Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species and application
anti-Human YAP1 Antibodies:
anti-Mouse (Murine) YAP1 Antibodies:
anti-Rat (Rattus) YAP1 Antibodies:
Go to our pre-filtered search.
Human Polyclonal YAP1 Primary Antibody for ChIP, ICC - ABIN258559
Kapoor, Yao, Ying, Hua, Liewen, Wang, Zhong, Wu, Sadanandam, Hu, Chang, Chu, Al-Khalil, Jiang, Xia, Fletcher-Sananikone, Lim, Horwitz, Viale, Pettazzoni, Sanchez, Wang, Protopopov, Zhang, Heffernan et al.: Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer. ... in Cell 2014
Show all 24 Pubmed References
Human Monoclonal YAP1 Primary Antibody for IF, IHC (p) - ABIN564526
Lau, Murray, Houshmandi, Xu, Gutmann, Yu: Merlin is a potent inhibitor of glioma growth. in Cancer research 2008
Show all 17 Pubmed References
Human Polyclonal YAP1 Primary Antibody for FACS, IHC - ABIN6674128
Zhang, Pei, Wang, Xiang, Sun, Cheng, Qi, Marchetti, Xu, Sun, Edgar, Yuan: A Balance of Yki/Sd Activator and E2F1/Sd Repressor Complexes Controls Cell Survival and Affects Organ Size. in Developmental cell 2018
Show all 4 Pubmed References
Human Polyclonal YAP1 Primary Antibody for FACS, IHC - ABIN5663829
Gao, Yang, Yuan, Huang, Xu, Mao, Yuan, Bi: TNFα-YAP/p65-HK2 axis mediates breast cancer cell migration. in Oncogenesis 2017
Show all 4 Pubmed References
Polyclonal YAP1 Primary Antibody for IHC (p), IP - ABIN540874
Dong, Loukinova, Chen, Gangi, Chanturita, Liu, Van Waes et al.: Molecular profiling of transformed and metastatic murine squamous carcinoma cells by differential display and cDNA microarray reveals altered expression of multiple genes related to growth, ... in Cancer research 2001
Show all 3 Pubmed References
Human Monoclonal YAP1 Primary Antibody for FACS, IHC - ABIN969574
Fernandez-L, Northcott, Dalton, Fraga, Ellison, Angers, Taylor, Kenney: YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation. in Genes & development 2009
Show all 2 Pubmed References
Human Polyclonal YAP1 Primary Antibody for IHC, WB - ABIN6689882
Wang, Xiu, Chen, Sun, Chen, Wu, Liu, Zhao: The transcription factor FOXA1 induces epithelial ovarian cancer tumorigenesis and progression. in Tumour biology 2017
Show all 2 Pubmed References
Human Polyclonal YAP1 Primary Antibody for IHC, WB - ABIN6150315
Zhang, Gong, Sun, Huang, Fan: Enhanced osteogenic differentiation of MC3T3-E1 cells on grid-topographic surface and evidence for involvement of YAP mediator. in Journal of biomedical materials research. Part A 2016
Show all 2 Pubmed References
Human Polyclonal YAP1 Primary Antibody for IF (p), IHC (p) - ABIN701485
Li, Shang, Shu, Zhang, Ji, Sun, Li, Xie: gga-miR-375 plays a key role in tumorigenesis post subgroup J avian leukosis virus infection. in PLoS ONE 2014
Human Monoclonal YAP1 Primary Antibody for IF, IHC - ABIN395579
Rose, Behm, Drgon, Johnson, Uhl: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. in Molecular medicine (Cambridge, Mass.) 2010
Show all 6 Pubmed References
YAP1-TEAD1 signaling induces mitochondrial biogenesis in endothelial cells and stimulates angiogenesis through PGC1alpha.
TAZ/YAP is highly expressed in malignant melanoma tumor tissues; high expression of TAZ/YAP promotes the progression of malignant melanoma and affects the postoperative survival of patients.
Studies indicate that the transcriptional co-activators YAP and TAZ recently emerged as key mediators of the biological effects that are observed in response to extracellular matrix (ECM) elasticity and cell shape.
we first identified that YAP1 can modulate tumour-associated MDSC induction through suppressing PTEN expression to activate P-AKT, P-p65 and COX-2 and subsequently induce the secretion of GM-CSF, which is associated with the expansion of MDSCs in CRC
Cthrc1 may play a role in the pathogenesis of keloid by inhibiting collagen synthesis and fibroblasts migration via suppressing TGF-b/Smad pathway and YAP nucleus translocation
The microRNA-590-5p/YAP axis plays an important role in the chemotherapeutic resistance of hepatocellular carcinoma.
Results illuminate how the extracellular matrix glycoprotein tenascin-C in the tumor microenvironment promotes invasive migration and metastatic progression by employing integrin alpha9beta1, abolishing actin stress fiber formation, inhibiting YAP and its target gene expression.
lncRNA kcna3 exerts a tumor-inhibit role in colorectal cancer progression through down-regulating YAP1 expression.
This study identified circRNA-000425 as a new inhibitory target of YAP1, and also found that it binds to miR-17/miR-106b, and thus suppresses cancer cell growth induced by these miRNAs.
YAP activation is critical for the recruitment of tumor-associated macrophages towards Hepatocellular carcinoma cells.
TRPS1 is an epigenetic regulator of YAP activity in breast cancer
human spindle cell carcinoma also feature strong nuclear localisation of YAP.
Activated YAP promotes proliferation, inhibits apoptosis, and delays senescence of human periodontal ligament stem cellss. The Hippo-YAP signaling pathway can influence ERK and Bcl-2 signaling pathways.
ARRDC3 suppresses colorectal cancer progression through destabilizing the oncoprotein YAP
loss of p53 or LKB1 relieves DVL-linked reciprocal inhibition between the Wnt and nuclear YAP activity
that lncRNA B4GALT1-AS1 promotes OS cells stemness and migration via recruiting HuR to enhance YAP activity
The miR-590-5p/YAP axis may be an important novel mechanism in the pathogenesis of CD and colorectal cancer.
The observed decrease in total YAP levels in endothelial cells exposed to pulsatile flow is due to degradation via a proteasome-independent mechanism.
disruption of TAZ/YAP activity alleviates tumor burden in Lats1/2-deficient mice and inhibits human malignant peripheral nerve sheath tumors cell proliferation
Molecular mechanisms of YAP protein in the lung physiological conditions and lung diseases.[review]
Yap1 has a crucial role in controlling the limb regenerative capacity in Xenopus
Yap is not essential for achieving proper liver size during development or in the perinatal period but is required to mount an effective regenerative response following hepatectomy.
The fate change is orchestrated by remodeling the extracellular matrix (ECM), increased FAK/Src signaling, and ultimately YAP/TAZ activation.
These data demonstrate that YAP and TAZ combinatorially promote bone development through regulation of osteoblast activity, matrix quality, and osteoclastic remodeling.
Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis
Expression of mutant GNAS caused phosphorylated YAP1 to be sequestered in the cytoplasm, altering tumor progression.
Using liver cancer as a model, NUAK2 was identified as an essential mediator of YAP-driven hepatomegaly and tumorigenesis in vivo.
YAP determines the cell fate of injured mouse hepatocytes in vivo.
YAP1 and the YAP1-TEADs complex have roles in regulating osteoclastogenesis and related gene expression
Inhibition of YAP ameliorates choroidal neovascularization via inhibiting endothelial cell proliferation.
YAP/TAZ mechanotransduction integrates with cell-cell communication pathways for fine-grained orchestration of stem cell decisions.
Nuclear expression of YAP1 is detected in a small subset of hepatic cells starting at embryonic day (E) 13.5 when the hepatoblasts begin to differentiate into hepatocytes and cholangiocytes. At E18.5, nuclear YAP1 is undetectable in hepatoblasts & hepatocytes, but enriched within the nuclei of cholangiocytes. These levels remain postnatally, consistent with the role of YAP1 in cholangiocyte specification and maintenance.
The results indicate that EGFR and its activation are critical for YAP-mediated suppression of TGF-beta1-induced apoptosis. This study provides a new understanding of the regulatory mechanism underlying the determination of cell fate in response to TGF-beta1-mediated simultaneous apoptosis and epithelial mesenchymal transformation.
Fat4 is not required for the canonical activation of Hippo kinases but it sequesters a partner of Yap1, Amotl1, out of the nucleus.
Functional impairment of YAP/YAPdeltaC by mutant Atxn1 during development determines the adult pathology of spinocerebellar ataxia type 1 by suppressing RORalpha-mediated transcription.
Low YAP expression is associated with low liver regeneration.
these observations suggest that Zyxin promotes colon cancer tumorigenesis in a mitotic-phosphorylation-dependent manner and through CDK8-mediated YAP activation.
During and after liver development, the activation of YAP/TAZ induced by loss of Lats1/2 forces hepatoblasts or hepatocytes to commit to the biliary epithelial cell lineage.
YAP promotes myelin and non-myelin genes transcription while the polarity protein Crb3, localized at the tips of the myelin sheath, activates the Hippo pathway to temper YAP activity, therefore allowing for optimal myelin growth.
The YAP/TEAD1 complex binds to DNA element and regulates the expression of genes involved in cell growth..our data demonstrate an important role of TEAD1 in early development in mice, and the floxed TEAD1 mouse model will be a valuable genetic tool to determine the temporal and tissue-specific functions of TEAD1.
Disrupted gene function in yap1(-/-); taz(+/-) embryos did not disturb liver bud formation, but instead impaired cell proliferation in liver and movement of the neighboring lateral plate mesoderm (LPM). Overexpression of wild type yap1 or taz could rescue the defective liver phenotypes in yap1(-/-); taz(+/-) embryos.
The authors show that the Hippo pathway transcriptional coactivators Yap1 and Wwtr1 are specifically localized to the presumptive epidermis and notochord, and play a critical and unexpected role in posterior body extension by regulating Fibronectin assembly underneath the presumptive epidermis and surrounding the notochord.
YAP activation is a hallmark of malignant brain tumours.
During vascular regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression.
that Yap1 entered the nucleus and promoted transcription in response to blood flow.
that Yap1 integrates the anabolic demands of tissue growth during development and tumorigenesis by reprogramming nitrogen metabolism to stimulate nucleotide biosynthesis
Amotl2a function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 and the Wnt/beta-catenin effector Lef1.
data reveals that Yap is required for pronephric duct integrity, maintenance of baso-lateral cell polarity, and ciliogenesis during zebrafish kidney development
Yap/Taz-Tead activity is necessary and sufficient for optic vesicle progenitors to adopt retinal pigment epithelium identity in zebrafish.
Yap is essential for fin regeneration and that its function is dependent on mechanical tension, conferred by a balancing act of cell density and cytoskeleton activity.
When transcriptional coactivators Yap and Taz were restricted from interacting with Tead transcription factors through expression of a dominant negative transgene, cardiac precursors failed to migrate completely to the midline.
Yap coordinately regulates cell proliferation and apoptosis and is required for dorsoventral axis formation, gastrulation, cardiogenesis, hematopoiesis, and somitogenesis.
zebrafish yap is required for the development of the brain, eyes, and neural crest during embryogenesis.
The data suggest that TEAD relocation and/or YAP degradation following its phosphorylation down-regulates IFNT gene transcription after conceptus attachment to the uterine endometrium.
This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction.
65 kDa Yes-associated protein
, yes-associated protein 2
, yorkie homolog
, Yes-associated protein 1, 65kDa
, Yes-associated protein 1, 65 kD
, yes-associated protein, 65 kDa