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|Antigen||Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) Antibodies|
|Epitope||Middle Region Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
Western Blotting (WB)
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|Specificity||NEDD4 L antibody was raised against the middle region of NEDD4|
|Immunogen||NEDD4 L antibody was raised using the middle region of NEDD4 corresponding to a region with amino acids TVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLP|
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|Alternative Name||NEDD4L (NEDD4L Antibody Abstract)|
|Background||NEDD4L is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation.|
|Molecular Weight||110 kDa (MW of target protein)|
|Pathways||Negative Regulation of Transporter Activity|
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WB: 1 µg/mL
Optimal conditions should be determined by the investigator.
NEDD4L Blocking Peptide, catalog no. 33R-9373, is also available for use as a blocking control in assays to test for specificity of this NEDD4L antibody
|Restrictions||For Research Use only|
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|Reconstitution||Lyophilized powder. Add distilled water for a 1 mg/mL concentration of NEDD0 antibody in PBS|
Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.
|Storage Comment||Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.|
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