anti-Human EGFR antibody for Immunohistochemistry (Formalin-fixed Sections)

Recommended EGFR Antibody (supplied by: Log in to see )

Antigen
Epidermal Growth Factor Receptor (EGFR) Antibodies
  • C-erb
  • CG10079
  • D-EGFR
  • D-Egf
  • DEGFR
  • DER
  • DER flb
  • DER/EGFR
  • DER/faint little ball
  • DER/top
  • DER/torpedo
  • DER1
  • DEgfr
  • Degfr
  • Der
  • DmHD-33
  • Dmel\\CG10079
  • EFG-R
  • EGF-R
  • EGFR
  • EGFr
  • EGfr
  • EK2-6
  • Egf
  • Egf-r
  • EgfR
  • El
  • Elp
  • Elp-1
  • Elp-B1
  • Elp-B1RB1
  • HD-33
  • TOP
  • Torpedo/DER
  • Torpedo/Egfr
  • c-erbB
  • d-egf-r
  • dEGFR
  • dEGFR1
  • dEgfr
  • der
  • egfr
  • flb
  • l(2)05351
  • l(2)09261
  • l(2)57DEFa
  • l(2)57EFa
  • l(2)57Ea
  • mor1
  • top
  • top/DER
  • top/flb
  • torpedo/Egfr
  • torpedo/egfr
  • EGFR12
  • EGFR15
  • egfr1
  • Erbb2
  • ERBB
  • ERBB1
  • HER1
  • PIG61
  • mENA
  • ErbB-1
  • Errp
  • 9030024J15Rik
  • AI552599
  • Erbb
  • Errb1
  • Wa5
  • wa-2
  • wa2
  • epidermal growth factor receptor
  • Epidermal growth factor receptor
  • epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
  • EGFR
  • Egfr
  • egfra
  • egfr1
  • LOC5564544
Epitope
Extracellular Domain
161
126
66
65
60
59
56
54
53
50
50
48
42
40
39
35
32
31
31
30
28
27
26
24
22
19
18
18
18
17
17
17
17
17
16
16
16
15
15
15
15
15
15
15
11
9
8
8
8
7
6
6
6
6
6
5
5
5
5
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Horse (Equine)
2658
911
742
27
25
18
17
14
11
7
2
2
2
1
1
1
1
Host
Mouse
1545
1004
84
44
12
5
2
1
1
Clonality
Monoclonal
Conjugate
This EGFR antibody is conjugated to PE
110
83
82
72
62
56
54
36
32
32
29
28
28
28
28
28
28
26
25
24
24
21
21
21
21
21
20
18
17
17
8
8
8
8
8
8
8
8
8
8
8
8
8
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
Application
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunoprecipitation (IP)
1598
821
683
663
541
389
272
257
125
91
85
67
55
40
26
21
19
11
10
9
8
4
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
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Catalog No. ABIN1027691
$ 417.45
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN780370 FACS ICC IHC (f) IP Mouse IgG2b Extracellular Domain Log in to see EGFR1 3
1 ABIN6162843 FACS IF IHC (f) CF®640R Mouse IgG2a, kappa Extracellular Domain Log in to see GFR450 0
1 ABIN6162845 FACS IF IHC (f) CF®543 Mouse IgG2a, kappa Extracellular Domain Log in to see GFR450 0
1 ABIN6162859 FACS IF IHC (f) CF®680R Mouse IgG2a, kappa Extracellular Domain Log in to see GFR450 0
1 ABIN6162847 FACS IF IHC (f) CF®647 Mouse IgG2a, kappa Extracellular Domain Log in to see GFR450 0
1 ABIN6162849 FACS IF IHC (f) CF®555 Mouse IgG2a, kappa Extracellular Domain Log in to see GFR450 0
1 ABIN6162853 FACS IF IHC (f) CF®568 Mouse IgG2a, kappa Extracellular Domain Log in to see GFR450 0
1 ABIN6162855 FACS IF IHC (f) CF®770 Mouse IgG2a, kappa Extracellular Domain Log in to see GFR450 0
1 ABIN6162851 FACS IF IHC (f) CF®660R Mouse IgG2a, kappa Extracellular Domain Log in to see GFR450 0
1 ABIN6162861 FACS IF IHC (f) CF®488A Mouse IgG2a, kappa Extracellular Domain Log in to see GFR450 0
1 ABIN6162863 FACS IF IHC (f) CF®594 Mouse IgG2a, kappa Extracellular Domain Log in to see GFR450 0
1 ABIN6162839 FACS IF IHC (f) CF®405S Mouse IgG2a, kappa Extracellular Domain Log in to see GFR450 0
1 ABIN6162841 FACS IF IHC (f) CF405M Mouse IgG2a, kappa Extracellular Domain Log in to see GFR450 0
1 ABIN6162857 FACS IF IHC (f) CF®680 Mouse IgG2a, kappa Extracellular Domain Log in to see GFR450 0
1 ABIN6162874 FACS IF IHC (f) Mouse IgG2a, kappa Extracellular Domain Log in to see GFR450 0
1 ABIN6162765 FACS IF IHC (f) CF405M Mouse IgG2a, kappa Log in to see GFR1195 31G7 0
1 ABIN6162803 FACS IF IHC (f) CF405M Mouse IgG2a, kappa Log in to see GFR1195 0
1 ABIN6162811 FACS IF IHC (f) CF®555 Mouse IgG2a, kappa Log in to see GFR1195 0
1 ABIN6162813 FACS IF IHC (f) CF®660R Mouse IgG2a, kappa Log in to see GFR1195 0
1 ABIN6162819 FACS IF IHC (f) CF®680 Mouse IgG2a, kappa Log in to see GFR1195 0

General

Antigen Epidermal Growth Factor Receptor (EGFR) Antibodies
Epitope Extracellular Domain
(161), (126), (66), (65), (60), (59), (56), (54), (53), (50), (50), (48), (42), (40), (39), (35), (32), (31), (31), (30), (28), (27), (26), (24), (22), (19), (18), (18), (18), (17), (17), (17), (17), (17), (16), (16), (16), (15), (15), (15), (15), (15), (15), (15), (11), (9), (8), (8), (8), (7), (6), (6), (6), (6), (6), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Horse (Equine)
(2658), (911), (742), (27), (25), (18), (17), (14), (11), (7), (2), (2), (2), (1), (1), (1), (1)
Host Mouse
(1545), (1004), (84), (44), (12), (5), (2), (1), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This EGFR antibody is conjugated to PE
(110), (83), (82), (72), (62), (56), (54), (36), (32), (32), (29), (28), (28), (28), (28), (28), (28), (26), (25), (24), (24), (21), (21), (21), (21), (21), (20), (18), (17), (17), (8), (8), (8), (8), (8), (8), (8), (8), (8), (8), (8), (8), (8), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunoprecipitation (IP)
(1598), (821), (683), (663), (541), (389), (272), (257), (125), (91), (85), (67), (55), (40), (26), (21), (19), (11), (10), (9), (8), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 4 references available
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Product Details anti-EGFR Antibody

Target Details EGFR Application Details Handling References for anti-EGFR antibody (ABIN1027691) Images
Specificity The mouse monoclonal antibody EGFR1 reacts with extracellular domain of human protein kinase EGFR (ErbB1 / HER1), epitope within amino acids 6-273.
Cross-Reactivity Mouse (Murine)
No Cross-Reactivity Mouse (Murine)
Characteristics The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
Immunogen Human epidermoid carcinoma line A431
Clone EGFR1
Isotype IgG2b
Plasmids, Primers & others

Target Details EGFR

Product Details anti-EGFR Antibody Application Details Handling References for anti-EGFR antibody (ABIN1027691) Images back to top
Antigen
Alternative Name EGFR (EGFR Antibody Abstract)
Background The oncoprotein EGFR (epidermal growth factor receptor), also known as HER1 / ErbB1, is a member of ErbB family of cell surface receptor tyrosine kinases. This 170 kDa transmembrane glycoprotein is often associated with cancerogenesis, although its activation state is controlled at various levels including trafficking and degradation steps. Binding of receptor-specific ligands to the EGFR ectodomain results in formation of homodimeric or heterodimeric kinase-active complexes into which HER2 / ErbB2 is recruited as a preferred partner. Subsequent signaling cascades such as RAS/MAPK and PI3K/AKT pathways lead to cell proliferation and survival responses.
Pathways NF-kappaB Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation

Application Details

Product Details anti-EGFR Antibody Target Details EGFR Handling References for anti-EGFR antibody (ABIN1027691) Images back to top
Application Notes The reagent is designed for Flow Cytometry analysis of human blood cells using 10 μ,l reagent / 100 μ,l of whole blood or 106 cells in a suspension.The content of a vial (1 ml) is sufficient for 100 tests.
Restrictions For Research Use only

Handling

Product Details anti-EGFR Antibody Target Details EGFR Application Details References for anti-EGFR antibody (ABIN1027691) Images back to top
Reconstitution No reconstitution is necessary.
Buffer The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2 % (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not freeze.
Avoid prolonged exposure to light.
Storage 4 °C
Storage Comment Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.

References for anti-EGFR antibody (ABIN1027691)

Product Details anti-EGFR Antibody Target Details EGFR Application Details Handling Images back to top
Product cited in:

Rebetz, Tian, Persson, Widegren, Salford, Englund, Gisselsson, Fan: "Glial progenitor-like phenotype in low-grade glioma and enhanced CD133-expression and neuronal lineage differentiation potential in high-grade glioma." in: PLoS ONE, Vol. 3, Issue 4, pp. e1936, 2008

Fortunel, Hatzfeld, Rosemary, Ferraris, Monier, Haydont, Longuet, Brethon, Lim, Castiel, Schmidt, Hatzfeld: "Long-term expansion of human functional epidermal precursor cells: promotion of extensive amplification by low TGF-beta1 concentrations." in: Journal of cell science, Vol. 116, Issue Pt 19, pp. 4043-52, 2003

Aigner, Juhl, Malerczyk, Tkybusch, Benz, Czubayko: "Expression of a truncated 100 kDa HER2 splice variant acts as an endogenous inhibitor of tumour cell proliferation." in: Oncogene, Vol. 20, Issue 17, pp. 2101-11, 2001

Akiyama, Smith, Shimizu: "Changing patterns of localization of putative stem cells in developing human hair follicles." in: The Journal of investigative dermatology, Vol. 114, Issue 2, pp. 321-7, 2000