anti-Dog (Canine) ABCC8 antibody for Western Blotting

Recommended ABCC8 Antibody (supplied by: Log in to see )

Antigen
ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) Antibodies
  • ABC36
  • HHF1
  • HI
  • HRINS
  • MRP8
  • PHHI
  • SUR
  • SUR1
  • SUR1delta2
  • TNDM2
  • D930031B21Rik
  • Sur
  • Sur1
  • ATP binding cassette subfamily C member 8
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 8
  • ABCC8
  • Abcc8
Epitope
N-Term
72
67
14
4
4
3
2
2
1
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus), Zebrafish (Danio rerio)
107
98
85
71
3
2
2
1
1
1
1
1
Host
Rabbit
96
28
17
Clonality
Polyclonal
Conjugate
This ABCC8 antibody is un-conjugated
9
9
7
6
5
4
4
3
3
3
3
3
3
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
128
93
65
45
36
21
9
3
2
2
1
1
1
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Catalog No. ABIN2781496
$ 289.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
4.8202314 ABIN2560236 ELISA WB Goat IgG C-Term Log in to see Polyclonal 0
4 ABIN490470 ELISA WB Goat AA 1559-1571 Log in to see Polyclonal 0
1 ABIN5553750 EIA WB Goat C-Term Log in to see Polyclonal 0

General

Antigen ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) Antibodies
Epitope N-Term
(72), (67), (14), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus), Zebrafish (Danio rerio)
(107), (98), (85), (71), (3), (2), (2), (1), (1), (1), (1), (1)
Host Rabbit
(96), (28), (17)
Clonality
Polyclonal
Conjugate This ABCC8 antibody is un-conjugated
(9), (9), (7), (6), (5), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunohistochemistry (IHC), Western Blotting (WB)
(128), (93), (65), (45), (36), (21), (9), (3), (2), (2), (1), (1), (1)
Pubmed 2 references available
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Product Details anti-ABCC8 Antibody

Target Details ABCC8 Application Details Handling References for anti-ABCC8 antibody (ABIN2781496) Images
Blocking Peptide Blocking peptide for this product available: ABIN972735
Sequence PLAFCGSENH SAAYRVDQGV LNNGCFVDAL NVVPHVFLLF ITFPILFIGW
Predicted Reactivity Cow: 100%, Dog: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%
Characteristics This is a rabbit polyclonal antibody against ABCC8. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human ABCC8
Plasmids, Primers & others

Target Details ABCC8

Product Details anti-ABCC8 Antibody Application Details Handling References for anti-ABCC8 antibody (ABIN2781496) Images back to top
Antigen
Alternative Name ABCC8 (ABCC8 Antibody Abstract)
Background ABCC8 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). ABCC8 is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion.The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed, however, the transcript variants have not been fully described. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ABC36, HHF1, HI, HRINS, MRP8, PHHI, SUR, SUR1, TNDM2, SUR1delta2
Protein Interaction Partner: ENSA, KCNJ11, CRYBB1, KCNJ8, RAPGEF4,
Protein Size: 1581
Molecular Weight 177 kDa
Gene ID 6833
NCBI Accession NM_000352, NP_000343
UniProt Q09428
Pathways Negative Regulation of Hormone Secretion

Application Details

Product Details anti-ABCC8 Antibody Target Details ABCC8 Handling References for anti-ABCC8 antibody (ABIN2781496) Images back to top
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 1581 AA

Restrictions For Research Use only

Handling

Product Details anti-ABCC8 Antibody Target Details ABCC8 Application Details References for anti-ABCC8 antibody (ABIN2781496) Images back to top
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-ABCC8 antibody (ABIN2781496)

Product Details anti-ABCC8 Antibody Target Details ABCC8 Application Details Handling Images back to top
Product cited in:

Němcová-Fürstová, Kopperová, Balušíková, Ehrlichová, Brynychová, Václavíková, Daniel, Souček, Kovář: "Characterization of acquired paclitaxel resistance of breast cancer cells and involvement of ABC transporters." in: Toxicology and applied pharmacology, Vol. 310, pp. 215-228, 2016

Background publications

Babenko: "A novel ABCC8 (SUR1)-dependent mechanism of metabolism-excitation uncoupling." in: The Journal of biological chemistry, Vol. 283, Issue 14, pp. 8778-82, 2008

Images

Product Details anti-ABCC8 Antibody Target Details ABCC8 Application Details Handling References for anti-ABCC8 antibody (ABIN2781496) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (N-Term) antibody (ABIN2781496) anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (N-Term) antibody
Western Blotting (WB) image for anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (N-Term) antibody (ABIN2781496) WB Suggested Anti-ABCC8 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Posi...