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|Antigen||CD40 Ligand (CD40LG) Antibodies|
|Conjugate||This CD40 Ligand antibody is un-conjugated Alternatives|
Blocking Antibody (Inhibition), ELISA, Western Blotting (WB)
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Product Details anti-CD40 Ligand AntibodyTarget Details CD40 Ligand Application Details Handling Images
|Immunogen||CD40 L antibody was raised in goat using highly pure recombinant human sCD40 as the immunogen.|
|Plasmids, Primers & others|
Target Details CD40 LigandProduct Details anti-CD40 Ligand Antibody Application Details Handling Images back to top
|Alternative Name||CD40L (CD40LG Antibody Abstract)|
|Background||CD40, a member of the TNF receptor family, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40-Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to immunodeficiency with hyper-IgM, a disease characterized by failure to produce IgG, IgA and IgE. The human CD40L gene codes for a 261 amino acid type II transmembrane protein, which contains a 22 amino acid cytoplasmic domain, a 24 amino acid transmembrane domain, and a 215 amino acid extracellular domain.|
|Molecular Weight||16.3 kDa (predicted detection band MW)|
|Pathways||NF-kappaB Signaling, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints|
Application DetailsProduct Details anti-CD40 Ligand Antibody Target Details CD40 Ligand Handling Images back to top
|Application Notes||Optimal conditions should be determined byt he investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-CD40 Ligand Antibody Target Details CD40 Ligand Application Details Images back to top
|Buffer||Lyophilized from PBS, pH 7.2.|
Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.
|Storage Comment||Store at -20 °C until reconstitution. Following reconstitution product may be stored at 4 °C in the short term. For long term storage aliquot and freeze at -20 °C.|