MLL1 Products
(Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1))
Categories
Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis (By similarity).
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Featured MLL1 Categories
MLL1 Antibodies
High quality antibodies with extensive validation data.
MLL1 ELISA Kits
Reliable ELISA kits for a wide range of species.
Recommended MLL1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IP
Validations
Cat. No.
ABIN7452651
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP, ChIP
Validations
Cat. No.
ABIN7449154
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
Cat. No.
ABIN7450452
Quantity
100 μg
Datasheet
Datasheet
Recommended MLL1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Dog
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN1503540
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Monkey
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN1503541
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Pig
Analytical Method
Validations
Cat. No.
ABIN1503539
Quantity
96 tests
Datasheet
Datasheet
Synonyms and alternative names related to MLL1
lysine methyltransferase 2A (Kmt2a), lysine (K)-specific methyltransferase 2A (Kmt2a), 6430520K01, ALL-1, All1, Cxxc7, HRX, HTRX1, mKIAA4050, Mll, Mll1Protein level used designations for MLL1
- Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene)
- histone-lysine N-methyltransferase MLL
- myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
- myeloid/lymphoid or mixed-lineage leukemia 1
- histone-lysine N-methyltransferase 2A
- lysine N-methyltransferase 2A
- myeloid/lymphoid or mixed-lineage leukemia protein 1
- trithorax Drosophila
- zinc finger protein HRX
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