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anti-Human YAP1 Antibodies:
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Human Monoclonal YAP1 Primary Antibody for IF, IHC (p) - ABIN564526
Lau, Murray, Houshmandi, Xu, Gutmann, Yu: Merlin is a potent inhibitor of glioma growth. in Cancer research 2008
Show all 17 Pubmed References
Human Polyclonal YAP1 Primary Antibody for ChIP, ICC - ABIN258559
Kapoor, Yao, Ying, Hua, Liewen, Wang, Zhong, Wu, Sadanandam, Hu, Chang, Chu, Al-Khalil, Jiang, Xia, Fletcher-Sananikone, Lim, Horwitz, Viale, Pettazzoni, Sanchez, Wang, Protopopov, Zhang, Heffernan et al.: Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer. ... in Cell 2014
Show all 16 Pubmed References
Human Monoclonal YAP1 Primary Antibody for FACS, IHC - ABIN969574
Fernandez-L, Northcott, Dalton, Fraga, Ellison, Angers, Taylor, Kenney: YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation. in Genes & development 2009
Show all 2 Pubmed References
Dog (Canine) Polyclonal YAP1 Primary Antibody for ELISA, WB - ABIN4219868
Zender, Spector, Xue, Flemming, Cordon-Cardo, Silke, Fan, Luk, Wigler, Hannon, Mu, Lucito, Powers, Lowe: Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. in Cell 2006
Human Polyclonal YAP1 Primary Antibody for IF (p), IHC (p) - ABIN701485
Li, Shang, Shu, Zhang, Ji, Sun, Li, Xie: gga-miR-375 plays a key role in tumorigenesis post subgroup J avian leukosis virus infection. in PLoS ONE 2014
Human Polyclonal YAP1 Primary Antibody for ICC, IF - ABIN4366489
Li, Lim, Chen, McCabe, Kim, Zhang, Mao: Spinal expression of Hippo signaling components YAP and TAZ following peripheral nerve injury in rats. in Brain research 2013
Bioinformatics analysis and luciferase reporter assays indicated that miR625 targeted the 3'untranslated region of Yesassociated protein 1 (YAP1).
Studies indicate that the transcriptional co-activators YAP and TAZ (show TAZ Antibodies) recently emerged as key mediators of the biological effects that are observed in response to extracellular matrix (ECM (show MMRN1 Antibodies)) elasticity and cell shape.
functional evaluation of a HTM cell monolayer using a permeability assay demonstrated that the inhibition of YAP and TAZ (show TAZ Antibodies) attenuated the DEX-induced impairment of permeability. These findings suggest that YAP and TAZ (show TAZ Antibodies) play pivotal roles in the DEX-induced cytoskeletal changes of HTM cells, and reveal novel potential mechanisms for the development and progression of glaucoma
the role of YAP in deciding cell competitions depends on metabolic factors and the status of neighboring cells
we found that nuclear translocation of yes-associated protein (YAP) was regulated by cisplatin-induced autophagy, and we identified YAP as a survival input that promoted survival in cisplatin-treated breast cancer cells
EphA2 (show EPHA2 Antibodies)-mediates glutaminolysis through YAP/TAZ (show TAZ Antibodies) activation in HER2 (show ERBB2 Antibodies)-positive breast cancer and may serve as potential therapeutic targets in patients.
data reveal that YAP promotes metastasis of breast cancer cells by repressing GDF15 (show GDF15 Antibodies) transcription and present a novel molecular mechanism underlying the pro-metastasis function of YAP oncoprotein, with the implication of a therapeutic avenue for breast cancer treatment.
we provide evidence that S100A7 (show S100A7 Antibodies) also inhibits YAP expression and activity through p65 (show GORASP1 Antibodies)/NFkappaB (show NFKB1 Antibodies)-mediated repression of DeltaNp63, and S100A7 (show S100A7 Antibodies) represses drug-induced apoptosis via inhibition of YAP.
Findings identify that YAP promotes human glioma growth through enhancing Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling.
Here, the cross-talk between these pathways and the impact on eRMS tumorigenesis is reported. Using human eRMS cells grown as three-dimensional (3D) rhabdospheres, which enriches in stem cells, it was found that Notch (show NOTCH1 Antibodies) signaling transcriptionally upregulates YAP1 gene expression and YAP activity.
Yap1 has a crucial role in controlling the limb regenerative capacity in Xenopus
RHOA (show RHOA Antibodies) loss reduces YAP signaling of the Hippo pathway and affects YAP effector epiregulin (EREG (show EREG Antibodies)) expression in the crypts. Expression of an active YAP (S112A) mutant rescues ntestinal stem cells (ISCs (show NFS1 Antibodies)) marker expression, ISC regeneration, and ISC-associated Wnt (show WNT2 Antibodies) signaling, but not defective epithelial polarity, in RhoA (show RHOA Antibodies) knockout mice, implicating YAP in RHOA (show RHOA Antibodies)-regulated ISC function.
YAP promotes the neurite outgrowth via targeting the promoter of miR (show MLXIP Antibodies)-29a, and it may be an effective therapeutic medicine for the neural disease.
Plk2 (show PLK2 Antibodies) acts as coordinator of cell proliferation and early lineage commitment in cardiac progenitor cells downstream of Yes-associated protein 1.
Physiologically, steroid sex hormones stimulate follicle growth by activating YAP1; however, the preovulatory inhibition of YAP1 activity in granulosa cells is a prerequisite of LH actions.
MOB1 (show HOPX Antibodies)-dependent YAP1/TAZ (show TAZ Antibodies)-TEAD complex functions as a transcriptional repressor of SOX9 (show SOX9 Antibodies) and thereby negatively regulates chondrogenesis.
Hedgehog (show SHH Antibodies)-YAP signaling pathway regulates glutaminolysis to control activation of hepatic stellate cells and their transdifferentiation into myofibroblasts.
The role of Yap and Wwtr1 (show WWTR1 Antibodies) in the Hippo signaling pathway and the regulation of spermatogenesis in mice are reported.
demonstrated the nuclear expression of transcriptional coactivator YAP1 in the limbal and corneal basal epithelial cells and its essential role for maintaining the high proliferative potential of those corneal epithelial progenitor cells in vivo
Taz (show TAZ Antibodies) and Yap have overlapping functions in promoting myoblast proliferation but Taz (show TAZ Antibodies) then switches to enhance myogenic differentiation.
identified a pathway involving activation of integrin alpha3 in TA cells that signals through an LATS (show LATS1 Antibodies)-independent FAK (show PTK2 Antibodies)/CDC42 (show CDC42 Antibodies)/PP1A (show PPP1CA Antibodies) cascade to control YAP-S397 phosphorylation and nuclear localization.
YAP activation is a hallmark of malignant brain tumours.
During vascular regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression.
that Yap1 entered the nucleus and promoted transcription in response to blood flow.
that Yap1 integrates the anabolic demands of tissue growth during development and tumorigenesis by reprogramming nitrogen metabolism to stimulate nucleotide biosynthesis
Amotl2a (show AMOTL2 Antibodies) function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 and the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) effector Lef1 (show LEF1 Antibodies).
data reveals that Yap is required for pronephric duct integrity, maintenance of baso-lateral cell polarity, and ciliogenesis during zebrafish kidney development
Yap/Taz (show TAZ Antibodies)-Tead activity is necessary and sufficient for optic vesicle progenitors to adopt retinal pigment epithelium identity in zebrafish.
Yap is essential for fin regeneration and that its function is dependent on mechanical tension, conferred by a balancing act of cell density and cytoskeleton activity.
When transcriptional coactivators Yap and Taz (show TAZ Antibodies) were restricted from interacting with Tead transcription factors through expression of a dominant negative transgene, cardiac precursors failed to migrate completely to the midline.
Yap coordinately regulates cell proliferation and apoptosis and is required for dorsoventral axis formation, gastrulation, cardiogenesis, hematopoiesis, and somitogenesis.
The data suggest that TEAD relocation and/or YAP degradation following its phosphorylation down-regulates IFNT gene transcription after conceptus attachment to the uterine endometrium.
This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction.
65 kDa Yes-associated protein
, yes-associated protein 2
, yorkie homolog
, Yes-associated protein 1, 65kDa
, Yes-associated protein 1, 65 kD
, yes-associated protein, 65 kDa