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|Antigen||Chromogranin A (CHGA) Antibodies|
|Epitope||AA 420-457 Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|5 references available|
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|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human CGA|
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|Alternative Name||Chromogranin A (CHGA Antibody Abstract)|
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides, vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown. [provided by RefSeq, Jul 2008].
Subcellular location: Secreted
Synonyms: CGA, Chromogranin-A, Pituitary secretory protein I, SP-I, CHGA
|Pathways||Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling|
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|Restrictions||For Research Use only|
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|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at -20°C|
|Expiry Date||12 months|
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|Product cited in:||
Liu, Zhang, Zhang, Zhang, Hao, Song, Li, Feng, Hao, Shen, Min, Yang, Zhao: "Regulation of neuroendocrine cells and neuron factors in the ovary by zinc oxide nanoparticles." in: Toxicology letters, Vol. 256, pp. 19-32, 2016 Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Chicken). Further details: Sample: ovary
Liu, Nelson, Cromeens, Rager, Lannutti, Johnson, Besner: "HB-EGF embedded in PGA/PLLA scaffolds via subcritical CO2 augments the production of tissue engineered intestine." in: Biomaterials, Vol. 103, pp. 150-9, 2016 Method employed by authors: Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (Sample species: Rat (Rattus)). Further details: Sample: small intestine
Liu, Rager, Johnson, Enmark, Besner: "Enriched Intestinal Stem Cell Seeding Improves the Architecture of Tissue Engineered Intestine." in: Tissue engineering. Part C, Methods, 2015 Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Rat (Rattus)).
Wang, Ahmad, Sims, Magness, Allbritton: "In vitro generation of colonic epithelium from primary cells guided by microstructures." in: Lab on a chip, Vol. 14, Issue 9, pp. 1622-31, 2014 (Sample species: Mouse (Murine)).
Wang, Ahmad, Shah, Sims, Magness, Allbritton: "Capture and 3D culture of colonic crypts and colonoids in a microarray platform." in: Lab on a chip, Vol. 13, Issue 23, pp. 4625-34, 2013 Method employed by authors: Immunofluorescence (IF) (Sample species: Mouse (Murine)). Further details: Sample: Crypts
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