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anti-Human RHOA Antibodies:
anti-Mouse (Murine) RHOA Antibodies:
anti-Rat (Rattus) RHOA Antibodies:
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PCGEM1 may be an inducer in epithelial ovarian cancer tumorigenesis and progression by upregulating RhoA and the subsequent expression of YAP (show YAP1 Antibodies), P70S6K (show RPS6KB1 Antibodies), MMP2 (show MMP2 Antibodies), and Bcl-xL (show BCL2L1 Antibodies).
This study identified Piezo2 (show FAM38B Antibodies) mechanosensitive cationic channel as a transducer of environmental physical cues into mechanobiological responses.
High RHOA expression is associated with gastric cancer invasion and metastasis.
Results show that RHOA expression level is under the regulation of NORAD to promote EMT (show ITK Antibodies) in pancreatic neoplasm.
Data show that phosphorylation of ribosomal protein S6 kinase 2 (RSK2 (show RPS6KA3 Antibodies)) at threonine 577 is essential for leukemia-associated RhoGEF (LARG (show ARHGEF12 Antibodies))-dependent Rho GTPase (show RACGAP1 Antibodies) activation.
RhoA activated the downstream Wnt/betacatenin signaling pathway and inhibited the expression of apoptotic factors.
We identify HGF (show HGF Antibodies), acting through the c-Met receptor, as the key polarity-inducing morphogen (show SHH Antibodies), which acts to activate b1-integrin-dependent adhesion. HGF (show HGF Antibodies) and ECM (show MMRN1 Antibodies)-derived integrin signals co-operate via a c-Src (show SRC Antibodies)-dependent inhibition of the RhoA-ROCK1 (show ROCK1 Antibodies) signalling pathway via p190A (show GRLF1 Antibodies) RhoGAP (show ARHGAP1 Antibodies)
Extracellular Hsp90alpha mediates house dust mite-induced human bronchial epithelial barrier dysfunction by activating RhoA/MLC signaling, suggesting that eHsp90alpha is a potential therapeutic target for treatment of asthma.
This analysis showed a relative increase in the expression of E2F6 (show E2F6 Antibodies) in gastric adenocarcinoma with no lymph node metastasis (chi (2), P = 0.04 and OR, P = 0.08), while overexpression of RhoA and SMUG1 (show SMUG1 Antibodies) was found more often in the diffuse subtype of gastric adenocarcinoma as compared to the intestinal subtype.
This is the first study to verify the relationship of the expression of RhoA and Ezrin (show EZR Antibodies) proteins in vaginal tissue of Postmenopausal atrophic vagina.
Non-visual arrestins regulate the focal adhesion formation via small GTPases RhoA and Rac1 independently of G-protein-coupled receptors.
RHOA loss reduces YAP (show YAP1 Antibodies) signaling of the Hippo pathway and affects YAP (show YAP1 Antibodies) effector epiregulin (EREG (show EREG Antibodies)) expression in the crypts. Expression of an active YAP (show YAP1 Antibodies) (S112A) mutant rescues ntestinal stem cells (ISCs (show NFS1 Antibodies)) marker expression, ISC regeneration, and ISC-associated Wnt (show WNT2 Antibodies) signaling, but not defective epithelial polarity, in RhoA knockout mice, implicating YAP (show YAP1 Antibodies) in RHOA-regulated ISC function.
GTP (show AK3 Antibodies)-RhoA and ROCK1 (show ROCK1 Antibodies) expression levels were markedly increased in a time-dependent manner in the ears and lungs of mice treated with penicillin.
Tyr42 phosphorylation of RhoA GTPase promotes tumorigenesis through NF-kappaB (show NFKB1 Antibodies).
RhoA modulates the choices of molar cuspal shape by coordinating adhesion junctions, actin distribution, and fibronectin (show FN1 Antibodies) localization to drive inner dental epithelium invagination.
Kctd13 deletion reduces synaptic transmission, which correlates with increased levels of RhoA, a KCTD13/CUL3 ubiquitin ligase substrate
Crmp4(-/-) OBs exhibited enhanced activation of RhoA/focal adhesion kinase (FAK) signaling that led to cytoskeletal changes with increased cell spreading.
Codepletion of the actomyosin regulator RhoA and Afadin (show MLLT4 Antibodies) results in defects in the central lumens and arrests lumen remodeling
Hydrogen peroxide oxidizes RhoA at Cys16 and Cys20, and activates RhoA via Vav2 (show VAV2 Antibodies).
These results reveal a novel signaling network, the Sema4D (show SEMA4D Antibodies)-RhoA-Akt (show AKT1 Antibodies) signal cascade, that coordinates cellular function and morphology and highlights the importance of specific spatiotemporally restricted components of a signaling pathway in the regulation of ameloblast differentiation.
Mgc's GAP activity down-regulates the active populations of RhoA and Rac1 at localized regions of epithelial cells and is necessary for successful cytokinesis and cell-cell junction structure
Data show that shortly after anaphase onset oocytes and embryonic cells exhibit cortical waves of Rho activity and F-actin polymerization.
CASZ1 (show CASZ1 Antibodies)/Egfl7 (show EGFL7 Antibodies)/RhoA pathway is necessary for promoting endothelial cell behaviors associated with proper vascular assembly.
RhoA can be considered a component of the intracellular pattern formation system.
Kazrin (show KAZ Antibodies) interacts with ARVCF (show ARVCF Antibodies)-catenin, spectrin and p190B (show ARHGAP5 Antibodies) RhoGAP (show ARHGAP1 Antibodies), and modulates RhoA activity.
Morphogenesis of the primitive gut tube is generated by Rho/ROCK/myosin II-mediated endoderm rearrangements.
RhoA and membrane fluidity mediates the spatially polarized Src (show SRC Antibodies)/FAK (show PTK2 Antibodies) activation in response to shear stress.
the Lbc (show AKAP13 Antibodies)/alpha-catulin (show CTNNAL1 Antibodies) axis participates in 5-HT (show DDC Antibodies)-induced PASMC mitogenesis and RhoA/ROCK signaling, and may be an interventional target in diseases involving vascular smooth muscle remodeling.
The RhoA/ROCK signaling pathway is an important negative regulator of vascular calcification.
Vascular endothelial-cadherin signals through RhoA and actin cytoskeletal and affects cell-matrix adhesion
Thrombospondin has a role in inducing RhoA inactivation through FAK (show PTK2 Antibodies)-dependent signaling to stimulate focal adhesion disassembly
KCl directly increased Rho and ROCK activities in a concentration-dependent fashion that paralleled closely the effect of KCl on lung smooth muscle tone and [Ca(2 (show CA2 Antibodies)+)](i), as well as the voltage-dependent Ca(2 (show CA2 Antibodies)+) currents
the Rho-ROCK signal pathway contributes to VEGF (show VEGFA Antibodies)-induced hyperpermeability. Myosin light-chain phosphorylation and actin stress fiber formation occur concomitantly with the increase in permeability upon VEGF (show VEGFA Antibodies) stimulation.
Formation of polygonal actin network in endothelial cells is a novel rhoA associated response to hypertonic stress.
Cadherins, RhoA and Rac1, have important roles in mechanotransduction and that endothelial and smooth muscle cells use different mechanisms to respond to stretch.
Results indicate that hypergravity induces ATP release and actin reorganization via RhoA activation and FAK (show PTK2 Antibodies) phosphorylation, thereby activating cell proliferation and migration in bovine aortic endothelial cells.
Pseudorabies virus US3 expression led to RhoA phosphorylation at serine 188 to induce actin rearrangements.
Data indicate that TNF-alpha (show TNF Antibodies) stimulates Rac (show AKT1 Antibodies), ADAM17/TACE (show ADAM17 Antibodies), and RhoA through the guanine nucleotide exchange factor (show ARHGEF12 Antibodies) (GEF)-H1 (show ARHGEF2 Antibodies).
Contractile pulmonary arterial myocytes exhibit marked Rho-dependent actin polymerization in hypoxia, with increased active RhoA and LIMK (show LIMK1 Antibodies) phosphorylation.
Results suggest that Rac1 and RhoA are regulated by TGFbeta1 (show TGFB1 Antibodies) in the process of endothelial tube formation in collagen I gels.
The concentration of RhoA mRNA and activated RhoA enzyme were greater in urothelium than in detrusor. Rho kinase (show ROCK1 Antibodies) inhibitor Y-27632 showed a stronger inhibitory effect in detrusor with intact urothelium.
Thrombin (show F2 Antibodies) stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1 (show F2R Antibodies), RhoA, and myocardin (show MYOCD Antibodies).
Activating Rho could be beneficial to suppress Kras mutant-induced liver malignancies.
Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton.
Aplysia ras-related homolog 12
, oncogene RHO H12
, ras homolog gene family, member A
, rho cDNA clone 12
, small GTP binding protein RhoA
, transforming protein RhoA
, Rho-related protein HP1
, ras homolog D
, ras homolog gene family, member D
, rho-related GTP-binding protein RhoD
, Ras family member A
, Rho family GTPase
, aplysia ras-related homolog A
, aplysia ras-related homolog A1
, aplysia ras-related homolog A2
, ras homolog A1
, ras homolog A2
, ras homolog gene family, member A1
, ras homolog gene family, member A2
, plysia ras-related homolog A2
, rho1 GTP-binding protein
, RhoA GTPase
, Rho A