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anti-Human YAP1 Antibodies:
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Human Polyclonal YAP1 Primary Antibody for ChIP, ICC - ABIN258559
Kapoor, Yao, Ying, Hua, Liewen, Wang, Zhong, Wu, Sadanandam, Hu, Chang, Chu, Al-Khalil, Jiang, Xia, Fletcher-Sananikone, Lim, Horwitz, Viale, Pettazzoni, Sanchez, Wang, Protopopov, Zhang, Heffernan et al.: Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer. ... in Cell 2014
Show all 24 Pubmed References
Human Monoclonal YAP1 Primary Antibody for IF, IHC (p) - ABIN564526
Lau, Murray, Houshmandi, Xu, Gutmann, Yu: Merlin is a potent inhibitor of glioma growth. in Cancer research 2008
Show all 17 Pubmed References
Human Monoclonal YAP1 Primary Antibody for FACS, IHC - ABIN969574
Fernandez-L, Northcott, Dalton, Fraga, Ellison, Angers, Taylor, Kenney: YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation. in Genes & development 2009
Show all 2 Pubmed References
Human Polyclonal YAP1 Primary Antibody for IF (p), IHC (p) - ABIN701485
Li, Shang, Shu, Zhang, Ji, Sun, Li, Xie: gga-miR-375 plays a key role in tumorigenesis post subgroup J avian leukosis virus infection. in PLoS ONE 2014
Human Monoclonal YAP1 Primary Antibody for IF, IHC - ABIN395579
Rose, Behm, Drgon, Johnson, Uhl: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. in Molecular medicine (Cambridge, Mass.) 2010
Show all 6 Pubmed References
Dog (Canine) Polyclonal YAP1 Primary Antibody for ELISA, WB - ABIN4219868
Zender, Spector, Xue, Flemming, Cordon-Cardo, Silke, Fan, Luk, Wigler, Hannon, Mu, Lucito, Powers, Lowe: Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. in Cell 2006
FAK (show PTK2 Antibodies) controls the nuclear translocation and activation of YAP in response to mechanical activation and submit that the YAP-dependent process of durotaxis requires a cell with an asymmetric distribution of active and inactive FAK (show PTK2 Antibodies) molecules.
Studies indicate that the transcriptional co-activators YAP and TAZ (show TAZ Antibodies) recently emerged as key mediators of the biological effects that are observed in response to extracellular matrix (ECM (show MMRN1 Antibodies)) elasticity and cell shape.
the tumor promoting role of YAP is involved in SHP2 which functions as a tumor promoter in vitro but as a tumor suppressor in vivo
The combined treatment significantly sensitized the A549/DDP (show TIMM8A Antibodies) cells to DDPinduced growth inhibition by reducing YAP promoter activity.
These results reveal a novel positive feedback loop involving CD44S and YAP1, in which CD44S functions as both an upstream regulator and a downstream effector of YAP1 in hepatocellular carcinoma.
hypoxic stress in the hepatocellular carcinoma (HCC)cells promoted YAP binding to HIF-1a in the nucleus and sustained HIF-1a protein stability to bind to PKM2 gene and directly activates PKM2 transcription to accelerate glycolysis
PTEN lipid phosphatase inactivation abolished the MOB1 (show MOBKL3 Antibodies)-LATS1/2 interaction, decreased YAP phosphorylation and finally promoted YAP nuclear translocation, which enhanced the synergistic effect of YAP-TEAD, thus inducing cell proliferation and migration.
Up-regulation of COPB2 (show COPB2 Antibodies) inhibited cell apoptosis and promoted cell growth and tumorigenesis through up-regulating YAP1 expression in lung adenocarcinoma.
In the present review, we focus on the functions of YAP/TAZ (show TAZ Antibodies) in cancer, discuss their potential as new therapeutic target for tumor treatment, and provide valuable suggestions for further study in this field.
HuR (show ELAVL1 Antibodies) acts as a tumor promoter by enhancing YAP expression in osteosarcoma cells.
Yap1 has a crucial role in controlling the limb regenerative capacity in Xenopus
Functional impairment of YAP/YAPdeltaC by mutant Atxn1 during development determines the adult pathology of spinocerebellar ataxia type 1 by suppressing RORalpha-mediated transcription.
Low YAP expression is associated with low liver regeneration.
these observations suggest that Zyxin (show ZYX Antibodies) promotes colon cancer tumorigenesis in a mitotic-phosphorylation-dependent manner and through CDK8 (show CDK8 Antibodies)-mediated YAP activation.
During and after liver development, the activation of YAP/TAZ induced by loss of Lats1/2 forces hepatoblasts or hepatocytes to commit to the biliary epithelial cell lineage.
YAP promotes myelin and non-myelin genes transcription while the polarity protein Crb3 (show CRB3 Antibodies), localized at the tips of the myelin sheath, activates the Hippo pathway to temper YAP activity, therefore allowing for optimal myelin growth.
The YAP/TEAD1 (show TEAD1 Antibodies) complex binds to DNA element and regulates the expression of genes involved in cell growth..our data demonstrate an important role of TEAD1 (show TEAD1 Antibodies) in early development in mice, and the floxed TEAD1 (show TEAD1 Antibodies) mouse model will be a valuable genetic tool to determine the temporal and tissue-specific functions of TEAD1 (show TEAD1 Antibodies).
RHOA (show RHOA Antibodies) loss reduces YAP signaling of the Hippo pathway and affects YAP effector epiregulin (EREG (show EREG Antibodies)) expression in the crypts. Expression of an active YAP (S112A) mutant rescues ntestinal stem cells (ISCs (show NFS1 Antibodies)) marker expression, ISC regeneration, and ISC-associated Wnt (show WNT2 Antibodies) signaling, but not defective epithelial polarity, in RhoA (show RHOA Antibodies) knockout mice, implicating YAP in RHOA (show RHOA Antibodies)-regulated ISC function.
YAP promotes the neurite outgrowth via targeting the promoter of miR (show MLXIP Antibodies)-29a, and it may be an effective therapeutic medicine for the neural disease.
Plk2 (show PLK2 Antibodies) acts as coordinator of cell proliferation and early lineage commitment in cardiac progenitor cells downstream of Yes-associated protein 1.
Physiologically, steroid sex hormones stimulate follicle growth by activating YAP1; however, the preovulatory inhibition of YAP1 activity in granulosa cells is a prerequisite of LH actions.
The authors show that the Hippo pathway transcriptional coactivators Yap1 and Wwtr1 (show WWTR1 Antibodies) are specifically localized to the presumptive epidermis and notochord, and play a critical and unexpected role in posterior body extension by regulating Fibronectin (show FN1 Antibodies) assembly underneath the presumptive epidermis and surrounding the notochord.
YAP activation is a hallmark of malignant brain tumours.
During vascular regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression.
that Yap1 entered the nucleus and promoted transcription in response to blood flow.
that Yap1 integrates the anabolic demands of tissue growth during development and tumorigenesis by reprogramming nitrogen metabolism to stimulate nucleotide biosynthesis
Amotl2a (show AMOTL2 Antibodies) function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 and the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) effector Lef1 (show LEF1 Antibodies).
data reveals that Yap is required for pronephric duct integrity, maintenance of baso-lateral cell polarity, and ciliogenesis during zebrafish kidney development
Yap/Taz (show TAZ Antibodies)-Tead activity is necessary and sufficient for optic vesicle progenitors to adopt retinal pigment epithelium identity in zebrafish.
Yap is essential for fin regeneration and that its function is dependent on mechanical tension, conferred by a balancing act of cell density and cytoskeleton activity.
When transcriptional coactivators Yap and Taz (show TAZ Antibodies) were restricted from interacting with Tead transcription factors through expression of a dominant negative transgene, cardiac precursors failed to migrate completely to the midline.
The data suggest that TEAD relocation and/or YAP degradation following its phosphorylation down-regulates IFNT gene transcription after conceptus attachment to the uterine endometrium.
This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction.
65 kDa Yes-associated protein
, yes-associated protein 2
, yorkie homolog
, Yes-associated protein 1, 65kDa
, Yes-associated protein 1, 65 kD
, yes-associated protein, 65 kDa