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MAP4K3 is identified as an amino acid-dependent regulator of autophagy through its phosphorylation of transcription factor EB (TFEB (show TFEB Proteins)), a transcriptional activator of autophagy.
Data indicate that GLK/MAP4K3 is a prognostic biomarker for non-small cell lung cancer (NSCLC) recurrence.
Authors report that miR (show MLXIP Proteins)-199a-5p and let-7c cooperatively and efficiently inhibit HCC (show FAM126A Proteins) cell migration and invasion by targeting the metastasis promoter MAP4K3 and MAP4K3-mediated drug sensitization.
This report details the first structure of GLK (show GCK Proteins); comparison of its activation loop sequence and P-loop structure to that of Map4k4 (show MAP4K4 Proteins) suggests ideas for designing inhibitors that can distinguish between these family members to achieve selective pharmacological inhibitors.
ITGB3 (show ITGB3 Proteins) and MAP4K3 are directly repressed by let-7c, altering the metastatic potential of lung cancer cells.
MAP4K3 expression is required for leucine-induced mTORC1 activation in human primary fibroblasts.
Significantly higher median frequencies of circulating GLK (show GCK Proteins)-expressing T-cells were observed in patients with adult-onset Still's disease (31.85%) than in healthy volunteers (8.93%, P <0.001).
Amino acid sufficiency phosphorylates MAP4K3/Ser170, activating mTORC1, but amino acid restriction causes MAP4K3 to interact with PP2A (show PPP2R4 Proteins)(T61 epsilon), promoting dephosphorylation of Ser170, MAP4K3 inhibition, and, inhibition of mTORC1 signaling.
MAP4K3 orchestrates activation of BAX (show BAX Proteins) via the concerted posttranscriptional modulation of PUMA (show BBC3 Proteins), BAD, and BIM (show BCL2L11 Proteins).
This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.
MAPK/ERK kinase kinase kinase 3
, MEK kinase kinase 3
, germinal center kinase-like kinase
, germinal center kinase-related protein kinase
, MEKKK 3
, mitogen activated protein kinase kinase kinase kinase 3