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anti-Human YAP1 Antibodies:
anti-Mouse (Murine) YAP1 Antibodies:
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Human Monoclonal YAP1 Primary Antibody for IF, IHC (p) - ABIN564526
Lau, Murray, Houshmandi, Xu, Gutmann, Yu: Merlin is a potent inhibitor of glioma growth. in Cancer research 2008
Show all 17 Pubmed References
Human Polyclonal YAP1 Primary Antibody for ChIP, ICC - ABIN258559
Kapoor, Yao, Ying, Hua, Liewen, Wang, Zhong, Wu, Sadanandam, Hu, Chang, Chu, Al-Khalil, Jiang, Xia, Fletcher-Sananikone, Lim, Horwitz, Viale, Pettazzoni, Sanchez, Wang, Protopopov, Zhang, Heffernan et al.: Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer. ... in Cell 2014
Show all 16 Pubmed References
Human Monoclonal YAP1 Primary Antibody for FACS, IHC - ABIN969574
Fernandez-L, Northcott, Dalton, Fraga, Ellison, Angers, Taylor, Kenney: YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation. in Genes & development 2009
Show all 2 Pubmed References
Human Polyclonal YAP1 Primary Antibody for IF (p), IHC (p) - ABIN701485
Li, Shang, Shu, Zhang, Ji, Sun, Li, Xie: gga-miR-375 plays a key role in tumorigenesis post subgroup J avian leukosis virus infection. in PLoS ONE 2014
Human Polyclonal YAP1 Primary Antibody for ICC, IF - ABIN4366489
Li, Lim, Chen, McCabe, Kim, Zhang, Mao: Spinal expression of Hippo signaling components YAP and TAZ following peripheral nerve injury in rats. in Brain research 2013
Dog (Canine) Polyclonal YAP1 Primary Antibody for ELISA, WB - ABIN4219868
Zender, Spector, Xue, Flemming, Cordon-Cardo, Silke, Fan, Luk, Wigler, Hannon, Mu, Lucito, Powers, Lowe: Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. in Cell 2006
Studies indicate that the transcriptional co-activators YAP and TAZ (show TAZ Antibodies) recently emerged as key mediators of the biological effects that are observed in response to extracellular matrix (ECM (show MMRN1 Antibodies)) elasticity and cell shape.
YAP promotes the expression of ARHGAP29 to suppress the RhoA-LIMK-cofilin pathway, destabilizing F-actin.
The close relationship between YAP/TAZ (show TAZ Antibodies) and Ki-67 (show MKI67 Antibodies).
Results found YAP1 overexpressed in lung cancer side population cells. YAP1 regulates ABCG2 at the transcriptional level through binding to the promoter of ABCG2. The study adds a new function for YAP1 that may be relevant to drug resistance and cancer therapy through regulation of ABCG2 and side population cell formation in lung cancer.
YAP1 overexpression is a marker of poor prognosis for pediatric patients with adrenocortical tumors
YAP/ TAZ (show TAZ Antibodies) pathways contribute to the proliferation/quiescence switch during colon cancer 5FU treatment according to the concerted regulation of Cyclin E1 (show CCNE1 Antibodies) and CREB (show CREB1 Antibodies)
Yap1 post-translational modifications favoring its ubiquitination and apoptosis characterize hepatocellular carcinoma (HCC (show FAM126A Antibodies)) with better prognosis, whereas conditions favoring the formation of YAP1-TEAD complexes are associated with aggressiveness and acquisition of stemness features by HCC (show FAM126A Antibodies) cells
Angiomotin (show AMOT Antibodies) promotes prostate cancer cell proliferation by signaling through the Hippo-YAP pathway.
Results suggest that YAP1 is not a direct factor affecting gastric tumor formation, but could accelerate tumor growth and metastasis.
this study indicates that YAP proteins are linked to prognosis and therefore could be therapeutic targets in conventional osteosarcomas
Yap1 has a crucial role in controlling the limb regenerative capacity in Xenopus
Collectively, these data indicate that Yap-induced Epiregulin (show EREG Antibodies) signaling promotes the identity of submandibular gland ductal progenitors and that removal of nuclear Yap by Lats1 (show LATS1 Antibodies)/2-mediated signaling is critical for proper ductal maturation.
The authors show that active YAP, a key mediator of Hippo signaling, is distributed throughout the murine lung epithelium and loss of epithelial YAP severely disrupts branching. Failure to branch is restricted to regions where YAP activity is removed. This suggests that YAP controls local epithelial cell properties.
Collectively, our results defined netrin-1 (show NTN1 Antibodies) as a positive regulator of malignant tumor metastasis in GC by activating the YAP signaling, with potential implications for new approaches to GC therapy.
Decrease in actin tension and YAP inactivation should be crucially involved in the cytotoxicity of ethanol on HL-1 (show ASGR1 Antibodies) cardiomyocytes.
The results of this study indicated that YAP regulates oligodendrocyte morphology and maturation in response to mechanical factors.
Study found that the extracellular matrix protein laminin-511 (show LAMA5 Antibodies) (LM511) promoted the survival and differentiation of dopaminergic neurons in the midbrain neurons. LM511 bound to integrin alpha3beta1 and activated the transcriptional cofactor YAP.
YAP accumulated in nuclei of mammary glands in ErbB2 (show ERBB2 Antibodies)/EGFR (show EGFR Antibodies)-transgenic mice, suggesting that EGFR (show EGFR Antibodies) signaling affects YAP in vivo similar to cell culture. ErbB2 (show ERBB2 Antibodies)/EGFR (show EGFR Antibodies)-transgenic mice develop mammary tumors in 7-8 months, but surprisingly, MaSCs from these mice did not form tumors when transplanted into host mice.
Therefore, YAP/TAZ (show TAZ Antibodies) are crucial for Schwann cells to myelinate developing nerve and to maintain myelinated nerve in adulthood.
Collectively, we have uncovered that AMOT (show AMOT Antibodies) acts as a YAP stimulator in high glucose level.
YAP1 enhanced cementoblast mineralization in vitro. YAP1 exerted its effect on the cementoblast partly by regulating the Smad-dependent BMP and Erk1/2 signaling pathways.
YAP activation is a hallmark of malignant brain tumours.
During vascular regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression.
that Yap1 entered the nucleus and promoted transcription in response to blood flow.
that Yap1 integrates the anabolic demands of tissue growth during development and tumorigenesis by reprogramming nitrogen metabolism to stimulate nucleotide biosynthesis
Amotl2a (show AMOTL2 Antibodies) function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 and the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) effector Lef1 (show LEF1 Antibodies).
data reveals that Yap is required for pronephric duct integrity, maintenance of baso-lateral cell polarity, and ciliogenesis during zebrafish kidney development
Yap/Taz (show TAZ Antibodies)-Tead activity is necessary and sufficient for optic vesicle progenitors to adopt retinal pigment epithelium identity in zebrafish.
Yap is essential for fin regeneration and that its function is dependent on mechanical tension, conferred by a balancing act of cell density and cytoskeleton activity.
When transcriptional coactivators Yap and Taz (show TAZ Antibodies) were restricted from interacting with Tead transcription factors through expression of a dominant negative transgene, cardiac precursors failed to migrate completely to the midline.
Yap coordinately regulates cell proliferation and apoptosis and is required for dorsoventral axis formation, gastrulation, cardiogenesis, hematopoiesis, and somitogenesis.
The data suggest that TEAD relocation and/or YAP degradation following its phosphorylation down-regulates IFNT gene transcription after conceptus attachment to the uterine endometrium.
This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction.
65 kDa Yes-associated protein
, yes-associated protein 2
, yorkie homolog
, Yes-associated protein 1, 65kDa
, Yes-associated protein 1, 65 kD
, yes-associated protein, 65 kDa