycling cells able to form cilia; thus, identifying a centriolar kinesin that specifically remodels a subset of microtubules, thereby regulating cilia assembly.
SCF(Cyclin F)-mediated degradation of CP110 is required for the fidelity of mitosis and genome integrity
CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication (CP110)
These data demonstrate a functional role for CaM binding to CP110 and suggest that CP110 cooperates with CaM and centrin to regulate progression through cytokinesis.
CP110 suppresses a cilia assembly program.
The transition from centrioles to basal bodies is negatively regulated by CP11 protein.
These results suggest that CEP290 cooperates with Rab8a to promote ciliogenesis and that this function is antagonized by CP110.
Results suggest that CPAP and CP110 play antagonistic roles in determining the extent of tubulin addition during centriole elongation, thereby controlling the length of newly formed centrioles.
Necessary for centrosome duplication at different stages of procentriole formation. Collaborates with CEP97, being involved in the suppression of a cilia assembly program. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2.
centriolar coiled-coil protein of 110 kDa
, centrosomal protein CP110
, centrosomal protein of 110 kDa