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MCAM Proteins

(Melanoma Cell Adhesion Molecule (MCAM))
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

24 results

MCAM Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Catalog No. ABIN7275301
$445.92
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 11 to 13 Business Days
 
MCAM Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Pubmed 1 reference
Catalog No. ABIN1310514
-15% Promotion 2026
$476.85
$561.00
save $84.15 (-15 %)
Plus shipping costs $50.00, if applicable $20.00 dry ice
10 μg (More quantities available)
Shipping to: United States
Delivery in 11 to 12 Business Days
 
MCAM Origin: Human Host: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Catalog No. ABIN2752854
-15% Promotion 2026
$586.55
$690.06
save $103.51 (-15 %)
Plus shipping costs $50.00
2 μg
Shipping to: United States
Delivery in 11 to 12 Business Days
 
MCAM Origin: Mouse Host: HEK-293 Cells Recombinant > 98 % as determined by SDS-PAGE
Catalog No. ABIN7196965
-15% Promotion 2026
$525.91
$618.72
save $92.81 (-15 %)
Plus shipping costs $50.00
50 μg
Shipping to: United States
Delivery in 11 to 14 Business Days
 
MCAM Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 95 % SDS
Catalog No. ABIN5855057
-15% Promotion 2026
$496.93
$584.62
save $87.69 (-15 %)
Plus shipping costs $50.00, if applicable $20.00 dry ice
50 μg (More quantities available)
Shipping to: United States
Delivery in 13 to 16 Business Days
 
MCAM Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining. ScA, ADA, IA, AM
Catalog No. ABIN7490860
-15% Promotion 2026
$519.89
$611.63
save $91.74 (-15 %)
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 12 to 14 Business Days
 
MCAM Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7505436
-15% Promotion 2026
$195.43
$229.92
save $34.49 (-15 %)
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 11 to 14 Business Days
 
MCAM Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7505192
-15% Promotion 2026
$195.43
$229.92
save $34.49 (-15 %)
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 11 to 14 Business Days
 
MCAM Origin: Rat Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7505548
-15% Promotion 2026
$195.43
$229.92
save $34.49 (-15 %)
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 11 to 14 Business Days
 
MCAM Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN7505639
-15% Promotion 2026
$416.98
$490.56
save $73.58 (-15 %)
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 11 to 14 Business Days
 
MCAM Origin: Human Host: Mammalian Cells Recombinant >90 % as determined by SDS-PAGE. SDS, WB, Imm, ELISA, AcA Active
Catalog No. ABIN7678514
-15% Promotion 2026
$510.63
$600.74
save $90.11 (-15 %)
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 12 to 14 Business Days
 
MCAM Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % SDS, WB, Imm, PC
Catalog No. ABIN7394561
-15% Promotion 2026
$559.01
$657.66
save $98.65 (-15 %)
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 13 to 16 Business Days
 
MCAM Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % SDS, WB, Imm, PC
Catalog No. ABIN7394564
-15% Promotion 2026
$627.11
$737.78
save $110.67 (-15 %)
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 13 to 16 Business Days
 
MCAM Origin: Human Host: Wheat germ Recombinant AP
Catalog No. ABIN1330310
-15% Promotion 2026
$698.57
$821.85
save $123.28 (-15 %)
Plus shipping costs $50.00, if applicable $20.00 dry ice
10 μg
Shipping to: United States
Delivery in 11 to 12 Business Days
 
MCAM Origin: Rat Host: Escherichia coli (E. coli) Recombinant > 90 % SDS, WB, Imm, PC
Catalog No. ABIN7417588
-15% Promotion 2026
$692.66
$814.90
save $122.24 (-15 %)
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Delivery in 13 to 16 Business Days
 
MCAM Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % Inactive
Catalog No. ABIN7669288
-15% Promotion 2026
$1,813.56
$2,133.60
save $320.04 (-15 %)
Plus shipping costs $50.00
500 μg
Shipping to: United States
Delivery in 11 to 14 Business Days
 
MCAM Origin: Rat Host: Escherichia coli (E. coli) Recombinant > 95 % Inactive
Catalog No. ABIN7669286
-15% Promotion 2026
$1,813.56
$2,133.60
save $320.04 (-15 %)
Plus shipping costs $50.00
500 μg
Shipping to: United States
Delivery in 11 to 14 Business Days
 
MCAM Origin: Human Host: HEK-293 Cells Recombinant > 95 % Inactive
Catalog No. ABIN7669285
-15% Promotion 2026
$1,813.56
$2,133.60
save $320.04 (-15 %)
Plus shipping costs $50.00
500 μg
Shipping to: United States
Delivery in 11 to 14 Business Days
 
MCAM Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % Inactive
Catalog No. ABIN7669287
-15% Promotion 2026
$1,813.56
$2,133.60
save $320.04 (-15 %)
Plus shipping costs $50.00
500 μg
Shipping to: United States
Delivery in 11 to 14 Business Days
 
MCAM Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Catalog No. ABIN5712730
$488.40
Plus shipping costs $50.00
100 μg (More quantities available)
Shipping to: United States
Will be delivered in 11 Business Days
 
  • Type Protein
    • Protein
  • Application
    • SDS-PAGE (SDS)
    • Western Blotting (WB)
    • ELISA
    • Immunogen (Imm)
    • Positive Control (PC)
    • Affinity Purification (AP)
    • Activity Assay (AcA)
    • Antibody Array (AA)
    • Antibody Production (AbP)
    • Protein Interaction (PI)
    • Standard (STD)
  • Reactivity
    • Human
    • Mouse
    • Rat
  • Cited in publications
  • Images available
  • Carrier free only
  • Host
    • Escherichia coli (E. coli)
    • HEK-293 Cells
    • Bacteria
    • Wheat germ
    • Baculovirus infected Insect Cells
    • HEK-293T Cells
    • Mammalian Cells
    • Yeast
  • Binding Specificity
    • AA 24-559
    • AA 1-559
    • AA 324-565
    • AA 1-646
    • AA 151-350
    • AA 224-464
    • AA 24-560
    • AA 24-563
    • AA 24-646
    • AA 25-206
    • AA 323-560
    • AA 341-563
    • AA 36-245
    • AA 50-646
    • partial
  • Conjugate
    • His tag
    • GST tag
    • His-DYKDDDDK-Strep II Tag
    • Myc-DYKDDDDK Tag
    • Un-conjugated
  • Protein Type
    • Recombinant
  • Format
    • Lyophilized
    • Liquid
  • Biological Activity
    • Biologically Inactive
    • Biologically Active
  • Supplier
    • antibodies-online
    • ProteoGenix
    • CUSABIO
    • OriGene
    • Signalway

Latest Publications for our MCAM Proteins

Gao, Zhang, Wang, Liu, He, Liu, Wang, Feng, Yang, Wang, Meng, Yan: "The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis." in: Nature communications, Vol. 8, pp. 15279, (2018) (PubMed).

Luo, Duan, Qian, Feng, Wu, Wang, Feng, Yang, Qin, Yan: "Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis." in: Cell research, Vol. 27, Issue 3, pp. 352-372, (2017) (PubMed).

Tu, Zhang, Yan, Luo, Kong, Wen, Ye, Chen, Feng, Liu, Wu, Yan: "CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development." in: Cell research, Vol. 25, Issue 3, pp. 275-87, (2015) (PubMed).

Keller, Kalt, Raab, Schachner, Mayrhofer, Kerjaschki, Hantusch: "Selection of scFv Antibody Fragments Binding to Human Blood versus Lymphatic Endothelial Surface Antigens by Direct Cell Phage Display." in: PLoS ONE, Vol. 10, Issue 5, pp. e0127169, (2015) (PubMed).

Ishikawa, Wondimu, Oikawa, Ingerpuu, Virtanen, Patarroyo: "Monoclonal antibodies to human laminin ?4 chain globular domain inhibit tumor cell adhesion and migration on laminins 411 and 421, and binding of ?6?1 integrin and MCAM to ?4-laminins." in: Matrix biology : journal of the International Society for Matrix Biology, Vol. 36, pp. 5-14, (2014) (PubMed).

Ye, Zhang, Tu, Sun, Liu, Lu, Feng, Yang, Liu, Yan: "Wnt5a uses CD146 as a receptor to regulate cell motility and convergent extension." in: Nature communications, Vol. 4, pp. 2803, (2013) (PubMed).

Simon, Martin, Smith, Thaikoottathil, Bowler, Barenkamp, Chu: "Up-regulation of MUC18 in airway epithelial cells by IL-13: implications in bacterial adherence." in: American journal of respiratory cell and molecular biology, Vol. 44, Issue 5, pp. 606-13, (2011) (PubMed).

Aliases for MCAM Proteins

melanoma cell adhesion molecule (MCAM) Proteins
melanoma cell adhesion molecule (Mcam) Proteins
melanoma cell adhesion molecule b (mcamb) Proteins
1-gicerin Proteins
AV025631 Proteins
CD146 Proteins
cd146 Proteins
CD149 Proteins
gicerin Proteins
id:ibd3512 Proteins
mcam Proteins
MCAM Proteins
MUC18 Proteins
Muc18 Proteins
s-endo Proteins
s-gicerin Proteins
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