anti-Dog (Canine) CD40 Ligand antibody for Functional Studies

Recommended CD40 Ligand Antibody (supplied by: Log in to see )

Antigen
CD40 Ligand (CD40LG) Antibodies
  • CD154
  • cd40l
  • CD40L
  • HIGM1
  • IGM
  • IMD3
  • T-BAM
  • TNFSF5
  • TRAP
  • gp39
  • hCD40L
  • CD40-L
  • Cd40l
  • Ly-62
  • Ly62
  • Tnfsf5
  • CD40 ligand
  • TNF superfamily member 5
  • CD40LG
  • cd40l
  • Cd40lg
  • LOC100358388
  • CD154
Reactivity
Dog (Canine), Human
493
252
55
20
20
10
8
8
5
5
4
3
3
3
3
2
2
1
Host
Human
303
175
111
51
45
28
1
1
Antibody Type
Recombinant Antibody
Clonality
Monoclonal
Conjugate
This CD40 Ligand antibody is un-conjugated
75
61
46
17
17
15
15
11
9
9
9
9
9
9
9
8
8
7
7
7
7
6
4
4
4
2
2
2
2
2
2
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Functional Studies (Func), Western Blotting (WB)
434
297
173
109
68
64
51
42
34
20
17
17
13
13
9
9
6
5
4
4
2
2
2
1
1
1
1
1
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Catalog No. ABIN5564228
$ 435.75
Plus shipping costs $45.00

General

Antigen CD40 Ligand (CD40LG) Antibodies
Reactivity Dog (Canine), Human
(493), (252), (55), (20), (20), (10), (8), (8), (5), (5), (4), (3), (3), (3), (3), (2), (2), (1)
Host Human
(303), (175), (111), (51), (45), (28), (1), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CD40 Ligand antibody is un-conjugated
(75), (61), (46), (17), (17), (15), (15), (11), (9), (9), (9), (9), (9), (9), (9), (8), (8), (7), (7), (7), (7), (6), (4), (4), (4), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Application Flow Cytometry (FACS), Functional Studies (Func), Western Blotting (WB)
(434), (297), (173), (109), (68), (64), (51), (42), (34), (20), (17), (17), (13), (13), (9), (9), (6), (5), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1)
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Product Details anti-CD40 Ligand Antibody

Target Details CD40 Ligand Application Details Handling Images
Specificity Recognizes and binds human CD40L with an IC50 of 0.845 μg/mL.
Cross-Reactivity Dog (Canine), Human
Cross-Reactivity (Details) Cross-reacts with canine CD40L.
Purity >95 % (SDS-PAGE)
Endotoxin Level <0.001EU/μg
Immunogen Recombinant human CD40L.
Clone Hu5c8
Isotype IgG1

Target Details CD40 Ligand

Product Details anti-CD40 Ligand Antibody Application Details Handling Images back to top
Antigen
Alternative Name CD40L (CD40LG Antibody Abstract)
Background CD40 Ligand (CD40L), renamed TNFSF5 but now also known as CD154, TRAP and gp39, is a 34-39 kDa type II transmembrane glycoprotein, that belongs to the TNF superfamily, and a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. CD40L binds to CD40, which is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells. CD40L levels are increased in serum and in inflamed tissues of patients with autoimmune diseases.
UniProt P29965
Research Area Adaptive Immunity, Atherosclerosis, CD Antigens, Cytokines, Immunology, Innate Immunity, Surface Receptors of Immune Cells
Pathways NF-kappaB Signaling, Production of Molecular Mediator of Immune Response

Application Details

Product Details anti-CD40 Ligand Antibody Target Details CD40 Ligand Handling Images back to top
Comment

This antibody is a biosimilar called Ruplizumab (Antova, BG9588) and originally developed by Biogen. Ruplizumab is a CD40 ligand blocker designed for the treatment of rheumatic diseases like systemic lupus erythematosus and lupus nephritis, but withdrawn from clinical trials due to side effects.

Restrictions For Research Use only

Handling

Product Details anti-CD40 Ligand Antibody Target Details CD40 Ligand Application Details Images back to top
Format Liquid
Concentration 1 mg/mL
Buffer In PBS.
Preservative Without preservative
Storage 4 °C,-20 °C
Storage Comment Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 3 months after receipt when stored at +4°C.
Expiry Date 12 months