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|Antigen||Epidermal Growth Factor Receptor (EGFR) Antibodies|
|Conjugate||This EGFR antibody is un-conjugated Alternatives|
Immunochromatography (IC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
|6 references available|
|Supplier||Log in to see|
Product Details anti-EGFR AntibodyTarget Details EGFR Application Details Handling References for anti-EGFR antibody (ABIN285476) Images
|Cross-Reactivity||Mouse (Murine), Rat (Rattus), Turkey|
|Immunogen||EGFR antibody was raised in sheep using a synthetic 20 amino acid peptide of human EGFr representing a portion of the internal domain proximal to a phosphorylation region as the immunogen.|
|Plasmids, Primers & others|
Target Details EGFRProduct Details anti-EGFR Antibody Application Details Handling References for anti-EGFR antibody (ABIN285476) Images back to top
|Alternative Name||EGFR (EGFR Antibody Abstract)|
|Background||The epidermal growth factor receptor (EGFR) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. EGFR (epidermal growth factor receptor) exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor alpha (TGF alpha).|
|Pathways||NF-kappaB Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation|
Application DetailsProduct Details anti-EGFR Antibody Target Details EGFR Handling References for anti-EGFR antibody (ABIN285476) Images back to top
WB: 10-50 µg/mL, IC: 25-100 µg/mL, IHC-P: 5 µg/mL, IP: 10-12 µg/mL, WB: 10-50 µg/mL
Optimal conditions should be determined by the investigator.
|Restrictions||For Research Use only|
HandlingProduct Details anti-EGFR Antibody Target Details EGFR Application Details References for anti-EGFR antibody (ABIN285476) Images back to top
|Buffer||Protein G purified and supplied in PBS, pH 7.2.|
Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.
|Storage Comment||Aliquot and store at -20 °C.|
References for anti-EGFR antibody (ABIN285476)Product Details anti-EGFR Antibody Target Details EGFR Application Details Handling Images back to top
|Product cited in:||
Matsui, Noguchi, Fukuda: "Dennd3 functions as a guanine nucleotide exchange factor for small GTPase Rab12 in mouse embryonic fibroblasts." in: The Journal of biological chemistry, Vol. 289, Issue 20, pp. 13986-95, 2014
Rønning, Pedersen, Madshus, Stang: "CIN85 regulates ubiquitination and degradative endosomal sorting of the EGF receptor." in: Experimental cell research, Vol. 317, Issue 13, pp. 1804-16, 2011
Larsen, Stockhausen, Poulsen: "Cell adhesion and EGFR activation regulate EphA2 expression in cancer." in: Cellular signalling, Vol. 22, Issue 4, pp. 636-44, 2010
Grøvdal, Johannessen, Rødland, Madshus, Stang: "Dysregulation of Ack1 inhibits down-regulation of the EGF receptor." in: Experimental cell research, Vol. 314, Issue 6, pp. 1292-300, 2008
Bertelsen, Breen, Sandvig, Stang, Madshus: "The Cbl-interacting protein TULA inhibits dynamin-dependent endocytosis." in: Experimental cell research, Vol. 313, Issue 8, pp. 1696-709, 2007
Oksvold, Huitfeldt, Langdon: "Identification of 14-3-3zeta as an EGF receptor interacting protein." in: FEBS letters, Vol. 569, Issue 1-3, pp. 207-10, 2004
ImagesProduct Details anti-EGFR Antibody Target Details EGFR Application Details Handling References for anti-EGFR antibody (ABIN285476) back to top