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METAP2 Products

(Methionyl Aminopeptidase 2 (METAP2))

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This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2. [provided by RefSeq, Jul 2008].

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Featured METAP2 Categories

METAP2 Antibodies

High quality antibodies with extensive validation data.

METAP2 ELISA Kits

Reliable ELISA kits for a wide range of species.

METAP2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended METAP2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application FACS, IF, IHC, IHC (p), WB
Validations
  • (11)
Cat. No. ABIN1491153
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IF, IHC, WB
Validations
  • (3)
Cat. No. ABIN7159581
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application IF, WB
Validations
  • (3)
Cat. No. ABIN524383
Quantity 50 μg
Datasheet Datasheet

Recommended METAP2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Competition ELISA
Validations
  • (1)
Cat. No. ABIN6968594
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6957795
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6957796
Quantity 96 tests
Datasheet Datasheet

Recommended METAP2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Baculovirus infected Insect Cells
Validations
  • (1)
Cat. No. ABIN7197008
Quantity 20 μg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3131274
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3093754
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our METAP2 products

Datta, Tammali, Datta: "Negative regulation of the protection of eIF2alpha phosphorylation activity by a unique acidic domain present at the N-terminus of p67." in: Experimental cell research, Vol. 283, Issue 2, pp. 237-46, (2003) (PubMed).

Wang, Sheppard, Lou, Kawai, Park, Egan, Schneider, Bouska, Lesniewski, Henkin: "Physiologically relevant metal cofactor for methionine aminopeptidase-2 is manganese." in: Biochemistry, Vol. 42, Issue 17, pp. 5035-42, (2003) (PubMed).

Endo, Takenaga, Kanno, Satoh, Mori: "Methionine aminopeptidase 2 is a new target for the metastasis-associated protein, S100A4." in: The Journal of biological chemistry, Vol. 277, Issue 29, pp. 26396-402, (2002) (PubMed).

Synonyms and alternative names related to METAP2

methionyl aminopeptidase 2 L homeolog (metap2.L), methionyl aminopeptidase 2 (METAP2), methionyl aminopeptidase 2 (metap2), methionine aminopeptidase 2 (LOC551771), methionine aminopeptidase 2 (metap2), methionine aminopeptidase (CAALFM_C604080WA), methionine aminopeptidase 2 (Metap2), methionyl aminopeptidase 2 S homeolog (metap2.S), methionyl aminopeptidase 2 (Metap2), methionyl aminopeptidase 2b (metap2b), 4930584B20Rik, A930035J23Rik, AI047573, AL024412, Amp2, AU014659, DDBDRAFT_0190923, DDBDRAFT_0304991, DDB_0190923, DDB_0304991, GB13458, MAP2, metap2, METAP2, MGC53792, Mnpep, MNPEP, p67, p67eIF2, wu:fb98h06, zgc:66250

Protein level used designations for METAP2

  • methionine aminopeptidase 2
  • methionyl aminopeptidase 2
  • methionine aminopeptidase 2-like
  • hypothetical protein
  • MAP 2
  • eIF-2-associated p67
  • initiation factor 2-associated 67 kDa glycoprotein
  • initiation factor 2-associated protein (p67)
  • metAP 2
  • peptidase M 2
  • eIF-2-associated p67 homolog
  • initiation factor 2 associated 67 kDa protein
  • p67eIF2
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