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cloning and expression analysis of a protein kinase C gene, PKCmu, and its regulation of the promoter region (PKCmu)
PKD1 (show PKD1 Proteins) contributes to the regulation of physiological angiogenesis and lymphangiogenesis during zebrafish development and is essential for tumor angiogenesis.
these results describe a novel mechanism governing PRKD1 gene expression in pancreatic ductal adenocarcinoma and provide a functional link between oncogenic KRas, NF-kappaB (show NFKB1 Proteins) and expression of PRKD1.
p110alpha (show PIK3CA Proteins) subunit of PI3K (show PIK3CA Proteins) and PKD mediate YAP (show YAP1 Proteins) activation in response to insulin (show INS Proteins) and neurotensin (show NTS Proteins) in pancreatic cancer cells. Inhibitors of PI3K (show PIK3CA Proteins) or PKD disrupt crosstalk between insulin receptor (show INSR Proteins) and GPCR (show NMUR1 Proteins) signaling systems by blocking YAP (show YAP1 Proteins)/TEAD-regulated gene expression in pancreatic cancer cells
High PRKD1 expression is associated with drug resistance in breast cancer.
Our findings directly associate the AR/NCOA1 (show NCOA1 Proteins) complex with PRKD1 regulation and cellular migration and support the concept of therapeutic inhibition of NCOA1 (show NCOA1 Proteins) in prostate cancer.
None of the Polymorphous low-grade adenocarcinoma (PLGA) lacking PRKD1 somatic mutations or PRKD gene family rearrangements harboured somatic mutations in the kinase domains of the PRKD2 (show PKD2 Proteins) or PRKD3 (show PRKD3 Proteins) genes.
A single nucleotide polymorphism located within the fourth intron of PRKD1 (rs57803087) was strongly associated with DPP-4 (show DPP4 Proteins) inhibitor response in patients with type 2 diabetes
Mutation in PRKD1 gene is associated with congenital heart defects.
Bradykinin stimulates myofibroblast migration through protein kinase D-mediated activation of COX-2 and Hsp27 (show HSPB1 Proteins).
Lysophosphatidic acid/PKD-1 (show PKD1 Proteins) signaling leads to nuclear accumulation of histone deacetylase 7 (show HDAC7 Proteins), where it interacts with forkhead box protein O1 (show FOXO1 Proteins) to suppress endothelial CD36 (show CD36 Proteins) transcription and mediates silencing of antiangiogenic switch, resulting in proangiogenic and proarteriogenic reprogramming.
This study discovered and characterized a novel, highly conserved N-terminal domain, comprising 92 amino acids, which mediates dimerization of Protein Kinase D (PKD) isoforms, PKD1 (show PKD1 Proteins), PKD2 (show PKD2 Proteins), and PKD3 (show PRKD3 Proteins) monomers.
The study demonstrates an essential role for PKD1 (show PKD1 Proteins) in the beta-cell adaptive secretory response to high-fat feeding in mice.
These findings imply that PKD1 (show PKD1 Proteins) plays a critical regulatory role in Group B streptococci (GBS (show GNB5 Proteins))-induced proinflammatory reactions and sepsis, and inhibition of PKD1 (show PKD1 Proteins) activation together with antibiotic treatment in GBS (show GNB5 Proteins)-infected neonates could be an effective way to control GBS (show GNB5 Proteins) diseases.
Our studies demonstrate that PKD1 (show PKD1 Proteins)/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha (show DGKA Proteins) effect on MVB secretory traffic.
Our results show that AKAP13-PKD1 (show PKD1 Proteins) signaling is critical for transcriptional regulation of key contractile, cell death, and metabolic pathways during the development of compensatory hypertrophy in vivo.
PKD1 (show PKD1 Proteins) acts downstream of TGFalpha and Kras, to mediate formation of ductal structures through activation of the Notch (show NOTCH1 Proteins) pathway.
Results reveal that whereas protein kinase D1 and protein kinase D2 (show PKD2 Proteins) are essential for neuronal polarity, there exists a functional redundancy between the two proteins.
PKD controls synaptic plasticity and learning by regulating actin stability in dendritic spines.
regulatory kinase of eNOS (show NOS3 Proteins) in endothelial cells whose activity orchestrates mammalian vascular tone
Overexpression of constitutively active PKD1 (show PKD1 Proteins) in rodent heart results in dilated cardiomyopathy.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
Data indicate that Ser738/742-to-glutamate (show GRIN2A Proteins) protein kinase D mutant increased AngII-induced CREB (show CREB1 Proteins) protein and activating transcription factor 2 (show ATF2 Proteins) phosphorylation, and phospho-CREB (show CREB1 Proteins) binding to the steroidogenic acute regulatory protein (show STAR Proteins) promoter.
These results indicate that PKD is downstream of PLD and suggest that PKD is one of the mechanisms through which PLD promotes aldosterone production in response to AngII in adrenal glomerulosa cells.
PKD mediates acute AngII-induced aldosterone secretion.
Protein kinase D-HDAC5 (show HDAC5 Proteins) pathway plays an important role in VEGF (show VEGFA Proteins) regulation of gene transcription and angiogenesis
PRKD1 is a serine/threonine kinase that regulates a variety of cellular functions, including membrane receptor signaling, transport at the Golgi, protection from oxidative stress at the mitochondria, gene transcription, and regulation of cell shape, motility, and adhesion (summary by Eiseler et al., 2009
protein kinase D1
, protein kinase C, mu
, serine/threonine-protein kinase D1-like
, protein kinase C mu type
, protein kinase D
, serine/threonine-protein kinase D1
, protein kinase C mu