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anti-Human YAP1 Antibodies:
anti-Mouse (Murine) YAP1 Antibodies:
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Human Monoclonal YAP1 Primary Antibody for IF, IHC (p) - ABIN564526
Lau, Murray, Houshmandi, Xu, Gutmann, Yu: Merlin is a potent inhibitor of glioma growth. in Cancer research 2008
Show all 17 Pubmed References
Human Polyclonal YAP1 Primary Antibody for ChIP, ICC - ABIN258559
Kapoor, Yao, Ying, Hua, Liewen, Wang, Zhong, Wu, Sadanandam, Hu, Chang, Chu, Al-Khalil, Jiang, Xia, Fletcher-Sananikone, Lim, Horwitz, Viale, Pettazzoni, Sanchez, Wang, Protopopov, Zhang, Heffernan et al.: Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer. ... in Cell 2014
Show all 16 Pubmed References
Human Monoclonal YAP1 Primary Antibody for FACS, IHC - ABIN969574
Fernandez-L, Northcott, Dalton, Fraga, Ellison, Angers, Taylor, Kenney: YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation. in Genes & development 2009
Show all 2 Pubmed References
Human Polyclonal YAP1 Primary Antibody for IF (p), IHC (p) - ABIN701485
Li, Shang, Shu, Zhang, Ji, Sun, Li, Xie: gga-miR-375 plays a key role in tumorigenesis post subgroup J avian leukosis virus infection. in PLoS ONE 2014
Human Polyclonal YAP1 Primary Antibody for ICC, IF - ABIN4366489
Li, Lim, Chen, McCabe, Kim, Zhang, Mao: Spinal expression of Hippo signaling components YAP and TAZ following peripheral nerve injury in rats. in Brain research 2013
Dog (Canine) Polyclonal YAP1 Primary Antibody for ELISA, WB - ABIN4219868
Zender, Spector, Xue, Flemming, Cordon-Cardo, Silke, Fan, Luk, Wigler, Hannon, Mu, Lucito, Powers, Lowe: Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. in Cell 2006
No significant correlations emerged for YAP or AREG (show AREG Antibodies) expression and VIII (show COX8A Antibodies) CN schwannoma volume.
MEKK3 (show MAP3K3 Antibodies) KO reduced both EMT (show ITK Antibodies) and cell migration, the size of 3D colonies and the percentage of CD44 (show CD44 Antibodies)(+)/CD24 (show CD24 Antibodies)(+)/EpCAM (show EPCAM Antibodies)(+) CSC, promoter recruitment of YAP/TAZ (show TAZ Antibodies) and the expression of their target genes.
we also found that FGF8 (show FGF8 Antibodies) increased the expression of YAP1 and knockdown of YAP1 eliminated the upregulation of EGFR (show EGFR Antibodies) and the resistance to EGFR (show EGFR Antibodies) inhibition induced by FGF8 (show FGF8 Antibodies). Our study provides evidence that FGF8 (show FGF8 Antibodies) plays an important role in the resistance to EGFR (show EGFR Antibodies) inhibition of human hepatocellular carcinoma cells
Data show that tumor suppressor adenomatous polyposis coli (APC (show APC Antibodies)) loss results in up-regulation of IL-6 (show IL6 Antibodies) signal transducer (IL-6ST/gp130 (show IL6ST Antibodies)), thereby activating YAP (YY1 (show YY1 Antibodies)-associated) protein (YAP) which are simultaneously up-regulated in the majority of colorectal cancer (CRC (show CALR Antibodies)).
Hedgehog (show SHH Antibodies)-YAP signaling pathway regulates glutaminolysis to control activation of hepatic stellate cells and their transdifferentiation into myofibroblasts.
Studies indicate that the transcriptional co-activators YAP and TAZ (show TAZ Antibodies) recently emerged as key mediators of the biological effects that are observed in response to extracellular matrix (ECM (show MMRN1 Antibodies)) elasticity and cell shape.
The results of the present study suggested that miR205 inhibited glioma growth and metastasis by directly targeting YAP1.
data show an association of YAP-1 expression with worse clinicopathologic features of thyroid tumors that seem to have a specific impact on outcome
Our findings strongly suggested that 5-HT (show DDC Antibodies) and Yap, which acted as a promoter of HCC (show FAM126A Antibodies), might be prognostic predictors for HCC (show FAM126A Antibodies) patients.
Collectively, these results show that inhibition of YAP inhibits proliferation and induces apoptosis in HL-60 cells. Therefore, a novel treatment regime involving genetic or pharmacological inhibition of YAP could be established for acute promyelocytic leukemia (show PML Antibodies).
Yap1 has a crucial role in controlling the limb regenerative capacity in Xenopus
The role of Yap and Wwtr1 (show WWTR1 Antibodies) in the Hippo signaling pathway and the regulation of spermatogenesis in mice are reported.
demonstrated the nuclear expression of transcriptional coactivator YAP1 in the limbal and corneal basal epithelial cells and its essential role for maintaining the high proliferative potential of those corneal epithelial progenitor cells in vivo
Taz (show TAZ Antibodies) and Yap have overlapping functions in promoting myoblast proliferation but Taz (show TAZ Antibodies) then switches to enhance myogenic differentiation.
identified a pathway involving activation of integrin alpha3 in TA cells that signals through an LATS (show LATS1 Antibodies)-independent FAK (show PTK2 Antibodies)/CDC42 (show CDC42 Antibodies)/PP1A (show PPP1CA Antibodies) cascade to control YAP-S397 phosphorylation and nuclear localization.
thiazolidinediones (PPARgamma (show PPARG Antibodies) agonists) promote differentiation of cancer stem cells by restraining YAP transcriptional activity
RASSF1A (show RASSF1 Antibodies) mediates transcription factor selection of YAP in stem cells.YAP induces OCT4 (show POU5F1 Antibodies) expression.
Collectively, these data indicate that Yap-induced Epiregulin (show EREG Antibodies) signaling promotes the identity of submandibular gland ductal progenitors and that removal of nuclear Yap by Lats1 (show LATS1 Antibodies)/2-mediated signaling is critical for proper ductal maturation.
The authors show that active YAP, a key mediator of Hippo signaling, is distributed throughout the murine lung epithelium and loss of epithelial YAP severely disrupts branching. Failure to branch is restricted to regions where YAP activity is removed. This suggests that YAP controls local epithelial cell properties.
Collectively, our results defined netrin-1 (show NTN1 Antibodies) as a positive regulator of malignant tumor metastasis in GC by activating the YAP signaling, with potential implications for new approaches to GC therapy.
YAP activation is a hallmark of malignant brain tumours.
During vascular regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression.
that Yap1 entered the nucleus and promoted transcription in response to blood flow.
that Yap1 integrates the anabolic demands of tissue growth during development and tumorigenesis by reprogramming nitrogen metabolism to stimulate nucleotide biosynthesis
Amotl2a (show AMOTL2 Antibodies) function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 and the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) effector Lef1 (show LEF1 Antibodies).
data reveals that Yap is required for pronephric duct integrity, maintenance of baso-lateral cell polarity, and ciliogenesis during zebrafish kidney development
Yap/Taz (show TAZ Antibodies)-Tead activity is necessary and sufficient for optic vesicle progenitors to adopt retinal pigment epithelium identity in zebrafish.
Yap is essential for fin regeneration and that its function is dependent on mechanical tension, conferred by a balancing act of cell density and cytoskeleton activity.
When transcriptional coactivators Yap and Taz (show TAZ Antibodies) were restricted from interacting with Tead transcription factors through expression of a dominant negative transgene, cardiac precursors failed to migrate completely to the midline.
Yap coordinately regulates cell proliferation and apoptosis and is required for dorsoventral axis formation, gastrulation, cardiogenesis, hematopoiesis, and somitogenesis.
The data suggest that TEAD relocation and/or YAP degradation following its phosphorylation down-regulates IFNT gene transcription after conceptus attachment to the uterine endometrium.
This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction.
65 kDa Yes-associated protein
, yes-associated protein 2
, yorkie homolog
, Yes-associated protein 1, 65kDa
, Yes-associated protein 1, 65 kD
, yes-associated protein, 65 kDa