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Due to enoyl coenzyme A hydratase, short chain, 1, mitochondria (ECHS1) deficiency.
exceeding nutrients suppress Enoyl-CoA hydratase-1 (ECHS1) activity by inducing its acetylation resulting in accumulation of fatty acids and branched-chain amino acids and oncogenic mTOR (show FRAP1 Proteins) activation
ECHS1 mutations phenotype might be milder than reported earlier, compatible with prolonged survival, and also includes isolated paroxysmal exercise-induced dystonia.
Whole exome sequencing identified heterozygous ECHS1 mutations c.836T>C (novel) and c.8C>A for short-chain enoyl-CoA hydratase (SCEH) deficiency of which 1/2 of the cases are associated with secondary lymphocyte pyruvate dehydrogenase (show PDP Proteins) complex deficiency.[review]
This is the first report of homozygosity for a truncating mutation in ECHS1, which may explain the severe phenotype. Our report highlights the need to consider SCEH deficiency in patients with lethal neonatal lactic acidosis
Human ECHS1 catalyses the hydration of five substrates via different metabolic pathways, with the highest specificity for crotonyl-CoA and the lowest specificity for tiglyl-CoA
These results suggested that ECHS1 may promote cell proliferation in hepatocellular carcinoma in an EGFR (show EGFR Proteins)-dependent manner.
In conclusion, the results of the present study suggested that ECHS1 may have an important role in colorectal cancer cell proliferation and migration
identification of four additional patients with mutations in ECHS1 highlights the importance of the valine degradation pathway in Leigh syndrome
ECHS1 mutations cause combined respiratory chain deficiency resulting in Leigh syndrome.
potential protein targets for the loss of PostC may include F(1)-ATPase gamma, Echs1 and Hsp20 (show HSPB6 Proteins) that could regulate cellular ATP consumption/production and defense response to ischaemic stress
The protein encoded by this gene functions in the second step of the mitochondrial fatty acid beta-oxidation pathway. It catalyzes the hydration of 2-trans-enoyl-coenzyme A (CoA) intermediates to L-3-hydroxyacyl-CoAs. The gene product is a member of the hydratase/isomerase superfamily. It localizes to the mitochondrial matrix. Transcript variants utilizing alternative transcription initiation sites have been described in the literature.
enoyl Coenzyme A hydratase, short chain, 1, mitochondrial
, enoyl-CoA hydratase 1
, enoyl-CoA hydratase, mitochondrial
, short-chain enoyl-CoA hydratase
, short chain enoyl-CoA hydratase
, Enoyl-CoA hydratase short chain 1 mitochondrial
, Enoyl-CoA hydratase, short chain 1, mitochondrial
, enoyl Coenzyme A hydratase, short chain 1
, mitochondrial short-chain enoyl-coenzyme A hydratase 1